Results 21 to 30 of about 404,123 (293)

Prospective Use of Brown Spider Venom Toxins as Therapeutic and Biotechnological Inputs

Frontiers in Molecular Biosciences, 2021
Brown spider (genus Loxosceles) venoms are mainly composed of protein toxins used for predation and defense. Bites of these spiders most commonly produce a local dermonecrotic lesion with gravitational spread, edema and hemorrhage, which together are ...
Luiza Helena Gremski, Fernando Hitomi Matsubara, Nayanne Louise Costacurta Polli, Bruno Cesar Antunes, Bruno Cesar Antunes, Pedro Henrique de Caires Schluga, Hanna Câmara da Justa, João Carlos Minozzo, Ana Carolina Martins Wille, Andrea Senff-Ribeiro, Silvio Sanches Veiga   +10 more
doaj   +1 more source

Characterization of a Novel BmαTX47 Toxin Modulating Sodium Channels: The Crucial Role of Expression Vectors in Toxin Pharmacological Activity

Toxins, 2014
Long-chain scorpion toxins with four disulfide bridges exhibit various pharmacological features towards the different voltage-gated sodium channel subtypes. However, the toxin production still remains a huge challenge.
Tian Li, Lingna Xu, Honglian Liu, Yawen He, Songping Liang, Wenxin Li, Yingliang Wu   +6 more
doaj   +1 more source

Insights into brown spider and loxoscelism [PDF]

Invertebrate Survival Journal, 2005
Loxosceles is a genus of cosmopolitan spiders comprising several species, and popularly known as brown spiders or brown recluses. Brown spider bites can cause dermonecrotic lesions and systemic reactions known as loxoscelism.
M H Appel, R Bertoni da Silveira, W Gremski, S S Veiga   +3 more
doaj   +1 more source

Chaperone-mediated native folding of a β-scorpion toxin in the periplasm of E.coli [PDF]

, 2014
Background: Animal neurotoxin peptides are valuable probes for investigating ion channel structure/function relationships and represent lead compounds for novel therapeutics and insecticides.
Cole, Ambrose R., Lampert, A., Wallace, Bonnie A., O'Reilly, A.O., O’Reilly, A.O., Wallace, B.A., Cole, A.R., Lopes, J.L.S.   +7 more
core   +1 more source

Brown Spider (Loxosceles genus) Venom Toxins: Tools for Biological Purposes

Toxins, 2011
Venomous animals use their venoms as tools for defense or predation. These venoms are complex mixtures, mainly enriched of proteic toxins or peptides with several, and different, biological activities.
Andrea Senff-Ribeiro, Silvio Sanches Veiga, Luiza Helena Gremski, Waldemiro Gremski, Rafael Bertoni da Silveira, Oldemir Carlos Mangili, Valéria Pereira Ferrer, Fernando Hitomi Matsubara, Daniele Chaves-Moreira, Ana Carolina M. Wille, Dilza Trevisan-Silva, Olga Meiri Chaim   +11 more
doaj   +1 more source

Cost of Manufacturing for Recombinant Snakebite Antivenoms

Frontiers in Bioengineering and Biotechnology, 2020
Snakebite envenoming is a neglected tropical disease that affects millions of people across the globe. It has been suggested that recombinant antivenoms based on mixtures of human monoclonal antibodies, which target key toxins of medically important ...
Timothy Patrick Jenkins, Andreas Hougaard Laustsen   +1 more
doaj   +1 more source

Retrograde transport pathways utilised by viruses and protein toxins [PDF]

, 2006
A model has been presented for retrograde transport of certain toxins and viruses from the cell surface to the ER that suggests an obligatory interaction with a glycolipid receptor at the cell surface. Here we review studies on the ER trafficking cholera
J Michael Lord, Lord, Mike, Spooner, Robert A., Smith, Daniel C., Daniel C Smith, Roberts, L. M. (Lynne M.), Andrew J Easton, Easton, A. J. (Andrew J.), Robert A Spooner, Lynne M Roberts   +9 more
core   +1 more source

Towards a Recombinant Vaccine against Diphtheria Toxin [PDF]

Infection and Immunity, 1998
ABSTRACT Two recombinant fragments of diphtheria toxin (DT) were fused to an engineered tandem repeat of the immunoglobulin (Ig) binding domain of protein A, called ZZ. These fragments are (i) the receptor binding domain (DTR), which comprises amino acids 382 to 535 of DT, and (ii) a linear peptide (DT 168–220
K, Lobeck, P, Drevet, M, Léonetti, C, Fromen-Romano, F, Ducancel, E, Lajeunesse, C, Lemaire, A, Ménez   +7 more
openaire   +2 more sources

A Novel Insecticidal Spider Peptide that Affects the Mammalian Voltage-Gated Ion Channel hKv1.5

Frontiers in Pharmacology, 2021
Spider venoms include various peptide toxins that modify the ion currents, mainly of excitable insect cells. Consequently, scientific research on spider venoms has revealed a broad range of peptide toxins with different pharmacological properties, even ...
Diana Alvarado, Samuel Cardoso-Arenas, Ligia-Luz Corrales-García, Ligia-Luz Corrales-García, Herlinda Clement, Iván Arenas, Pavel Andrei Montero-Dominguez, Timoteo Olamendi-Portugal, Fernando Zamudio, Agota Csoti, Jesús Borrego, Gyorgy Panyi, Ferenc Papp, Gerardo Corzo   +13 more
doaj   +1 more source

Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium

BMC Microbiology, 2008
Background Major Clostridium difficile virulence factors are the exotoxins TcdA and TcdB. Due to the large size and poor stability of the proteins, the active recombinant TcdA and TcdB have been difficult to produce. Results The toxin genes tcdA and tcdB
Nie Weijia, Sun Xingmin, He Xiangyun, Wang Jufang, Zhou Boping, Yang Guilin, Tzipori Saul, Feng Hanping   +7 more
doaj   +1 more source