Results 21 to 30 of about 356,092 (265)

A recombinant rabies virus encoding two copies of the glycoprotein gene confers protection in dogs against a virulent challenge. [PDF]

PLoS ONE, 2014
The rabies virus (RABV) glycoprotein (G) is the principal antigen responsible for the induction of virus neutralizing antibodies (VNA) and is the major modality of protective immunity in animals.
Xiaohui Liu, Youtian Yang, Zhaojin Sun, Jing Chen, Jun Ai, Can Dun, Zhen F Fu, Xuefeng Niu, Xiaofeng Guo   +8 more
doaj   +1 more source

Development of an Adeno-Associated Virus-Vectored SARS-CoV-2 Vaccine and Its Immunogenicity in Mice

Frontiers in Cellular and Infection Microbiology, 2022
Owing to the outbreak of the novel coronavirus (SARS-CoV-2) worldwide at the end of 2019, the development of a SARS-CoV-2 vaccine became an urgent need.
Xi Qin, Shanhu Li, Xiang Li, Dening Pei, Yu Liu, Youxue Ding, Lan Liu, Hua Bi, Xinchang Shi, Ying Guo, Enyue Fang, Fang Huang, Lei Yu, Liuqiang Zhu, Yifang An, C. Alexander Valencia, Yuhua Li, Biao Dong, Yong Zhou   +18 more
doaj   +1 more source

Construction and characterization of a contagious ecthyma virus double-gene deletion strain and evaluation of its potential as a live-attenuated vaccine in goat

Frontiers in Immunology, 2022
Contagious ecthyma is a highly contagious viral disease with zoonotic significance caused by orf virus (ORFV) that affects domestic, ruminants and humans.
Zhen Zhu, Guanggang Qu, Jige Du, Changjiang Wang, Yong Chen, Zhanning Shen, Zhiyu Zhou, Chunsheng Yin, Xiaoyun Chen   +8 more
doaj   +1 more source

Naturally occurring genotype 2b/1a hepatitis C virus in the United States

Virology Journal, 2011
Background Hepatitis C Virus (HCV) infected patients are frequently repeatedly exposed to the virus, but very few recombinants between two genotypes have been reported.
Striker Rob, Ansari Israr H, Accola Molly A, Bhattacharya Dipankar, Rehrauer William M   +4 more
doaj   +1 more source

Recombinant vaccines against bluetongue virus

Virus Research, 2014
Bluetongue (BT) is a hemorrhagic disease of ruminants caused by bluetongue virus (BTV), the prototype member of the genus Orbivirus within the family Reoviridae and is transmitted via biting midges of the genus Culicoides. BTV can be found on all continents except Antarctica, and up to 26 immunologically distinct BTV serotypes have been identified ...
Calvo-Pinilla, Eva, Castillo-Olivares, Javier, Jabbar, Tamara, Ortego, Javier, de la Poza, Francisco, Marín-López, Alejandro   +5 more
openaire   +2 more sources

SAFETY AND IMMUNOGENICITY OF COLD-ADAPTED RECOMBINANT INFLUENZA VECTOR EXPRESSING ESAT-6 AND AG85А ANTIGENS OF M. TUBERCULOSIS

Вопросы вирусологии, 2017
Recombinant viral vectors represent one of the most promising platforms for creating a new generation of vaccines against tuberculosis. We constructed a vaccine candidate based on a cold-adapted influenza vector with a truncated NS1 protein containing an
M. V. Sergeeva, A. A. Pulkina, K. A. Vasiliev, E. A. Romanovskaya-Romanko, A. B. Komissarov, O. A. Kuchur, A. Yu. Egorov, L. M. Tsybalova, M. A. Stukova   +8 more
doaj   +1 more source

Construction and Rescue of a Rabies Virus with Duplicated Glycoprotein Gene

Vaccine Research, 2021
Introduction: Rabies is almost always fatal but entirely preventable through proper vaccination. Inadequacy of costly high-quality cell culture vaccines is sometimes a bottleneck for expanded rabies control plans.
Ashkan Alamdary , Alireza Gholami, Mohammad Azizi, Zahra Noormohammadi   +3 more
doaj   +1 more source

Construction of three strains of recombinant oncolytic vaccinia virus and their anti-tumor activity [PDF]

Jichu yixue yu linchuang, 2020
Objective The aim of this study is to construct a recombinant oncolytic vaccinia virus with CCL5 and SSTR2 genes and to detect its antitumor activity. Methods Recombinant vaccinia virus eukaryotic expression plasmid pSC65-CCL5-SSTR2-Luc+ was constructed.
LI Dan-yang, FANG Jing-jing, TANG Hui
doaj  

A new Defective Helper RNA to produce recombinant Sindbis virus that infects neurons but does not propagate

Frontiers in Neuroanatomy, 2016
Recombinant Sindbis viruses are important tools in neuroscience because they combine rapid and high transgene expression with a capacity to carry large transgenes.
Justus M Kebschull, Justus M Kebschull, Pedro eGarcia da Silva, Anthony M Zador   +3 more
doaj   +1 more source

Immunogenic and Protective Properties of Recombinant Hemagglutinin of Influenza A (H5N8) Virus

Vaccines
In this study, we characterized recombinant hemagglutinin (HA) of influenza A (H5N8) virus produced in Chinese hamster ovary cells (CHO-K1s). Immunochemical analysis showed that the recombinant hemagglutinin was recognized by the serum of ferrets ...
Nadezhda B. Rudometova, Anastasia A. Fando, Lyubov A. Kisakova, Denis N. Kisakov, Mariya B. Borgoyakova, Victoria R. Litvinova, Vladimir A. Yakovlev, Elena V. Tigeeva, Danil I. Vahitov, Sergey V. Sharabrin, Dmitriy N. Shcherbakov, Veronika I. Evseenko, Ksenia I. Ivanova, Andrei S. Gudymo, Tatiana N. Ilyicheva, Vasiliy Yu. Marchenko, Alexander A. Ilyichev, Andrey P. Rudometov, Larisa I. Karpenko   +18 more
doaj   +1 more source