Results 41 to 50 of about 1,036,111 (281)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Accelerated Recombination due to Resonant Deexcitation of Metastable States

, 2001
In a recombining plasma the metastable states are known to accumulate population thereby slowing down the recombination process. We show that an account of the doubly-excited autoionizing states, formed due to collisional recombination of metastable ions,
Apruzese, Bell, Bernshtam, Cacciatore, Clark, Cowan, Drayson, Elton, Fisher, Fisher, Fisher, Fujimoto, Fujimoto, Gorse, Griem, Griem, Hahn, Jacoby, Kawachi, Kawachi, Koshelev, Koshelev, Lee, Lennon, Lotz, Mazzotta, Murillo, Müller, Parpia, Ralchenko, Shevelko, Verner   +31 more
core   +2 more sources

Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending [PDF]

, 2016
Bacterial Xer site-specific recombinases play an essential genome maintenance role by unlinking chromosome multimers, but their mechanism of action has remained structurally uncharacterized. Here, we present two high-resolution structures of Helicobacter
Adams, Afonine, Aihara, Arnold, Aussel, Barre, Barre, Biswas, Blakely, Blakely, Blakely, Britton, Carnoy, Chen, Cortez, Das, Debowski, Debowski, Diagne, Dong, Emsley, Ennifar, Fischer, Gopaul, Gopaul, Grainge, Grindley, Guo, Guo, Hendricks, Holliday, Jayaram, Jo, Kabsch, Karaca, Keller, Kelley, Kim, Krissinel, Kuempel, Le Bourgeois, Lee, Leroux, Li, Luscombe, May, McCoy, Midonet, Nagy, Nolivos, Nunes-Düby, Page, Pargellis, Pettersen, Pérals, Rother, Serre, Steiner, Subramanya, Terwilliger, Turan, Val, Van Duyne, Van Duyne, van Zundert, Vonrhein, Yang, Yang, Yates, Yates, Zawadzki, Zheng   +71 more
core   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Auger recombination rates in ZnMgO from first principles [PDF]

, 2011
We investigate direct electron-electron-hole interband Auger recombination for wurtzite Zn(1-x)Mg(x)O alloys in the range 0
Heiliger, Christian, Heinemann, Markus
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Remarkable Evolutionary Plasticity of Coronaviruses by Mutation and Recombination: Insights for the COVID-19 Pandemic and the Future Evolutionary Paths of SARS-CoV-2

Viruses, 2022
Coronaviruses (CoVs) constitute a large and diverse subfamily of positive-sense single-stranded RNA viruses. They are found in many mammals and birds and have great importance for the health of humans and farm animals. The current SARS-CoV-2 pandemic, as
Grigorios D. Amoutzias, Marios Nikolaidis, Eleni Tryfonopoulou, Katerina Chlichlia, Panayotis Markoulatos, Stephen G. Oliver   +5 more
doaj   +1 more source

Could the Cosmological Recombination Spectrum Help Us Understand Annihilating Dark Matter?

, 2009
In this paper we explore the potential effects of DM annihilations on the cosmological recombination spectrum. With this example we want to demonstrate that the cosmological recombination spectrum in principle is sensitive to details related to possible ...
Abdo, Adriani, Arkani-Hamed, Bean, Bean, Burigana, Carr, Chang, Chen, Chluba, Chluba, Chluba, Chluba, Chluba, Chluba, Chluba, Chluba, Chluba, Chluba, Cirelli, Colombo, Doran, Dubrovich, Dubrovich, Fendt, Fixsen, Galli, Galli, Galli, Hirata, Hirata, Holder, Hooper, Hu, Huetsi, Illarionov, Illarionov, J. Chluba, Jasche, Kholupenko, Komatsu, Komatsu, Mapelli, Mather, McDonald, Molnar, Ostriker, Padmanabhan, Peebles, Peebles, Refregier, Rubiño-Martín, Rubiño-Martín, Schleicher, Seager, Seager, Shull, Shull, Slatyer, Sunyaev, Sunyaev, Sunyaev, Switzer, Switzer, Vonlanthen, Wong, Zeldovich, Zeldovich, Zhang, Zhang   +69 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source