Results 41 to 50 of about 7,690,139 (265)

Reconstructed human epidermis: A model to study the barrier function

, 2020
The use of in vitro reconstructed human epidermis (RHE) by the cosmetic and pharmaceutical industries is increasing because of its similar physiological mechanisms to native human skin.
De Wever, B., Barbotteau, Y., Smith, Richard, Moretto, P., Pouthier, T., Incerti, S., Barbaret, P., Mavon, A., Ynsa, M.D, Cappadoro, M., Habchi, C., Gontier, E.   +11 more
core   +1 more source

Modulation of Gene Expression in a Sterile Atopic Dermatitis Model and Inhibition of Staphylococcus aureus Adhesion by Fucoidan

Dermatopathology, 2021
Atopic dermatitis is a multifactorial pathology that includes perturbations of gene expression and increased adhesion of Staphylococcus aureus. Fucoidans are seaweed-derived sulfated fucose-rich polysaccharides that are known to be anti-inflammatory and ...
Ah Young Park, Maureen Bourtembourg, Aline Chrétien, Roland Hubaux, Céline Lancelot, Michel Salmon, J. Helen Fitton   +6 more
doaj   +1 more source

New Acylceramide in Native and Reconstructed Epidermis [PDF]

, 2003
Culturing of normal human keratinocytes at the air–liquid interface results in the formation of fully differentiated epidermis under in vitro conditions.
Wertz, Phil, Phil Wertz, Maria Ponec, Peter Lankhorst, Arij Weerheim, Lankhorst, Peter, Weerheim, Arij, Ponec, Maria   +7 more
core   +1 more source

The Reconstructed Human Epidermis in vitro — a Model for Basic and Applied Research of Human Skin

Vestnik Dermatologii i Venerologii, 2020
Background. The reconstructed human epidermis (RE) is an in vitro tissue-engineering construct similar to the native epidermis. Objective. To develop a full-layer RE.
Arkadii K. Beilin, Alexandra L. Rippa, Valentin I. Sharobaro, Nadejda G. Gurskaya, Ekaterina A. Vorotelyak   +4 more
doaj   +1 more source

Epicutaneous challenge with protease allergen requires its protease activity to recall TH2 and TH17/TH22 responses in mice pre-sensitized via distant skin

Journal of Immunotoxicology, 2021
Epicutaneous exposure to allergenic proteins is an important sensitization route for skin diseases like protein contact dermatitis, immunologic contact urticaria, and atopic dermatitis.
Akira Ogasawara, Takuo Yuki, Toshiro Takai, Kyosuke Yokozeki, Asuka Katagiri, Yutaka Takahashi, Hiroo Yokozeki, David Basketter, Hitoshi Sakaguchi   +8 more
doaj   +1 more source

Malassezia interaction with a reconstructed human epidermis: imaging studies [PDF]

, 2019
ABSTRACT Background Biofilm formation represents a major microbial virulence attribute especially at epithelial surfaces such as the skin. Malassezia biofilm formation at the skin surface has not yet been addressed.
Pedrosa, AF, Lisboa, C, Branco, J, Almeida, AC, Mendes, C, Pellevoisin, C, Leite-Moreira, A, Miranda, IM, Rodrigues, AG   +8 more
openaire   +1 more source

Protection of normal human reconstructed epidermis from UV by catalase overexpression [PDF]

Cancer Gene Therapy, 2006
Reactive oxygen species (ROS) generated by ultraviolet (UV) irradiation are counterbalanced by endogenous antioxidant systems. To test the hypothesis of a novel photoprotective approach, we irradiated epidermis reconstructed with normal human keratinocytes overexpressing sustainably lentivirus-mediated catalase (CAT), copper/zinc superoxide dismutase ...
H R, Rezvani, M, Cario-André, C, Pain, C, Ged, H, deVerneuil, A, Taïeb   +5 more
openaire   +2 more sources

Oligomeric α-Synuclein induces skin degeneration in reconstructed human epidermis

Neurobiology of Aging, 2022
Aged and photoaged skin exhibit fine wrinkles that are signs of epidermal inflammation and degeneration. It has been shown that healthy elderly skin expresses amyloidogenic proteins, including α-Synuclein, which are known to oligomerize and trigger inflammation and neurodegeneration. However, little is known about their putative role in skin physiology
Júlia T. Oliveira, Vanja Dakic, Gabriela Vitória, Carolina da S.G. Pedrosa, Mayara Mendes, Luiz Guilherme H.S. Aragão, Thyago R. Cardim-Pires, Damien Lelièvre, Daniel Rodrigues Furtado, Roberta O. Pinheiro, Débora Foguel, Lionel Breton, Charbel Bouez, Rodrigo De Vecchi, Marília Zaluar P. Guimarães, Stevens Rehen   +15 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Responses of reconstructed human epidermis to Trichophyton rubrum infection and impairment of infection by the inhibitor PD169316

, 2019
Data collected in the project MycAvert in order to assess infection of reconstructed human epidermis and tissue response during infection by ...
Faway, Émilie, Namur Research Institute for Life Sciences, Faculty of Medicine, URPHYM, Poumay, Yves; id_orcid   +4 more
core   +3 more sources