Results 1 to 10 of about 468,423 (315)
Keap1-Nrf2 Pathway Regulates ALDH and Contributes to Radioresistance in Breast Cancer Stem Cells
Cells, 2021 Tumor recurrence after radiotherapy due to the presence of breast cancer stem cells (BCSCs) is a clinical challenge, and the mechanism remains unclear.
Dinisha Kamble +3 more
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Highly Polymorphic Materials and Dissolution Behaviour: The Peculiar Case of Rifaximin
Pharmaceutics, 2022 Rifaximin is a locally acting antibiotic practically insoluble in water. It presents several crystal phases characterized by different degrees of hydration. The aim of this work is to investigate the dissolution behaviour of rifaximin α, β, and amorphous
Annalisa Bianchera +4 more
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Cells, 2021 Hypoxia and oxidative stress significantly contribute to breast cancer (BC) progression. Although hypoxia-inducible factor 1α (Hif-1α) is considered a key effector of the cellular response to hypoxia, nuclear factor erythroid 2–related factor 2 (Nrf2), a
Megharani Mahajan, Sandhya Sitasawad
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Understanding Cysteine Chemistry Using Conventional and Serial X-ray Protein Crystallography
Crystals, 2022 Proteins that use cysteine residues for catalysis or regulation are widely distributed and intensively studied, with many biomedically important examples.
Nathan Smith, Mark A. Wilson
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BMC Biology, 2020 Background The mitochondrial intermembrane space (IMS) is home to proteins fulfilling numerous essential cellular processes, particularly in metabolism and mitochondrial function.
Lena Maria Murschall +7 more
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Redox Biochemistry and Chemistry, 2023 Cysteine residues are the most favored targets for oxidation by hypochlorous acid and other reactive halogen species. The end-products of cysteine oxidation are usually considered to be reversibly formed disulfides and the more highly oxidized sulfinic ...
Nicholas J. Magon +3 more
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EGCG-derived polymeric oxidation products enhance insulin sensitivity in db/db mice
Redox Biology, 2022 The present study investigated the influence of epigallocatechin-3-gallate (EGCG) and its autoxidation products on insulin sensitivity in db/db mice.
Ximing Wu +6 more
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Glycols in the Synthesis of Zinc-Anilato Coordination Polymers
Crystals, 2022 We report the synthesis, structural investigation, and thermal behavior for three zinc-based 1D-coordination polymers with 3,6-di-tert-butyl-2,5-dihydroxy-p-benzoquinone, which were synthesized in the presence of different glycols.
Olesya Y. Trofimova +5 more
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Scientific Reports, 2017 Although understanding their chemical composition is vital for accurately predicting the bioactivity of multicomponent drugs, nutraceuticals, and foods, no analytical approach exists to easily predict the bioactivity of multicomponent systems from ...
Yoshinori Fujimura +10 more
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Redox Biology, 2017 The World Health Organization designates lidocaine as an essential medicine in healthcare, greatly increasing the probability of human exposure. Its use has been associated with ROS generation and neurotoxicity. Physiological and metabolomic alterations,
Cory H.T. Boone +4 more
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