Results 51 to 60 of about 9,223,247 (288)
Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis. [PDF]
J Invest Dermatol, 2019 International audienceDeimination, a post-translational modification catalyzed by a family of enzymes called peptidylarginine deiminases (PADs), is the conversion of arginine into citrulline residues in a protein.
Cau L +5 more
europepmc +3 more sources
Human Epidermis Reconstructed by Culture: Is It “Normal”?
Journal of Investigative Dermatology, 1986 Human keratinocytes were grown on a dermal equivalent (or lattice) at the liquid-air interface in an attempt to reconstitute a functional epidermis in vitro. Although the multilayered epithelium thus obtained is well differentiated, as shown by the presence of keratohyaline granules and horny layer, several differences from its in vivo counterpart were
Asselineau, Daniel +4 more
openaire +2 more sources
ALTEX: Alternatives to Animal Experimentation, 2018 To protect the human skin from extensive solar radiation, melanocytes produce melanin and disperse it via melanosomes to keratinocytes in the basal and suprabasal layers of the human epidermis.
Freia F. Schmid +6 more
doaj +1 more source
ALTEX: Alternatives to Animal Experimentation, 2007 SkinEthic Laboratories is a France-based biotechnology company recognised as the world leader in tissue engineering. SkinEthic is devoted to develop and produce reliable and robust in vitro alternative methods to animal use in cosmetic, chemical and ...
Anne de Brugerolle
doaj +1 more source
Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis. [PDF]
Ann Dermatol, 2019 Atopic dermatitis (AD) is a chronic disorder, with a vicious cycle of repetitive inflammation and deterioration of the epidermal barrier function. Adiponectin, an adipokine, has anti-inflammatory effects on various metabolic and inflammatory disorders. Recently, its level was found to be reduced in serum and tissue samples from AD patients.We aimed to ...
Seo HS +6 more
europepmc +4 more sources
Reconstructed human epidermis: A model to study the barrier function
, 2020 The use of in vitro reconstructed human epidermis (RHE) by the cosmetic and pharmaceutical industries is increasing because of its similar physiological mechanisms to native human skin.
De Wever, B. +11 more
core +1 more source
Inflammation modulates intercellular adhesion and mechanotransduction in human epidermis via ROCK2
iScience, 2023 Summary: Aberrant mechanotransduction and compromised epithelial barrier function are associated with numerous human pathologies including inflammatory skin disorders.
Maria S. Shutova +9 more
doaj +1 more source
Toxics, 2021 Biocides are commonly used as spray- or trigger-type formulations, thus dermal and respiratory exposure to biocide aerosol is unavoidable. However, little is known about the impact of aerosolization on the local toxicity of biocides on the skin or the ...
Nahyun Lee +6 more
doaj +1 more source
Immunomodulatory mechanisms of action of calcitriol in psoriasis
Indian Journal of Dermatology, 2014 Background: Calcitriol is well known for its therapeutic efficacy in psoriasis, but its mechanism of action is still unclear. In this study, we tried to elucidate the precise mechanism of calcitriol for its therapeutic efficacy in psoriasis.
Suravi Raychaudhuri +2 more
doaj +1 more source
Cosmetics, 2021 Recent publications describe various skin disorders in relation to phototypes and aging. The highest phototypes (III to VI) are more sensitive to acne, with the appearance of dark spots due to the inflammation induced by Cutibacterium acnes (previously ...
Christophe Capallere +3 more
doaj +1 more source