Results 221 to 230 of about 12,788 (278)

Creation and manipulation of bipartite expression transgenes in C. elegans using phiC31 recombinase. [PDF]

Genetics
Nonet ML.
europepmc   +1 more source

Allele‐Specific GNAQ Q209 Mutations Reveal Context‐Dependent Oncogenic Programs in Uveal Melanoma

Pigment Cell &Melanoma Research, Volume 39, Issue 6, November 2026.
Using matched immune‐competent, multistep uveal melanoma models, we show that GNAQ Q209L and Q209R mutations are not functionally equivalent. Q209L drives faster in vivo progression but reduces in vitro proliferation and migration, whereas Q209R promotes greater in vitro fitness and preferential FAK‐YAP activation, revealing an allele‐dependent ...
Vinesh Jarajapu, Sathya Neelature Sriramareddy, Nicol Mecozzi, Kaizhen Wang, Florian A. Karreth, Xiaonan Xu   +5 more
wiley   +1 more source

Adsorption of phage T2 is inhibited due to inversion of cryptic prophage DNA by the serine recombinase PinQ. [PDF]

Nucleic Acids Res
Kirigo J, Huelgas-Méndez D, Tomás M, Benedik MJ, García-Contreras R, Wood TK.   +5 more
europepmc   +1 more source

Endothelial Exostosin‐1 Is Needed for Glycocalyx Integrity and Inflammatory Resolution in Acute Lung Injury

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Endothelial Ext1 is essential for maintaining heparan sulfate–rich endothelial glycocalyx integrity. Loss of Ext1 reduces glycocalyx thickness, resulting in enhanced leukocyte adhesion, increased vascular permeability, and exaggerated inflammatory responses following lipopolysaccharide (LPS) challenge.
Yuki Kawasaki, Hiroyuki Tomita, Kodai Suzuki, Chihiro Takada, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Hirotsugu Fukuda, Toru Minamiyama, Genki Yoshimura, Ryo Kamidani, Yoshinori Kakino, Tomotaka Miura, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Akio Suzuki, Kazu Matsumoto, Nobuyuki Tetsuka, Shozo Yoshida, Yoichi Maekawa, Yu Yamaguchi, Hideshi Okada   +22 more
wiley   +1 more source

Eukaryotic Recombinases Duplicated After Divergence From Known Asgard Archaeal RadA: Implications for the Evolution of Sex During Eukaryogenesis. [PDF]

Genome Biol Evol
Matsuo L, Novák Vanclová AMG, Pomiankowski A, Lane N, Dacks JB.   +4 more
europepmc   +1 more source

Ten‐Eleven Translocation Enzymes Control the Rate and Mode of Retinal Progenitor Cell Division in the Developing Retina

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Early RPCs divide predominantly symmetrically and exhibit a high proliferation rate, resulting in rapid retinal growth. Late RPCs divide predominantly asymmetrically and exhibit a low proliferation rate. Our results suggest that TET‐deficient RPCs divide predominantly asymmetrically but exhibit a high proliferation rate.
Galina Dvoriantchikova, Michelle Fleishaker, Byron L. Lam, Dmitry Ivanov   +3 more
wiley   +1 more source

Systematic evaluation of the DNA repair machinery facilitated the development of efficient genome editing tools for the red yeast <i>Rhodotorula toruloides</i>. [PDF]

Synth Syst Biotechnol
Chen Q, Lyu L, Wang S, Zhao ZK.
europepmc   +1 more source

Engineering Conditional Transgene Expression in Nicotiana benthamiana. [PDF]

Plant Biotechnol J
Garcia-Perez E, Vazquez-Vilar M, Orzaez D.   +2 more
europepmc   +1 more source

Characterization of recombinase activity across cellular growth phases. [PDF]

Sci Rep
Gonzalez-Colell M, Macia J.
europepmc   +1 more source

Advances in multiplex precision genome editing in eukaryotic and prokaryotic systems. [PDF]

Curr Opin Biotechnol
Golla DA, Sun C, Haugh L, Straub N, Gao X.   +4 more
europepmc   +1 more source