Results 41 to 50 of about 394,071 (267)
Frontiers in Cellular and Infection Microbiology, 2023 Chagas disease (CD) is a life-threatening illness caused by the parasite Trypanosoma cruzi (T. cruzi). With around seven million people infected worldwide and over 50,000 deaths per year, CD is a major public health issue in Latin America. The main route
Hellen Daghero +6 more
doaj +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells
eLife, 2023 The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating catabolic conversions of NAD +to NADH and anabolic production of aspartate, a key amino acid for cell proliferation.
Madeleine L Hart +8 more
doaj +1 more source
Cellular Redox Compartments [PDF]
Antioxidants & Redox Signaling, 2018 Although initially considered as harmful, reactive oxygen species (ROS) are now also recognized as important signaling molecules affecting various cellular processes. For example, they contribute to the response to hormones, growth factors, or hypoxia, and defense reactions against mechanical or chemical stress. Therefore, different ROS-generating, ROS-
openaire +3 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Metabolic Control of Redox and Redox Control of Metabolism in Plants [PDF]
Antioxidants & Redox Signaling, 2014 Significance: Reduction-oxidation (Redox) status operates as a major integrator of subcellular and extracellular metabolism and is simultaneously itself regulated by metabolic processes. Redox status not only dominates cellular metabolism due to the prominence of NAD(H)
Geigenberger, P., Fernie, A.
openaire +3 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Redox Pairs in Redox Flow Batteries
Journal of the Korean Electrochemical Society, 2013 레독스 플로우 전지(RFB)는 대형에너지 장치로서 신재생 에너지와 같은 전력발생이 일정하지 못한 상황이나 전력수요가 급증감하여 효율적인 에너지의 운용이 요구될 때 효과적으로 사용할 수있는 전지모델이다. 일부 상용화된 종류도 있지만 다양한 레독스 쌍과 소재가 연구됨에 따라 개선의 여지가 많은 전지이다. 본 총설에서는 전지의 레독스 쌍(redox pair)의 종류들에 대한 설명을 통하여 레독스 플로우 전지의 전반적인 이해를 돕고자 한다. 레독스 쌍의 혼합오염, cross-over, 이온 선택성, 용해도 등의 개선을 통해서 새로운 레독스 플로우 전지의 탄생을 기대할 수있다.
Byunghyun Hwang, Ketack Kim
openaire +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source