Results 51 to 60 of about 970,952 (293)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents

Frontiers in Neural Circuits
Descending neural pathways to the spinal cord plays vital roles in motor control. They are often damaged by brain injuries such as stroke and trauma, which lead to severe motor impairments.
Takahiro Inoue, Masaki Ueno
doaj   +1 more source

Hypertrophic degeneration of the inferior olivary nucleus impacts perception of gravity

Frontiers in Neurology, 2012
Interruption of the Guillain-Mollaret triangle interconnecting the red nucleus, the inferior olivary nucleus and the contralateral dentate nucleus is predicted to interfere with the dentate nucleus’ role in estimating direction of gravity.
Alexander A Tarnutzer, Antonella ePalla, Sarah eMarti, Bernhard eSchuknecht, Dominik eStraumann   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Evolution of red algal plastid genomes: ancient architectures, introns, horizontal gene transfer, and taxonomic utility of plastid markers. [PDF]

PLoS ONE, 2013
Red algae have the most gene-rich plastid genomes known, but despite their evolutionary importance these genomes remain poorly sampled. Here we characterize three complete and one partial plastid genome from a diverse range of florideophytes. By unifying
Jan Janouškovec, Shao-Lun Liu, Patrick T Martone, Wilfrid Carré, Catherine Leblanc, Jonas Collén, Patrick J Keeling   +6 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Periaqueductal gray matter echogenicity as a marker of migraine chronification: a case control study

The Journal of Headache and Pain, 2023
Background Migraine is one of the most prevalent and disabling medical diseases in the world. The periaqueductal gray matter and the red nucleus play an important role in its pathogenesis.
Dolores Vilas, Sara Rubio, Mireia Gea, Jose Rios, Lourdes Ispierto, María Hernández-Pérez, Martí Paré, Mònica Millán, Laura Dorado   +8 more
doaj   +1 more source

Molecular Gas in the Powerful Radio Nucleus of the Ultraluminous Infrared Galaxy PKS 1345+12 [PDF]

, 1999
Millimeter CO(1-0) interferometry and high resolution, Hubble Space Telescope (HST) 1.1, 1.6, and 2.2 micron imaging of the radio compact galaxy PKS 1345+12 are presented.
A. S. Evans, D. B. Sanders, D. C. Kim, de Grijp M. H. K., J. M. Mazzarella, Joseph R. D., N. Z. Scoville, Shepherd M. C., Steppe H., Strong A. W.   +9 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Artefactual Suboptimal Fixation Effect to Nuclear Staining on Erythrocytes of Lutjanus kasmira (Forsskål 1775)

Hayati Journal of Biosciences, 2022
This research presents the unusual staining characteristic of the teleosts red blood cells–the common bluestripe snapper Lutjanus kasmira, caught at Toc Tan (Allison) Reef, Truong Sa Archipelago, Vietnam, due to side effects of the delayed staining ...
Huu-Quyet Do, Van-Thanh Vo, Nguyen Thi Le-Na, Hoang Thi Thuy-Duong   +3 more
doaj   +1 more source