Sequence analysis of tyrosine recombinases allows annotation of mobile genetic elements in prokaryotic genomes [PDF]
Molecular Systems Biology, 2021 Mobile genetic elements (MGEs) sequester and mobilize antibiotic resistance genes across bacterial genomes. Efficient and reliable identification of such elements is necessary to follow resistance spreading.
Orsolya Barabas +2 more
exaly +5 more sources
Genome engineering in Bacillus anthracis using tyrosine site-specific recombinases [PDF]
PLoS ONE, 2017 Tyrosine site-specific recombinases (T-SSR) are polynucleotidyltransferases that catalyze cutting and joining reactions between short specific DNA sequences. We developed three systems for performing genetic modifications in Bacillus anthracis that use T-
Stephen H. Leppla +2 more
exaly +6 more sources
Archaeal tyrosine recombinases. [PDF]
FEMS Microbiology Reviews, 2021 International audienceABSTRACT The integration of mobile genetic elements into their host chromosome influences the immediate fate of cellular organisms and gradually shapes their evolution.
Catherine Badel +2 more
exaly +5 more sources
Minimal mutational requirements for conversion of a telomere resolvase into a Cre-like site-specific recombinase. [PDF]
PLoS ONEHairpin telomere resolvases comprise a family of enzymes that produce the hairpin (hp) telomeres of bacteria and their phages that possess linear chromosomes and plasmids terminated by covalently closed hp telomeres.
Shu Hui Huang, Kerri Kobryn
doaj +2 more sources
Conversion of a telomere resolvase into a Cre-like site-specific recombinase. [PDF]
PLoS ONEHairpin telomere resolvases are a unique family of enzymes involved in producing the hairpin (hp) telomeres of bacterial organisms and phages that possess linear DNA's terminated by hp telomeres.
Shu Hui Huang +2 more
doaj +2 more sources
G lomhopper—a subfamily of DUF3504-encoding CryptonA elements in Glomeromycota [PDF]
Mobile DNABackground Transposable elements drive genomic changes and are mobilized by specific nucleases. Among them are tyrosine recombinases (YRs), which mediate DNA cleavage and rejoining. YR-encoding elements, such as DIRS, Ngaro, Crypton, and Starships, occur
Marianna Krysińska +2 more
doaj +2 more sources
Identification of the Integration/Excision Module and Regulatory Elements Involved in the Mobility of IME8, an Integrative and Mobilizable Element From Mosquitocidal Lysinibacillus sphaericus [PDF]
Microbial BiotechnologyLysinibacillus sphaericus, a bacterium successfully used in the control of mosquitoes, bears its insecticidal traits in GI8, a recently identified mosquitocidal genomic island.
Yifeng Hu +5 more
doaj +2 more sources
Interaction of the putative tyrosine recombinases RipX (UU145), XerC (UU222), and CodV (UU529) of Ureaplasma parvum serovar 3 with specific DNA. [PDF]
FEMS Microbiology Letters, 2013 Joachim Spergser +2 more
exaly +2 more sources
Engineering Biology, 2020 Inducible genetic switches based on tyrosine recombinase-based DNA excision are a promising platform for the regulation and control of chimeric antigen receptor (CAR) T cell activity in cancer immunotherapy. These switches exploit the increased stability
Jack E. Bowyer +3 more
doaj +1 more source
BMC Genomics, 2022 Background Bacteriophages are widely considered to be highly abundant and genetically diverse, with their role in the evolution and virulence of many pathogens becoming increasingly clear.
Steven Batinovic +5 more
doaj +1 more source