Results 51 to 60 of about 179,081 (177)

Phasevariation in the mba gene of Ureaplasma parvum serovar 3: possible role of tyrosine recombinases?

, 2012
Diese Arbeit beschäftigt sich im ersten Teil mit dem Bakterium Ureaplasma parvum allgemein, z. B. wie es kulturell angezüchtet werden kann oder welche Krankheiten es auslösen kann.
Burger, Maria
core   +2 more sources

ALOG domains: provenance of plant homeotic and developmental regulators from the DNA-binding domain of a novel class of DIRS1-type retroposons

Biology Direct, 2012
Members of the Arabidopsis LSH1 and Oryza G1 (ALOG) family of proteins have been shown to function as key developmental regulators in land plants. However, their precise mode of action remains unclear.
Iyer Lakshminarayan M, Aravind L
doaj   +1 more source

Mobile Element Integration Reveals a Chromosome Dimer Resolution System in Legionellales

mBio, 2022
In bacteria, the mechanisms used to repair DNA lesions during genome replication include homologous recombination between sister chromosomes. This can lead to the formation of chromosome dimers if an odd number of crossover events occurs. The dimers must
Beth Nicholson, Shayna R. Deecker, Alexander W. Ensminger   +2 more
doaj   +1 more source

Mechanistic Insights Into Filamentous Phage Integration In Vibrio cholerae

Frontiers in Microbiology, 2014
Vibrio cholerae, the etiological agent of acute diarrhoeal disease cholera, harbors large numbers of lysogenic filamentous phages, contribute significantly to the host pathogenesis and provide fitness factors to the pathogen that help the bacterium to ...
Bhabatosh eDas
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Dinoroseobacter shibae Outer Membrane Vesicles Are Enriched for the Chromosome Dimer Resolution Site dif

mSystems, 2021
Outer membrane vesicles (OMVs) are universally produced by prokaryotes and play important roles in symbiotic and pathogenic interactions. They often contain DNA, but a mechanism for its incorporation is lacking. Here, we show that Dinoroseobacter shibae,
Hui Wang, Nicole Beier, Christian Boedeker, Helena Sztajer, Petra Henke, Meina Neumann-Schaal, Johannes Mansky, Manfred Rohde, Jörg Overmann, Jörn Petersen, Frank Klawonn, Martin Kucklick, Susanne Engelmann, Jürgen Tomasch, Irene Wagner-Döbler   +14 more
doaj   +1 more source

In vitro site‐specific recombination mediated by the tyrosine recombinase XerA of Thermoplasma acidophilum [PDF]

Genes to Cells, 2017
In organisms with circular chromosomes, such as bacteria and archaea, an odd number of homologous recombination events can generate a chromosome dimer. Such chromosome dimers cannot be segregated unless they are converted to monomers before cell division.
Minji Jo, Yasuto Murayama, Yasuhiro Tsutsui, Hiroshi Iwasaki   +3 more
openaire   +2 more sources

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

FtsK, a DNA Motor Protein, Coordinates the Genome Segregation and Early Cell Division Processes in Deinococcus radiodurans

mBio, 2022
Filament temperature-sensitive mutant K (FtsK)/SpoIIIE family proteins are DNA translocases known as the fastest DNA motor proteins that use ATP for their movement on DNA.
Shruti Mishra, Hari S. Misra, Swathi Kota   +2 more
doaj   +1 more source

Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Homologous recombination provides the most accurate means to repair genotoxic DNA lesions. It depends on the assembly of the RAD51 DNA strand exchange protein into a dynamic nucleoprotein filament. The c-Abl tyrosine kinase and its oncogenic counterpart BCR-ABL control RAD51 by phosphorylating tyrosine residues 54 and 315.
Shyamal Subramanyam, Mohammed Ismail, Ipshita Bhattacharya, Maria Spies   +3 more
openaire   +2 more sources