Results 31 to 40 of about 205,532 (202)
Zinc finger recombinases with adaptable DNA sequence specificity [PDF]
, 2011 Site-specific recombinases have become essential tools in genetics and molecular biology for the precise excision or integration of DNA sequences. However, their utility is currently limited to circumstances where the sites recognized by the recombinase ...
Proudfoot, C. +19 more
core +1 more source
Mobile DNA, 2011 Background "Domestication" of transposable elements (TEs) led to evolutionary breakthroughs such as the origin of telomerase and the vertebrate adaptive immune system.
Kojima Kenji K, Jurka Jerzy
doaj +1 more source
The integrase family of tyrosine recombinases: evolution of a conserved active site domain [PDF]
Nucleic Acids Research, 1997 The integrases are a diverse family of tyrosine recombinases which rearrange DNA duplexes by means of conservative site-specific recombination reactions. Members of this family, of which the well-studied lambda Int protein is the prototype, were previously found to share four strongly conserved residues, including an active site tyrosine directly ...
D, Esposito, J J, Scocca
openaire +2 more sources
Molecular Oncology, 2022 ERK3, officially known as mitogen‐activated protein kinase 6 (MAPK6), is a poorly studied mitogen‐activated protein kinase (MAPK). Recent studies have revealed the upregulation of ERK3 expression in cancer and suggest an important role for ERK3 in ...
Sreeram Vallabhaneni +5 more
doaj +1 more source
Mobile Element Integration Reveals a Chromosome Dimer Resolution System in Legionellales
mBio, 2022 In bacteria, the mechanisms used to repair DNA lesions during genome replication include homologous recombination between sister chromosomes. This can lead to the formation of chromosome dimers if an odd number of crossover events occurs. The dimers must
Beth Nicholson +2 more
doaj +1 more source
Mechanistic Insights Into Filamentous Phage Integration In Vibrio cholerae
Frontiers in Microbiology, 2014 Vibrio cholerae, the etiological agent of acute diarrhoeal disease cholera, harbors large numbers of lysogenic filamentous phages, contribute significantly to the host pathogenesis and provide fitness factors to the pathogen that help the bacterium to ...
Bhabatosh eDas
doaj +1 more source
The dif/Xer recombination systems in proteobacteria. [PDF]
PLoS ONE, 2009 In E. coli, 10 to 15% of growing bacteria produce dimeric chromosomes during DNA replication. These dimers are resolved by XerC and XerD, two tyrosine recombinases that target the 28-nucleotide motif (dif) associated with the chromosome's replication ...
Christophe Carnoy, Claude-Alain Roten
doaj +1 more source
SOS-Independent Pyocin Production in P. aeruginosa Is Induced by XerC Recombinase Deficiency
mBio, 2021 Pyocins are phage tail-like protein complexes that can be used by Pseudomonas aeruginosa to enact intraspecies competition by killing competing strains. The pyocin gene cluster also encodes holin and lysin enzymes that lyse producer cells to release the ...
Nina S. Baggett +2 more
doaj +1 more source
Proceedings of the National Academy of Sciences, 2022 Transposable elements in eukaryotic organisms have historically been considered “selfish,” at best conferring indirect benefits to their host organisms. The Starships are a recently discovered feature in fungal genomes that are, in some cases, predicted to confer beneficial traits to their ...
Andrew S. Urquhart +3 more
openaire +4 more sources
Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors [PDF]
, 2004 BACKGROUND: Inactivating genes in vivo is an important technique for establishing their function in the adult nervous system. Unfortunately, conventional knockout mice may suffer from several limitations including embryonic or perinatal lethality and the
Hermens, Wim T J M C +39 more
core +1 more source