Results 31 to 40 of about 362,571 (177)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

The dif/Xer recombination systems in proteobacteria. [PDF]

PLoS ONE, 2009
In E. coli, 10 to 15% of growing bacteria produce dimeric chromosomes during DNA replication. These dimers are resolved by XerC and XerD, two tyrosine recombinases that target the 28-nucleotide motif (dif) associated with the chromosome's replication ...
Christophe Carnoy, Claude-Alain Roten
doaj   +1 more source

Study of VIPER and TATE in kinetoplastids and the evolution of tyrosine recombinase retrotransposons [PDF]

Mobile DNA, 2019
Kinetoplastids are a flagellated group of protists, including some parasites, such as Trypanosoma and Leishmania species, that can cause diseases in humans and other animals. The genomes of these species enclose a fraction of retrotransposons including VIPER and TATE, two poorly studied transposable elements that encode a tyrosine recombinase (YR) and ...
Yasmin Carla Ribeiro, Lizandra Jaqueline Robe, Danila Syriani Veluza, Cyndia Mara Bezerra dos Santos, Ana Luisa Kalb Lopes, Marco Aurélio Krieger, Adriana Ludwig   +6 more
openaire   +3 more sources

Challenging a Paradigm: the Role of DNA Homology in Tyrosine Recombinase Reactions [PDF]

Microbiology and Molecular Biology Reviews, 2009
SUMMARYA classical feature of the tyrosine recombinase family of proteins catalyzing site-specific recombination, as exemplified by the phage lambda integrase and the Cre and Flp recombinases, is the ability to recombine substrates sharing very limited DNA sequence identity.
Lara, Rajeev, Karolina, Malanowska, Jeffrey F, Gardner   +2 more
openaire   +2 more sources

The carboxy-terminal αN helix of the archaeal XerA tyrosine recombinase is a molecular switch to control site-specific recombination.

PLoS ONE, 2013
Tyrosine recombinases are conserved in the three kingdoms of life. Here we present the first crystal structure of a full-length archaeal tyrosine recombinase, XerA from Pyrococcus abyssi, at 3.0 Å resolution.
Marie-Claude Serre, Toufic El Arnaout, Mark A Brooks, Dominique Durand, Johnny Lisboa, Noureddine Lazar, Bertrand Raynal, Herman van Tilbeurgh, Sophie Quevillon-Cheruel   +8 more
doaj   +1 more source

Self‐control in DNA site‐specific recombination mediated by the tyrosine recombinase TnpI [PDF]

Molecular Microbiology, 2006
SummaryTn4430is a distinctive transposon of the Tn3family that encodes a tyrosine recombinase (TnpI) to resolve replicative transposition intermediates. The internal resolution site of Tn4430(IRS, 116 bp) contains two inverted repeats (IR1 and IR2) at the crossover core site, and two additional TnpI binding motifs (DR1 and DR2) adjacent to the core ...
Virginie, Vanhooff, Christine, Galloy, Hervé, Agaisse, Didier, Lereclus, Bernard, Révet, Bernard, Hallet   +5 more
openaire   +4 more sources

Identification and Characterization of a Phase-Variable Element That Regulates the Autotransporter UpaE in Uropathogenic Escherichia coli

mBio, 2018
Uropathogenic Escherichia coli (UPEC) is the most common etiologic agent of uncomplicated urinary tract infection (UTI). An important mechanism of gene regulation in UPEC is phase variation that involves inversion of a promoter-containing DNA element via
E. J. Battaglioli, K. G. K. Goh, T. S. Atruktsang, K. Schwartz, M. A. Schembri, R. A. Welch   +5 more
doaj   +1 more source

Evidence for a Xer/dif system for chromosome resolution in archaea. [PDF]

PLoS Genetics, 2010
Homologous recombination events between circular chromosomes, occurring during or after replication, can generate dimers that need to be converted to monomers prior to their segregation at cell division.
Diego Cortez, Sophie Quevillon-Cheruel, Simonetta Gribaldo, Nicole Desnoues, Guennadi Sezonov, Patrick Forterre, Marie-Claude Serre   +6 more
doaj   +1 more source

Simultaneous Multiplex Genome Engineering via Accelerated Natural Transformation in Bacillus subtilis

Frontiers in Microbiology, 2021
Multiplex engineering at the scale of whole genomes has become increasingly important for synthetic biology and biotechnology applications. Although several methods have been reported for engineering microbe genomes, their use is limited by their complex
Aihua Deng, Zhaopeng Sun, Tiantian Wang, Tiantian Wang, Di Cui, Lai Li, Lai Li, Shuwen Liu, Shuwen Liu, Fei Huang, Tingyi Wen, Tingyi Wen, Tingyi Wen   +12 more
doaj   +1 more source

Promoter Orientation of Prokaryotic Phase-variable Genes by PCR

Bio-Protocol, 2012
One major mechanism of phase variable gene expression in prokaryotes is through inversion of the promoter element for a gene or operon. This protocol describes how to detect the promoter orientation of a phase-variable gene by PCR.
Stacey Bateman, Patrick Seed
doaj   +1 more source