Results 31 to 40 of about 516,295 (311)

Perspectives for Glyco-Engineering of Recombinant Biopharmaceuticals from Microalgae

Cells, 2020
Microalgae exhibit great potential for recombinant therapeutic protein production, due to lower production costs, immunity to human pathogens, and advanced genetic toolkits.
Lorenzo Barolo, Raffaela M. Abbriano, Audrey S. Commault, Jestin George, Tim Kahlke, Michele Fabris, Matthew P. Padula, Angelo Lopez, Peter J. Ralph, Mathieu Pernice   +9 more
doaj   +1 more source

The Different Colors of mAbs in Solution

Antibodies, 2021
The color of a therapeutic monoclonal antibody solution is a critical quality attribute. Consistency of color is typically assessed at time of release and during stability studies against preset criteria for late stage clinical and commercial products. A
Alexandre Ambrogelly
doaj   +1 more source

Characterization of small molecules inhibiting the pro-angiogenic activity of the zinc finger transcription factor Vezf1 [PDF]

, 2018
Discovery of inhibitors for endothelial-related transcription factors can contribute to the development of anti-angiogenic therapies that treat various diseases, including cancer.
Gowher, Humaira, He, Ming, Norvil, Allison B, Sherris, David, Yang, Qianyi   +4 more
core   +2 more sources

In vivo biodistribution study of TAT-L-Sco2 fusion protein, developed as protein therapeutic for mitochondrial disorders attributed to SCO2 mutations

Molecular Genetics and Metabolism Reports, 2020
The rapid progress achieved in the development of many biopharmaceuticals had a tremendous impact on the therapy of many metabolic/genetic disorders. This type of fruitful approach, called protein replacement therapy (PRT), aimed to either replace the ...
Georgios C. Kaiafas, Dionysia Papagiannopoulou, Αndroulla N. Miliotou, Anastasia S. Tsingotjidou, Parthenopi C. Chalkidou, Aikaterini C. Tsika, Georgios A. Spyroulias, Asterios S. Tsiftsoglou, Lefkothea C. Papadopoulou   +8 more
doaj   +1 more source

Therapeutic benefits of recombinant alpha1-antitrypsin IgG1 Fc-fusion protein in experimental emphysema

Respiratory Research, 2021
Background Alpha-1 antitrypsin (AAT) is a major serine protease inhibitor. AAT deficiency (AATD) is a genetic disorder characterized by early-onset severe emphysema.
Katsuyuki Takeda, Soo-Hyun Kim, Anthony Joetham, Irina Petrache, Erwin W. Gelfand   +4 more
doaj   +1 more source

Semicontinuous Bioreactor Production of Recombinant Butyrylcholinesterase in Transgenic Rice Cell Suspension Cultures. [PDF]

, 2016
An active and tetrameric form of recombinant butyrylcholinesterase (BChE), a large and complex human enzyme, was produced via semicontinuous operation in a transgenic rice cell suspension culture.
Corbin, Jasmine M, Hashimoto, Bryce I, Karuppanan, Kalimuthu, Kyser, Zachary R, McDonald, Karen A, Nandi, Somen, Noe, Amy R, Roberts, Brian A, Rodriguez, Raymond L, Wu, Liying   +9 more
core   +2 more sources

Perinatal Gene Transfer to the Liver [PDF]

, 2011
The liver acts as a host to many functions hence raising the possibility that any one may be compromised by a single gene defect. Inherited or de novo mutations in these genes may result in relatively mild diseases or be so devastating that death within
Buckley, SM, Chan, JK, Howe, SJ, McKay, TR, Rahim, AA, Waddington, SN, Ward, NJ   +6 more
core   +1 more source

Progress in the use of adeno-associated viral vectors for gene therapy [PDF]

, 2004
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Braun-Falco, M., Buning, H., Hallek, M.
core   +1 more source

Preclinical Immunogenicity Testing for Recombinant Therapeutic Proteins

Journal of Immunotoxicology, 2005
The assessment of the immunogenicity of recombinant therapeutic proteins (RTPs) has received more attention in the past 4 years than in the previous 20 years. The induction of clinically adverse events in RTP-treated patients and the subsequent measurement of antibodies to those RTPs has challenged the scientific community to re evaluate the methods ...
Holly W, Smith, Daniel, Wierda
openaire   +2 more sources

Therapy of cancer by insect cells containing recombinant baculovirus encoding genes [PDF]

, 2002
Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions comprising insect cells containing baculovirus that ...
Dhong, Zhongyun, Fidler, Isaiah J., Lu, Weixin   +2 more
core   +1 more source