Results 71 to 80 of about 7,690,139 (265)

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source

In Vitro Investigation of Traditional Medicine Recipes Used in Bukavu (DR-Congo) to Treat Trichophyton rubrum Dermatophytosis

Microbiology Research
Twenty natural products used in traditional medicine to treat dermatophytosis were evaluated for their efficacy against Trichophyton rubrum, the most frequent dermatophyte infecting humans.
Alexis Cizungu Murhula, Valérie De Glas, Eléa Denil, Yves Poumay   +3 more
doaj   +1 more source

Knockdown of Filaggrin in a Three-Dimensional Reconstructed Human Epidermis Impairs Keratinocyte Differentiation [PDF]

Journal of Investigative Dermatology, 2014
Atopic dermatitis is a chronic inflammatory skin disorder characterized by defects in the epidermal barrier and keratinocyte differentiation. The expression of filaggrin, a protein thought to have a major role in the function of the epidermis, is downregulated. However, the impact of this deficiency on keratinocytes is not really known.
Pendaries, Valérie, Malaisse, Jeremy, Pellerin, Laurence, Le Lamer, Marina, Nachat, Rachida, Kezic, Sanja, Schmitt, Anne-Marie, Paul, Carle F, Poumay, Yves, Serre, Guy, Simon, Michel   +10 more
openaire   +4 more sources

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

Advanced Materials, EarlyView.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn, Min‐seop Kim, Ju‐Hee Kim, Seok‐Hyeon Kang, Dain Lee, Hui‐Wen Liu, Seung‐cheol Shin, Kyuhwan Na, Yesl Jun, Oak‐Kee Hong, Ji Hun Yang, Jin‐A Kim, Hwanseok Jang, Hong Nam Kim, Roger D. Kamm, Ji‐Hoon Kim, Jang‐Won Son, Seok Chung   +17 more
wiley   +1 more source

Differential impacts of nickel toxicity: NiO and NiSO4 on skin health and barrier function

Ecotoxicology and Environmental Safety
Nickel is recognized as a potent skin sensitizer and a common cause of contact dermatitis. Nickel and its compounds are often associated with particulate matter in industrial settings.
Denisse Esther Mallaupoma Camarena, Mariana Corrêa Giannella, Julia de Toledo Bagatin, Silvia Romano de Assis, Tao Chen, Melanie Jane Bailey, Catia Costa, Ella Schneider, Johanna von Gerichten, Silvia Berlanga de Moraes Barros, Natalie Belsey, Silvya Stuchi Maria-Engler   +11 more
doaj   +1 more source

Skin Concentrations of Topically Applied Substances in Reconstructed Human Epidermis (RHE) Compared with Human Skin Using in vivo Confocal Raman Microscopy

CHIMIA, 2015
Detailed knowledge about the skin concentration of topically applied substances is important to understand their local pharmacological activity. In particular since in vitro models of reconstructed human epidermis are increasingly used as models
Franziska D. Fleischli, Fabienne Morf, Christian Adlhart   +2 more
doaj   +1 more source

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Wosikowski, K., Probst, C., Sander, C. A., Degitz, K., Schuh, T., Flaig, M. J., Braungart, E., Douwes, K., Magdolen, V., C.A. Sander, C. Probst, K. Wosikowski, K. Degitz, T. Schuh, R. Besch, E. Braungart, V. Magdolen, M.J. Flaig, K. Douwes   +19 more
core   +2 more sources

Inflammatory reactivity of reconstructed human epidermis to metal haptens by integration of TLR4-positive cells

, 2022
S.e16Allergic contact dermatitis is critically determined by the ability of haptens to mount an innate immune signal additionally to a directed T cell response.
Frings, Verena Gerlinde, Müller, Daniel, Storz, G., Goebeler, Matthias, Sennefelder, H., Adam, C., Groeber-Becker, Florian Kai, Schmidt, M.   +7 more
core   +1 more source

3D Printing of Self‐Healing Polymers by Material Extrusion: A Process‐Centric Review of Setups, Parameters, and Applications

Advanced Robotics Research, EarlyView.
This review highlights recent advances in material extrusion 3D printing of self‐healing polymers, focusing on the interplay between material chemistry, rheology, hardware customization, and process optimization. Filament‐ and ink‐based extrusion strategies, multimaterial architectures, and postprocessing approaches are discussed for applications in ...
Antonio Pavone, Gianni Stano, Gianluca Percoco   +2 more
wiley   +1 more source

Skin toxicity of lead iodide perovskites evaluated using human skin cell and tissue models [PDF]

Materials Advances
Perovskite solar cells based on organic–inorganic lead halide materials are advancing toward practical implementation, yet their potential risks to human health remain insufficiently understood, particularly in relation to direct skin contact during ...
Masafumi Koremura, Nao Saito, Masashi Ikegami, Tsutomu Miyasaka, Kaoru Yoshida   +4 more
doaj   +1 more source