Results 1 to 10 of about 530,778 (295)

Analysis of Recombinant Characteristics Based on 949 PRRSV-2 Genomic Sequences Obtained from 1991 to 2021 Shows That Viral Multiplication Ability Contributes to Dominant Recombination

Microbiology Spectrum, 2022
Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important diseases affecting the pig-raising industry. The PRRS virus (PRRSV) has high genetic diversity, partly owing to viral recombination.
Xingyang Cui, Dasong Xia, Xinyi Huang, Yue Sun, Mang Shi, Jianqiang Zhang, Ganwu Li, Yongbo Yang, Haiwei Wang, Xuehui Cai, Tongqing An   +10 more
doaj   +1 more source

Elements in the 5′ Untranslated Region of Viral RNA Important for HIV Gag Recognition and Cross-Packaging

Viruses
During retrovirus assembly, Gag packages unspliced viral RNA as the virion genome. Genome packaging is usually specific with occasional exceptions of cross-packaging RNA from distantly related retroviruses.
Zetao Cheng, Olga A. Nikolaitchik, Alice Duchon, Jonathan M. O. Rawson, Vinay K. Pathak, Wei-Shau Hu   +5 more
doaj   +1 more source

How to recover from a bad start: adaptation of HIV-1 transcription start site mutants during serial passaging in culture

Journal of Virology
HIV-1 uses neighboring sequences as transcription start sites and generates multiple unspliced transcripts, including two major transcripts with three guanosines (3G) or one guanosine (1G) at the 5′ end. Although only differing by 2-nt, 3G RNA and 1G RNA
Olga A. Nikolaitchik, Akhil Chameettachal, Saiful Islam, Zetao Cheng, Krista Delviks-Frankenberry, Brandon F. Keele, Vinay K. Pathak, Wei-Shau Hu   +7 more
doaj   +1 more source

A novel motif of Rad51 serves as an interaction hub for recombination auxiliary factors

eLife, 2021
Homologous recombination (HR) is essential for maintaining genome stability. Although Rad51 is the key protein that drives HR, multiple auxiliary factors interact with Rad51 to potentiate its activity.
Negar Afshar, Bilge Argunhan, Maierdan Palihati, Goki Taniguchi, Hideo Tsubouchi, Hiroshi Iwasaki   +5 more
doaj   +1 more source

Mismatch Repair: From Preserving Genome Stability to Enabling Mutation Studies in Real-Time Single Cells

Cells, 2021
Mismatch Repair (MMR) is an important and conserved keeper of the maintenance of genetic information. Miroslav Radman’s contributions to the field of MMR are multiple and tremendous.
Marina Elez
doaj   +1 more source

HIV-1 RNA genome packaging: it’s G-rated

mBio
A member of the Retroviridae, human immunodeficiency virus type 1 (HIV-1), uses the RNA genome packaged into nascent virions to transfer genetic information to its progeny.
Alice Duchon, Wei-Shau Hu
doaj   +1 more source

Elucidating Recombination Mediator Function Using Biophysical Tools

Biology, 2021
The recombination mediator proteins (RMPs) are ubiquitous and play a crucial role in genome stability. RMPs facilitate the loading of recombinases like RecA onto single-stranded (ss) DNA coated by single-strand binding proteins like SSB.
Camille Henry, Sarah S. Henrikus
doaj   +1 more source

The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy

Frontiers in Immunology, 2018
Tumors are composed of abnormally transformed cell types and tissues that differ from normal tissues in their genetic and epigenetic makeup, metabolism, and immunology.
Lilla Hornyák, Nikoletta Dobos, Gábor Koncz, Zsolt Karányi, Zsolt Karányi, Dénes Páll, Zoltán Szabó, Gábor Halmos, Lóránt Székvölgyi   +8 more
doaj   +1 more source

Whole Genome Sequencing of Infectious Bursal Disease Viruses Isolated from a Californian Outbreak Unravels the Underlying Virulence Markers and Highlights Positive Selection Incidence

Viruses, 2023
Outbreaks of the immunosuppressive infectious bursal disease (IBD) are frequently reported worldwide, despite the vaccination regimes. A 2009 Californian IBD outbreak caused by rA and rB isolates was described as very virulent (vv) IBD virus (IBDV ...
Islam Nour, Julia R. Blakey, Sonsiray Alvarez-Narvaez, Sujit K. Mohanty   +3 more
doaj   +1 more source

Genomic Patterns of Introgression in Interspecific Populations Created by Crossing Wheat with Its Wild Relative

G3: Genes, Genomes, Genetics, 2020
Introgression from wild relatives is a valuable source of novel allelic diversity for breeding. We investigated the genomic patterns of introgression from Aegilops tauschii, the diploid ancestor of the wheat D genome, into winter wheat (Triticum aestivum)
Moses Nyine, Elina Adhikari, Marshall Clinesmith, Katherine W. Jordan, Allan K. Fritz, Eduard Akhunov   +5 more
doaj   +1 more source