Results 1 to 10 of about 18,459 (107)

The carboxy-terminal αN helix of the archaeal XerA tyrosine recombinase is a molecular switch to control site-specific recombination. [PDF]

PLoS One, 2013
Tyrosine recombinases are conserved in the three kingdoms of life. Here we present the first crystal structure of a full-length archaeal tyrosine recombinase, XerA from Pyrococcus abyssi, at 3.0 Å resolution.
Serre MC, El Arnaout T, Brooks MA, Durand D, Lisboa J, Lazar N, Raynal B, van Tilbeurgh H, Quevillon-Cheruel S.   +8 more
europepmc   +4 more sources

In vitro DNA Inversions Mediated by the PsrA Site-Specific Tyrosine Recombinase of Streptococcus pneumoniae. [PDF]

Front Mol Biosci, 2020
Site-specific recombination is a DNA breaking and reconstructing process that plays important roles in various cellular pathways for both prokaryotes and eukaryotes. This process requires a site-specific recombinase and direct or inverted repeats.
Li J, Wang J, Ruiz-Cruz S, Espinosa M, Zhang JR, Bravo A.   +5 more
europepmc   +2 more sources

The evolution of tyrosine-recombinase elements in Nematoda. [PDF]

PLoS One, 2014
Transposable elements can be categorised into DNA and RNA elements based on their mechanism of transposition. Tyrosine recombinase elements (YREs) are relatively rare and poorly understood, despite sharing characteristics with both DNA and RNA elements ...
Szitenberg A, Koutsovoulos G, Blaxter ML, Lunt DH.   +3 more
europepmc   +2 more sources

Study of VIPER and TATE in kinetoplastids and the evolution of tyrosine recombinase retrotransposons. [PDF]

Mob DNA, 2019
Background Kinetoplastids are a flagellated group of protists, including some parasites, such as Trypanosoma and Leishmania species, that can cause diseases in humans and other animals.
Ribeiro YC, Robe LJ, Veluza DS, Dos Santos CMB, Lopes ALK, Krieger MA, Ludwig A.   +6 more
europepmc   +2 more sources

Deoxyuridine triphosphates modified with tyrosine aromatic groups for direct electrochemical detection of double-stranded DNA products of isothermal recombinase polymerase amplification

Electrochemistry Communications, 2021
A set of novel 2′-deoxyuridine-5′-triphosphate (dUTP) derivatives modified with tyrosine (Tyr) or tryptophan (Trp) aromatic groups (m-dUTP) was tested as bearers of electroactive ‘labels’ for double-stranded DNA (dsDNA) detection as well as proper ...
Alexander V Chudinov, Svetlana Khmeleva, Sergey P Radko   +2 more
exaly   +3 more sources

Glomhopper-a subfamily of DUF3504-encoding CryptonA elements in Glomeromycota. [PDF]

Mob DNA
Background Transposable elements drive genomic changes and are mobilized by specific nucleases. Among them are tyrosine recombinases (YRs), which mediate DNA cleavage and rejoining. YR-encoding elements, such as DIRS, Ngaro, Crypton, and Starships, occur
Krysińska M, Barua D, Muszewska A.
europepmc   +2 more sources

Minimal mutational requirements for conversion of a telomere resolvase into a Cre-like site-specific recombinase. [PDF]

PLoS One
Hairpin telomere resolvases comprise a family of enzymes that produce the hairpin (hp) telomeres of bacteria and their phages that possess linear chromosomes and plasmids terminated by covalently closed hp telomeres.
Huang SH, Kobryn K.
europepmc   +2 more sources

Candidate Genomic Features Associated with Persistence in <i>Enterococcus</i> spp. [PDF]

Microorganisms
Bacterial persistence has been extensively studied as a possible explanation for strain survival under stress; however, in Enterococcus spp., this ability is still an understudied phenomenon. In this study, 40 Enterococcus spp. isolates of human clinical
Geraldes C, Silva C, Vale F, Cunha E, Araújo C, Nunes M, Dias R, Tavares L, Guerreiro JF, Oliveira M.   +9 more
europepmc   +2 more sources

Conversion of a telomere resolvase into a Cre-like site-specific recombinase. [PDF]

PLoS One
Hairpin telomere resolvases are a unique family of enzymes involved in producing the hairpin (hp) telomeres of bacterial organisms and phages that possess linear DNA's terminated by hp telomeres.
Huang SH, Balouchi M, Kobryn K.
europepmc   +2 more sources

Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit

Engineering Biology, 2020
Inducible genetic switches based on tyrosine recombinase-based DNA excision are a promising platform for the regulation and control of chimeric antigen receptor (CAR) T cell activity in cancer immunotherapy. These switches exploit the increased stability
Jack E. Bowyer, Deboki Chakravarti, Wilson W. Wong, Declan G. Bates   +3 more
doaj   +1 more source