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Phage Recombinases and Their Applications
2012The homologous recombination systems of linear double-stranded (ds)DNA bacteriophages are required for the generation of genetic diversity, the repair of dsDNA breaks, and the formation of concatemeric chromosomes, the immediate precursor to packaging.
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Strand Selection by the Tyrosine Recombinases
2005Publisher Summary This chapter focuses on four tyrosine recombinases for which there is a wealth of biochemical and structural data. This chapter reviews the biochemical and structural findings for each of these enzymes. This chapter also examines the factors that influence strand selection and consider the possible function of strand selection in ...
Linda, Lee, Paul D, Sadowski
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Safety Assessment of Cre Recombinase
Journal of Agricultural and Food Chemistry, 2006Cre recombinase, when used as a tool in agricultural biotechnology, can precisely excise DNA sequences that may be useful in the introduction of a new trait but are not needed in the commercial product. Although the cre genetic material would not be present in the final product, the present studies were performed to assess the safety of Cre recombinase
Ronald E, Hileman +4 more
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Genome Engineering with Custom Recombinases
2014Site-specific recombinases are valuable tools for myriad basic research and genome engineering applications. In particular, hybrid recombinases consisting of catalytic domains from the resolvase/invertase family of serine recombinases fused to Cys2-His2 zinc-finger or TAL effector DNA-binding domains are capable of introducing targeted modifications ...
Thomas, Gaj, Carlos F, Barbas
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Regulation and Evolution of the RAG Recombinase
2015The modular, noncontiguous architecture of the antigen receptor genes necessitates their assembly through V(D)J recombination. This program of DNA breakage and rejoining occurs during early lymphocyte development, and depends on the RAG1 and RAG2 proteins, whose collaborative endonuclease activity targets specific DNA motifs enriched in the antigen ...
Grace, Teng, David G, Schatz
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Harnessing orthogonal recombinases to decipher cell fate with enhanced precision
Trends in Cell Biology, 2022Bin Zhou, Kathy O Lui, Xiuxiu Liu
exaly
Topoisomerases and site-specific recombinases: similarities in structure and mechanism
Critical Reviews in Biochemistry and Molecular Biology, 2010Wei Yang
exaly
Oligonucleotide recombination in corynebacteria without the expression of exogenous recombinases
Journal of Microbiological Methods, 2014Alexander A Krylov, Sergey V Mashko
exaly
Dre recombinase and recombinase systems employing Dre recombinase
2008SAUER BRIAN L, MCDERMOTT JEFFREY
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