Results 31 to 40 of about 5,115,827 (299)
Respiratory Research, 2021 Background Alpha-1 antitrypsin (AAT) is a major serine protease inhibitor. AAT deficiency (AATD) is a genetic disorder characterized by early-onset severe emphysema.
Katsuyuki Takeda +4 more
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The Different Colors of mAbs in Solution
Antibodies, 2021 The color of a therapeutic monoclonal antibody solution is a critical quality attribute. Consistency of color is typically assessed at time of release and during stability studies against preset criteria for late stage clinical and commercial products. A
Alexandre Ambrogelly
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Arabinosylation of recombinant human immunoglobulin-based protein therapeutics [PDF]
mAbs, 2017 Protein glycosylation is arguably the paramount post-translational modification on recombinant glycoproteins, and highly cited in the literature for affecting the physiochemical properties and the efficacy of recombinant glycoprotein therapeutics. Glycosylation of human immunoglobulins follows a reasonably well-understood metabolic pathway, which gives
Hossler, Patrick +13 more
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Recombinant human preproinsulin expression, purification and reaction with insulin autoantibodies in sera from patients with insulin-dependent diabetes mellitus [PDF]
, 1993 A novel prokaryotic expression vector pGEX-6T was designed for high-level expression of recombinant fusion protein with a histidine-hexapeptide and glutathione-S-transferase at its N-terminus and the recombinant human preproinsulin at its C-terminus ...
Seißler, Jochen +4 more
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Molecular Therapy: Methods & Clinical Development, 2018 Antibodies against recombinant proteins can significantly reduce their effectiveness in unanticipated ways. We evaluated the humoral response of mice with the lysosomal storage disease mucopolysaccharidosis type I treated with weekly intravenous ...
Steven Q. Le +11 more
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Recombinant factorVIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A [PDF]
, 2015 This work was supported by funding from Biogen, including funding for the editorial and writing support in the the development of this ...
Barnes, C +11 more
core +1 more source
Construction of the Recombinant Lentiviral Vector Containing Human GH1 Gene and Its Expression in HEK293T Cells [PDF]
Journal of Cell and Molecular Research, 2016 Human growth hormone (hGH) is a protein with multiple roles in a range of biological functions such as protein, carbohydrates and lipid metabolisms as well as immunity, tissue development and overall growth.
Zahra Roudbari +4 more
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GlycoPEGylation of recombinant therapeutic proteins produced in Escherichia coli [PDF]
Glycobiology, 2006 Covalent attachment of polyethylene glycol, PEGylation, has been shown to prolong the half-life and enhance the pharmacodynamics of therapeutic proteins. Current methods for PEGylation, which rely on chemical conjugation through reactive groups on amino acids, often generate isoforms in which PEG is attached at sites that interfere with bioactivity ...
DeFrees, S. +12 more
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Heterologous expression of a truncated form of human recombinant vascular endothelial growth factor-A and its biological activity in wound healing [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Vascular endothelial growth factor (VEGF) is one of the most effective proteins in angiogenesis, mesenchymal stem cells (MSCs) differentiation and wound healing.
Mohsen Khaki +6 more
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source