Results 11 to 20 of about 205,532 (202)

Resolution of Mismatched Overlap Holliday Junction Intermediates by the Tyrosine Recombinase IntDOT. [PDF]

J Bacteriol, 2017
CTnDOT is an integrated conjugative element found in Bacteroides species. CTnDOT contains and transfers antibiotic resistance genes.
Ringwald K, Yoneji S, Gardner J.
europepmc   +5 more sources

Genome engineering in Bacillus anthracis using tyrosine site-specific recombinases. [PDF]

PLoS ONE, 2017
Tyrosine site-specific recombinases (T-SSR) are polynucleotidyltransferases that catalyze cutting and joining reactions between short specific DNA sequences. We developed three systems for performing genetic modifications in Bacillus anthracis that use T-
Andrei P Pomerantsev, Rita M McCall, Margaret Chahoud, Nathan K Hepler, Rasem Fattah, Stephen H Leppla   +5 more
doaj   +4 more sources

Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus

genesis, 2004
Catecholaminergic neurons are affected in several neurological and psychiatric diseases. Tyrosine hydroxylase (TH) is the first, rate-limiting enzyme in catecholamine synthesis.
Bengtsson, Henrik,, Kylberg, Annika,, Gustafsson, Anna,, Lindeberg, Jonas,, Söderström, Stine,, Usoskin, Dmitry,, Ebendal, Ted,   +6 more
core   +3 more sources

Control of directionality in the DNA strand-exchange reaction catalysed by the tyrosine recombinase TnpI. [PDF]

Nucleic Acids Res, 2010
In DNA site-specific recombination catalysed by tyrosine recombinases, two pairs of DNA strands are sequentially exchanged between separate duplexes and the mechanisms that confer directionality to this theoretically reversible reaction remain unclear ...
Vanhooff V, Normand C, Galloy C, Segall AM, Hallet B.   +4 more
europepmc   +5 more sources

Sequence analysis of tyrosine recombinases allows annotation of mobile genetic elements in prokaryotic genomes

Molecular Systems Biology, 2021
Mobile genetic elements (MGEs) sequester and mobilize antibiotic resistance genes across bacterial genomes. Efficient and reliable identification of such elements is necessary to follow resistance spreading.
Georgy Smyshlyaev, Alex Bateman, Orsolya Barabas   +2 more
doaj   +3 more sources

Self-control in DNA site-specific recombination mediated by the tyrosine recombinase TnpI.

Molecular Microbiology, 2006
Tn4430 is a distinctive transposon of the Tn3 family that encodes a tyrosine recombinase (TnpI) to resolve replicative transposition intermediates. The internal resolution site of Tn4430 (IRS, 116 bp) contains two inverted repeats (IR1 and IR2) at the ...
Didier Lereclus, Lereclus, Didier, Galloy, Christine, Bernard Révet, Vanhooff, Virginie, Révet, Bernard, Bernard Hallet, Agaisse, Hervé, Christine Galloy, Hallet, Bernard, Virginie Vanhooff, Hervé Agaisse   +11 more
core   +3 more sources

Archaeal tyrosine recombinases

FEMS Microbiology Reviews, 2021
ABSTRACTThe integration of mobile genetic elements into their host chromosome influences the immediate fate of cellular organisms and gradually shapes their evolution. Site-specific recombinases catalyzing this integration have been extensively characterized both in bacteria and eukarya.
Badel, Catherine, da Cunha, Violette, Oberto, J.   +2 more
openaire   +2 more sources

Challenging a paradigm: the role of DNA homology in tyrosine recombinase reactions. [PDF]

Microbiol Mol Biol Rev, 2009
SUMMARYA classical feature of the tyrosine recombinase family of proteins catalyzing site-specific recombination, as exemplified by the phage lambda integrase and the Cre and Flp recombinases, is the ability to recombine substrates sharing very limited DNA sequence identity.
Rajeev L, Malanowska K, Gardner JF.
europepmc   +4 more sources

Conformational dynamics promotes disordered regions from function-dispensable to essential in evolved site-specific DNA recombinases

Computational and Structural Biotechnology Journal, 2022
Protein intrinsically disordered regions (IDRs) play pivotal roles in molecular recognition and regulatory processes through structural disorder-to-order transitions.
Carla Guillén-Pingarrón, Pedro M. Guillem-Gloria, Anjali Soni, Gloria Ruiz-Gómez, Martina Augsburg, Frank Buchholz, Massimiliano Anselmi, M. Teresa Pisabarro   +7 more
doaj   +1 more source

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source