Discovery and characterization of novel Cre-type tyrosine site-specific recombinases for advanced genome engineering [PDF]
Nucleic Acids Research, 2023 Tyrosine-type site-specific recombinases (Y-SSRs) are versatile tools for genome engineering due to their ability to mediate excision, integration, inversion and exchange of genomic DNA with single nucleotide precision.
Buchholz, Frank +7 more
core +4 more sources
In vitro DNA Inversions Mediated by the PsrA Site-Specific Tyrosine Recombinase of Streptococcus pneumoniae [PDF]
Frontiers in Molecular Biosciences, 2020 Site-specific recombination is a DNA breaking and reconstructing process that plays important roles in various cellular pathways for both prokaryotes and eukaryotes. This process requires a site-specific recombinase and direct or inverted repeats.
Jingwen Li +5 more
doaj +4 more sources
Prediction of designer-recombinases for DNA editing with generative deep learning [PDF]
, 2022 Site-specific tyrosine-type recombinases are effective tools for genome engineering, with the first engineered variants having demonstrated therapeutic potential.
Buchholz, Frank +3 more
core +10 more sources
Towards a more accurate annotation of tyrosine-based site-specific recombinases in bacterial genomes [PDF]
Mobile DNA, 2012 Background Tyrosine-based site-specific recombinases (TBSSRs) are DNA breaking-rejoining enzymes. In bacterial genomes, they play a major role in the comings and goings of mobile genetic elements (MGEs), such as temperate phage genomes, integrated ...
Van Houdt Rob +4 more
doaj +4 more sources
In vivo and in vitro characterization and application of tyrosine recombinases for metabolic engineering [PDF]
, 2018 Site-specific recombinases are a family of DNA-modifying enzymes that can recognize short specific DNA sequences and drive recombination between them to rearrange DNA fragments which results in excision, integration or inversion.
Liu, Wei
core +5 more sources
Starships are active eukaryotic transposable elements mobilized by a new family of tyrosine recombinases. [PDF]
Proc Natl Acad Sci U S A, 2023 Transposable elements in eukaryotic organisms have historically been considered “selfish,” at best conferring indirect benefits to their host organisms. The Starships are a recently discovered feature in fungal genomes that are, in some cases, predicted to confer beneficial traits to their ...
Urquhart AS +3 more
europepmc +5 more sources
Discovery and evolution of novel Cre-type tyrosine site-specific recombinases for advanced genome engineering [PDF]
, 2023 Tyrosine site-specific recombinases (Y-SSRs) are DNA editing enzymes that play a valuable role for the manipulation of genomes, due to their precision and versatility.
Jelicic, Milica
core +5 more sources
c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis
Hepatology, EarlyView., 2022 In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie +17 more
wiley +1 more source
A New Group of Tyrosine Recombinase-Encoding Retrotransposons [PDF]
Molecular Biology and Evolution, 2004 A wide variety of novel tyrosine recombinase (YR)-encoding retrotransposons were identified using data emerging from the various eukaryotic genome sequencing projects. Although many of these elements are clearly members of the previously described DIRS group of YR retrotransposons, a substantial number, including elements from a variety of fungi and ...
Timothy J D, Goodwin +1 more
openaire +2 more sources
The Evolution of Tyrosine-Recombinase Elements in Nematoda
PLoS ONE, 2014 18 ...
Szitenberg, Amir +3 more
openaire +7 more sources