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Frontiers in Bioengineering and Biotechnology, 2022 Recombinant therapeutic proteins (RTPs) are important parts of biopharmaceuticals. Chinese hamster ovary cells (CHO) have become the main cell hosts for the production of most RTPs approved for marketing because of their high-density suspension growth ...
Zheng-Mei Li +7 more
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Advances in Molecular Function and Recombinant Expression of Human Collagen. [PDF]
Pharmaceuticals (Basel)Collagen is the main protein found in skin, bone, cartilage, ligaments, tendons and connective tissue, and it can exhibit properties ranging from compliant to rigid or form gradients between these states.
Sun W, Shahrajabian MH, Ma K, Wang S.
europepmc +2 more sources
Recombinant protein expression in Escherichia coli: advances and challenges
Frontiers in Microbiology, 2014 Escherichia coli is one of the organisms of choice for the production of recombinant proteins. Its use as a cell factory is well-established and it has become the most popular expression platform.
German L Rosano +2 more
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Metabolic EngineeringThe production of recombinant proteins in a host using synthetic constructs such as plasmids comes at the cost of detrimental effects such as reduced growth, energetic inefficiencies, and other stress responses, collectively known as metabolic stress ...
Omid Oftadeh, Vassily Hatzimanikatis
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Recombinant Expression and Characterization of α-Conotoxin LvIA in Escherichia coli
Marine Drugs, 2016 α-Conotoxin LvIA is derived from Conus lividus, native to Hainan, and is the most selective inhibitor of α3β2 nicotinic acetylcholine receptors (nAChRs) known to date.
Xiaopeng Zhu +6 more
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Polyionic Tags as Enhancers of Protein Solubility in Recombinant Protein Expression
Microorganisms, 2018 Since the introduction of recombinant protein expression in the second half of the 1970s, the growth of the biopharmaceutical field has been rapid and protein therapeutics has come to the foreground.
Vasiliki Paraskevopoulou +1 more
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Open Biology, 2016 The ease of genetic manipulation, low cost, rapid growth and number of previous studies have made Escherichia coli one of the most widely used microorganism species for producing recombinant proteins.
Baolei Jia, Che Ok Jeon
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Molecular engineering of insulin for recombinant expression in yeast.
Trends in Biotechnology, 2023 Since the first administration of insulin to a person with diabetes in 1922, scientific contributions from academia and industry have improved insulin therapy and access.
Thomas B. Kjeldsen +6 more
semanticscholar +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 In recent years, mammalian cells have become the primary host cells for the production of recombinant therapeutic proteins (RTPs). Despite that the expression of RTPs in mammalian cells can be improved by directly optimizing or engineering the expression
Mian Wei +4 more
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Frontiers in Bioengineering and Biotechnology, 2022 Chinese hamster ovary (CHO) cells are currently the most widely used host cells for recombinant therapeutic protein (RTP) production. Currently, the RTP yields need to increase further to meet the market needs and reduce costs.
Qin Li +8 more
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