Results 61 to 70 of about 9,223,247 (288)

Integration of Langerhans Cells into a Pigmented Reconstructed Human Epidermis

Journal of Investigative Dermatology, 1997
The majority of in vitro reconstructed human epidermis is composed of keratinocytes only. Recently, the introduction of melanocytes into epidermal reconstructs has enlarged their field of application. The completion of reconstructed epidermis by introducing Langerhans cells remained an important challenge because Langerhans cells, unlike the other ...
Régnier, Marcelle, Staquet, Marie-Jeanne, Schmitt, Daniel, Schimdt, Rainer   +3 more
openaire   +2 more sources

Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of Staphylococcus aureus Adhesion by Fucoidan

Dermatopathology, 2021
Atopic dermatitis is a multifactorial pathology that includes perturbations of gene expression and increased adhesion of Staphylococcus aureus. Fucoidans are seaweed-derived sulfated fucose-rich polysaccharides that are known to be anti-inflammatory and ...
Ah Young Park, Maureen Bourtembourg, Aline Chrétien, Roland Hubaux, Céline Lancelot, Michel Salmon, J. Helen Fitton   +6 more
doaj   +1 more source

Malassezia interaction with a reconstructed human epidermis: imaging studies [PDF]

, 2019
ABSTRACT Background Biofilm formation represents a major microbial virulence attribute especially at epithelial surfaces such as the skin. Malassezia biofilm formation at the skin surface has not yet been addressed.
Pedrosa, AF, Lisboa, C, Branco, J, Almeida, AC, Mendes, C, Pellevoisin, C, Leite-Moreira, A, Miranda, IM, Rodrigues, AG   +8 more
openaire   +1 more source

The Reconstructed Human Epidermis in vitro — a Model for Basic and Applied Research of Human Skin

Vestnik Dermatologii i Venerologii, 2020
Background. The reconstructed human epidermis (RE) is an in vitro tissue-engineering construct similar to the native epidermis. Objective. To develop a full-layer RE.
Arkadii K. Beilin, Alexandra L. Rippa, Valentin I. Sharobaro, Nadejda G. Gurskaya, Ekaterina A. Vorotelyak   +4 more
doaj   +1 more source

Epicutaneous challenge with protease allergen requires its protease activity to recall TH2 and TH17/TH22 responses in mice pre-sensitized via distant skin

Journal of Immunotoxicology, 2021
Epicutaneous exposure to allergenic proteins is an important sensitization route for skin diseases like protein contact dermatitis, immunologic contact urticaria, and atopic dermatitis.
Akira Ogasawara, Takuo Yuki, Toshiro Takai, Kyosuke Yokozeki, Asuka Katagiri, Yutaka Takahashi, Hiroo Yokozeki, David Basketter, Hitoshi Sakaguchi   +8 more
doaj   +1 more source

Implementation, availability and regulatory status of an OECD accepted Reconstructed Human Epidermis model in Brazil

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018
Introduction: In 2014, Brazil has joined the growing list of countries to ban cosmetic products from being tested on animal models. The new legislation comes into force in 2019.
Rodrigo De Vecchi, Vanja Dakic, Guilherme Mattos, Anne-Sophie Rigaudeau, Veronica Oliveira, Cristina Garcia, Nathalie Alépée, José Cotovio, Charbel Bouez   +8 more
doaj   +7 more sources

Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis

Neurobiology of Aging, 2022
Aged and photoaged skin exhibit fine wrinkles that are signs of epidermal inflammation and degeneration. It has been shown that healthy elderly skin expresses amyloidogenic proteins, including α-Synuclein, which are known to oligomerize and trigger inflammation and neurodegeneration. However, little is known about their putative role in skin physiology
Júlia T. Oliveira, Vanja Dakic, Gabriela Vitória, Carolina da S.G. Pedrosa, Mayara Mendes, Luiz Guilherme H.S. Aragão, Thyago R. Cardim-Pires, Damien Lelièvre, Daniel Rodrigues Furtado, Roberta O. Pinheiro, Débora Foguel, Lionel Breton, Charbel Bouez, Rodrigo De Vecchi, Marília Zaluar P. Guimarães, Stevens Rehen   +15 more
openaire   +2 more sources

Fifty-kDa Hyaluronic Acid Upregulates Some Epidermal Genes without Changing TNF-α Expression in Reconstituted Epidermis [PDF]

, 2011
Background: Due to its strong water binding potential, hyaluronic acid (HA) is a well-known active ingredient for cosmetic applications. However, based on its varying molecular size, skin penetration of HA may be limited. Recent studies have demonstrated
T. Pavicic, V. Tarabin, Korting, Hans Christian, Malle, B., Pavicic, T., G. Gauglitz, T. Köhler, Korting, H. C., Tarabin, V., Wegmann, M., B. Malle, M. Wegmann, G. Schmitz, Schmitz, G., M. Farwick, Gauglitz, Gerd, K. Schwach-Abdellaoui, Malle, D., Schmitz, Gerd, Schwach-Abdellaoui, K., Gauglitz, G., Köhler, T., Farwick, M., H.C. Korting   +23 more
core   +1 more source

Optimizing photopollution assessment: Insights from a reconstructed human epidermis model

International Journal of Pharmaceutics
The Reconstructed Human Epidermis (RHE) model offers a significant in vitro alternative to animal testing for cosmetic safety and efficacy. This physiologically relevant system evaluates skin responses, meeting ethical, scientific, and regulatory demands. It is particularly useful for studying ultraviolet radiation (UV) and air pollution, key stressors
Maria da Graça Landim Bravo, Isadora de Jesus da Silva, Nayara Fernanda Tokashike de Araújo, Gabriel Neves Cezarette, Ludmilla Tonani, Márcia Regina von Zeska Kress, Rodrigo De Vecchi, Vanja Dakić, Lorena Rigo Gaspar   +8 more
openalex   +3 more sources

Fiber‐Based Wearable Electronics as Adaptive Biointerfaces for Healthcare Applications

Advanced Functional Materials, EarlyView.
Fiber‐based wearable electronics have been extensively studied as adaptive healthcare biointerfaces. In this review, we classify and introduce fiber‐based systems according to biointerface design, conductive materials, transduction mechanisms, and healthcare applications, and provide a perspective on their translation toward reliable, continuous ...
Sangwoo Hong, Jinsol Kim, Yoonjae Jeong, Sejong Kang, Daeho Lee, Seung Hwan Ko   +5 more
wiley   +1 more source