Results 31 to 40 of about 9,223,247 (288)

Knockdown of Filaggrin in a Three-Dimensional Reconstructed Human Epidermis Impairs Keratinocyte Differentiation [PDF]

Journal of Investigative Dermatology, 2014
Atopic dermatitis is a chronic inflammatory skin disorder characterized by defects in the epidermal barrier and keratinocyte differentiation. The expression of filaggrin, a protein thought to have a major role in the function of the epidermis, is downregulated. However, the impact of this deficiency on keratinocytes is not really known.
Pendaries, Valérie, Malaisse, Jeremy, Pellerin, Laurence, Le Lamer, Marina, Nachat, Rachida, Kezic, Sanja, Schmitt, Anne-Marie, Paul, Carle F, Poumay, Yves, Serre, Guy, Simon, Michel   +10 more
openaire   +5 more sources

Replacing HaCaT keratinocytes with 3D reconstructed human epidermis in a THP-1 coculture dendritic cell activation assay: quantitative skin sensitization potency assessment and structure–potency relationships [PDF]

NAM J
Blömeke B, Peter N, Bock U, Müller B, Griem P, Wittlake R, Panten J.   +6 more
europepmc   +3 more sources

Use of a 3D Model with Reconstructed Human Epidermis Infected with Fungi and Covered with a Bovine Nail to Simulate Onychomycosis and to Evaluate the Effects of Antifungal Agents. [PDF]

J Fungi (Basel)
Urso FG, Del Prete S, Foucher C, Barberis M, Carriero F, Bart A.   +5 more
europepmc   +3 more sources

Xanthophyll-Rich Extract of Phaeodactylum tricornutum Bohlin as New Photoprotective Cosmeceutical Agent: Safety and Efficacy Assessment on In Vitro Reconstructed Human Epidermis Model. [PDF]

Molecules, 2023
Smeriglio A, Lionti J, Ingegneri M, Burlando B, Cornara L, Grillo F, Mastracci L, Trombetta D.   +7 more
europepmc   +3 more sources

An Inflamed and Infected Reconstructed Human Epidermis to Study Atopic Dermatitis and Skin Care Ingredients. [PDF]

Int J Mol Sci, 2022
Cadau S, Gault M, Berthelemy N, Hsu CY, Danoux L, Pelletier N, Goudounèche D, Pons C, Leprince C, André-Frei V, Simon M, Pain S.   +11 more
europepmc   +3 more sources

Probing skin photoallergens in reconstructed human epidermis: An EPR spin trapping investigation. [PDF]

Photochem Photobiol
Port-Lougarre Y, Voegeli G, Vileno B, Giménez-Arnau E.   +3 more
europepmc   +3 more sources

A Mixture of Water-Soluble Polysaccharides Reduces Caspase-1 and IL-1β Inflammatory Responses by Cutibacterium acnes in vitro in Reconstructed Human Epidermis (RHE). [PDF]

Clin Cosmet Investig Dermatol
Gruber JV, Terpak N, Massard S, Chen X, Kim Y.   +4 more
europepmc   +3 more sources

Characterization and applications of human epidermis reconstructed in vitro on de-epidermized derma

Il Farmaco, 1998
In recent years in vitro models have been developed to avoid the use of animals in cutaneous toxicological studies. Submerged human keratinocyte cultures in vitro could be so far employed as an alternative to animal testing and a good correlation between skin irritation and cytotoxicity has been demonstrated.
PARNIGOTTO, PIER PAOLO, BERNUZZO S, BRUNO P, CONCONI, MARIA TERESA, MONTESI F.   +4 more
openaire   +4 more sources

Noninvasive evaluation of the skin barrier in reconstructed human epidermis using speckle analysis: Correlation with Raman microspectroscopy. [PDF]

Skin Res Technol
Habib L, Nassif LA, Abboud M, Michael-Jubeli R, Tfayli A, Lteif R.   +5 more
europepmc   +3 more sources

Deletion of TNFAIP6 Gene in Human Keratinocytes Demonstrates a Role for TSG-6 to Retain Hyaluronan Inside Epidermis

JID Innovations, 2021
TSG-6 is a soluble protein secreted in the extracellular matrix by various cell types in response to inflammatory stimuli. TSG-6 interacts with extracellular matrix molecules, particularly hyaluronan (HA), and promotes cutaneous wound closure in mice ...
Céline Evrard, Emilie Faway, Evelyne De Vuyst, Olivier Svensek, Valérie De Glas, David Bergerat, Michel Salmon, Olivier De Backer, Bruno Flamion, Hélène Le-Buanec, Catherine Lambert de Rouvroit, Yves Poumay   +11 more
doaj   +1 more source