Results 51 to 60 of about 677,026 (312)

Structure of the membrane-bound formate hydrogenlyase complex from Escherichia coli

Nature Communications, 2022
New cryo-EM structures of the formate hydrogenlyase complex from the model bacterium E. coli clarify how electrons and protons move through the complex and are combined to make H2 gas.
Ralf Steinhilper, Gabriele Höff, Johann Heider, Bonnie J. Murphy   +3 more
doaj   +1 more source

Overexpression of 2-mercaptoethanesulfonate biosynthesis genes comDE protects methane-producing archaea from oxidative stress

Journal of Bacteriology
Coenzyme M (2-mercaptoethane sulfonate, CoM) is an essential low-molecular-weight thiol in methanogenic archaea (methanogens) that serves as a methyl carrier and as a component of CoM-S-S-CoB heterodisulfide comprising CoM and coenzyme B (7 ...
Alicia M. Salvi, Connor J. Hines, Nicole R. Buan   +2 more
doaj   +1 more source

2,2′-[(1E,1′E)-1,2-Phenylenebis(azanylylidene)bis(methanylylidene)]bis(4-bromophenol)

IUCrData, 2017
In the title compound, C20H14Br2N2O2, there are two intramolecular O—H...N hydrogen bonds forming S(6) ring motifs. The outer benzene rings are inclined to the central benzene ring by 39.09 (11) and 24.31 (11)°, and to one another by 37.12 (11)°.
Souad Dekar, Sabrina Bendia, Kamel Ouari
doaj   +1 more source

Environmental toxicity, redox signaling and lung inflammation:the role of glutathione [PDF]

, 2009
Glutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress.
Saibal K. Biswas, Biswas, Saibal K, Rahman, Irfan, Irfan Rahman   +3 more
core   +1 more source

Charge Transfer Chromophores Derived from 3d-Row Transition Metal Complexes

Molecules, 2022
A series of new charge transfer (CT) chromophores of “α-diimine-MII-catecholate” type (where M is 3d-row transition metals—Cu, Ni, Co) were derived from 4,4′-di-tert-butyl-2,2′-bipyridyl and 3,6-di-tert-butyl-o-benzoquinone (3,6-DTBQ) in accordance with ...
Kira I. Pashanova, Irina V. Ershova, Olesya Yu. Trofimova, Roman V. Rumyantsev, Georgy K. Fukin, Artem S. Bogomyakov, Maxim V. Arsenyev, Alexandr V. Piskunov   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Quantitative analysis of redox proteome reveals oxidation-sensitive protein thiols acting in fundamental processes of developmental hematopoiesis [Elektronisk resurs]

, 2022
Fetal and adult hematopoietic stem and progenitor cells (HSPCs) are characterized by distinct redox homeostasis that may influence their differential cellular behavior in normal and malignant hematopoiesis.
Johansson, E,, Munita, R,, Jassinskaja, M,, Ciesla, M,, Guzzi, N,, Pimkova, K,, Hansson, Jenny,, Lund University., Cao Thi Ngoc, P,, Vajrychova, M,, Bellodi, C,   +10 more
core   +1 more source

Expanding the applications of a bioluminescent mouse infection model of acute African trypanosomiasis

Frontiers in Chemical Biology
IntroductionIn vivo imaging technology based on bioluminescence has contributed to the study of different pathophysiological conditions involving inherited or transmissible diseases.
Diego Benítez, Cecilia Ortíz, Estefania Dibello, Estefania Dibello, Marcelo A. Comini   +4 more
doaj   +1 more source

Cell Culture Characterization of Prooxidative Chain-Transfer Agents as Novel Cytostatic Drugs

Molecules, 2021
Prooxidative therapy is a well-established concept in infectiology and parasitology, in which prooxidative drugs like artemisinin and metronidazole play a pivotal clinical role.
Victoria Heymans, Sascha Kunath, Parvana Hajieva, Bernd Moosmann   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source