Results 41 to 50 of about 362,571 (177)
FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae. [PDF]
PLoS Genetics, 2008 Unlike most bacteria, Vibrio cholerae harbors two distinct, nonhomologous circular chromosomes (chromosome I and II). Many features of chromosome II are plasmid-like, which raised questions concerning its chromosomal nature.
Marie-Eve Val +5 more
doaj +1 more source
Prediction of designer-recombinases for DNA editing with generative deep learning
bioRxiv, 2022 Site-specific tyrosine-type recombinases are effective tools for genome engineering, with the first engineered variants having demonstrated therapeutic potential.
L. Schmitt +3 more
semanticscholar +1 more source
Initial characterization of the Pf-Int recombinase from the malaria parasite Plasmodium falciparum.
PLoS ONE, 2012 BackgroundGenetic variation is an essential means of evolution and adaptation in many organisms in response to environmental change. Certain DNA alterations can be carried out by site-specific recombinases (SSRs) that fall into two families: the serine ...
Mehdi Ghorbal +9 more
doaj +1 more source
Systematic Discovery of a New Catalogue of Tyrosine-Type Integrases in Bacterial Genomic Islands
Applied and Environmental Microbiology, 2023 Site-specific recombinases or integrases have high specificity for DNA large fragment integration, which is urgently needed for gene editing. However, known integrases are not sufficient for meeting multiple integrations.
Gang Zhang +7 more
semanticscholar +1 more source
The complete plastid genomes of the two 'dinotoms' Durinskia baltica and Kryptoperidinium foliaceum. [PDF]
PLoS ONE, 2010 In one small group of dinoflagellates, photosynthesis is carried out by a tertiary endosymbiont derived from a diatom, giving rise to a complex cell that we collectively refer to as a 'dinotom'.
Behzad Imanian +2 more
doaj +1 more source
Pairing of single mutations yields obligate Cre-type site-specific recombinases
Nucleic Acids Research, 2021 Tyrosine site-specific recombinases (SSRs) represent a versatile genome editing tool with considerable therapeutic potential. Recent developments to engineer and evolve SSRs into heterotetramers to improve target site flexibility signified a critical ...
Jenna Hoersten +7 more
semanticscholar +1 more source
Flipping chromosomes in deep-sea archaea. [PDF]
PLoS Genetics, 2017 One of the major mechanisms driving the evolution of all organisms is genomic rearrangement. In hyperthermophilic Archaea of the order Thermococcales, large chromosomal inversions occur so frequently that even closely related genomes are difficult to ...
Matteo Cossu +7 more
doaj +1 more source
PLoS ONE, 2022 The exchange of antimicrobial resistance (AMR) genes between aquaculture and terrestrial microbial populations has emerged as a serious public health concern. However, the nature of the mobile genetic elements in marine bacteria is poorly documented.
Lisa Nonaka +2 more
doaj +1 more source
The IntI-Like Tyrosine Recombinase ofShewanella oneidensisIs Active as an Integron Integrase [PDF]
Journal of Bacteriology, 2002 ABSTRACTWe have found an integron-like integrase gene and anattIsite inShewanella oneidensisas part of a small chromosomal integron. We have cloned this gene and tested the ability of the integrase to excise cassettes from various integrons. Most cassettes flanked by twoattCsites are readily excised, while cassettes in the “first” position, with ...
François, Drouin +2 more
openaire +2 more sources
PLoS ONE, 2023 The telomere resolvase, TelA, forms the hairpin telomeres of the linear chromosome of Agrobacterium tumefaciens in a process referred to as telomere resolution.
Mahrokh Balouchi +3 more
doaj +1 more source