Engineered Recombinant Protein Production Systems Originated from Escherichia coli [PDF]
Trends in Peptide and Protein Sciences, 2019 Selection of a suitable host strain is an important step in recombinant production of heterologous proteins. As the prokaryotic systems and especially Escherichia coli (E.
Javad Ranjbari
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Recent Developments of Recombinant Protein Expression for Therapeutic Purposes
Bioscientific Review, 2021 In the past few years, the use of therapeutic recombinant proteins has rapidly expanded in the field of biotechnology. There has been a significant development in the application of the mammalian expression system for recombinant protein production ...
Anam Amir, Aleena Sumrin
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Clinical development of therapeutic recombinant proteins [PDF]
BioTechniques, 2003 Only a small subset of the therapeutics that enter clinical studies will prove to be safe and effective in humans and gain approval for marketing. The success of the products and, by inference, the sponsoring companies can be measured by tracking advancement through the clinical phase and review transitions to marketing approval.
Janice M. Reichert, Cherie Paquette
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Bioluminescent monitoring of recombinant lactic acid bacteria and their products
mBio, 2023 Biotherapeutic strategies to promote health, including the application of engineered microbes to deliver therapeutic molecules, hold strong promise. However, without precision tools to detect therapeutic microbes and their products, we are hampered in ...
In Young Choi +3 more
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Pharmaceuticals, 2021 Correct glycosylation of proteins is essential for production of therapeutic proteins as glycosylation is important for protein solubility, stability, half-life and immunogenicity.
Sacha Zeerleder +9 more
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Therapeutic uses of recombinant complement protein inhibitors [PDF]
Springer Seminars in Immunopathology, 1994 In conclusion, it is apparent that researchers are poised at the threshold of developing inhibitors of complement activation from the molecules in the RCA family. By creating soluble forms of these protective proteins for in vivo administration, or by making transgenic animals expressing these proteins or their derivatives, it may be possible to ...
Kalli, Kimberly R. +2 more
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In situ detection of protein interactions for recombinant therapeutic enzymes [PDF]
Biotechnology and Bioengineering, 2020 Abstract Despite their therapeutic potential, many protein drugs remain inaccessible to patients since they are difficult to secrete. Each recombinant protein has unique physicochemical properties and requires different machinery for proper folding, assembly, and post-translational modifications (PTMs).
Mojtaba Samoudi +10 more
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The Effects of the Recombinant CCR5 T4 Lysozyme Fusion Protein on HIV-1 Infection. [PDF]
PLoS ONE, 2015 Insertion of T4 lysozyme (T4L) into the GPCR successfully enhanced GPCR protein stability and solubilization. However, the biological functions of the recombinant GPCR protein have not been analyzed.We engineered the CCR5-T4L mutant and expressed and ...
Qingwen Jin +10 more
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Expression of recombinant multi-coloured fluorescent antibodies in
, 2011 Background Antibody-fluorophore conjugates are invaluable reagents used in contemporary molecular cell biology for imaging, cell sorting and tracking intracellular events.
Durvasula, Ravi V. +26 more
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Maltose-binding protein enhances secretion of recombinant human granzyme B accompanied by in vivo processing of a precursor MBP fusion protein [PDF]
, 2010 Background: The apoptosis-inducing serine protease granzyme B (GrB) is an important factor contributing to lysis of target cells by cytotoxic lymphocytes.
Wels, Winfried +9 more
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