Results 11 to 20 of about 677,026 (312)
Keap1-Nrf2 Pathway Regulates ALDH and Contributes to Radioresistance in Breast Cancer Stem Cells
Cells, 2021 Tumor recurrence after radiotherapy due to the presence of breast cancer stem cells (BCSCs) is a clinical challenge, and the mechanism remains unclear.
Dinisha Kamble +3 more
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Highly Polymorphic Materials and Dissolution Behaviour: The Peculiar Case of Rifaximin
Pharmaceutics, 2022 Rifaximin is a locally acting antibiotic practically insoluble in water. It presents several crystal phases characterized by different degrees of hydration. The aim of this work is to investigate the dissolution behaviour of rifaximin α, β, and amorphous
Annalisa Bianchera +4 more
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Antioxidants & Redox Signaling, 2012 Proteins are major targets of reactive oxygen and nitrogen species (ROS/RNS) and numerous post-translational, reversible or irreversible modifications have been characterized, which may lead to a change in the structure and/or function of the oxidized protein.
D. A. Butterfield, I. Dalle-Donne
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Redox controls UPR to control redox [PDF]
Journal of Cell Science, 2014 In many physiological contexts, intracellular reduction–oxidation (redox) conditions and the unfolded protein response (UPR) are important for the control of cell life and death decisions. UPR is triggered by the disruption of endoplasmic reticulum (ER) homeostasis, also known as ER stress. Depending on the duration and severity of the disruption, this
Eletto D +3 more
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Cells, 2021 Hypoxia and oxidative stress significantly contribute to breast cancer (BC) progression. Although hypoxia-inducible factor 1α (Hif-1α) is considered a key effector of the cellular response to hypoxia, nuclear factor erythroid 2–related factor 2 (Nrf2), a
Megharani Mahajan, Sandhya Sitasawad
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Antioxidants & Redox Signaling, 2015 Significance: The redox code is a set of principles that defines the positioning of the nicotinamide adenine dinucleotide (NAD, NADP) and thiol/disulfide and other redox systems as well as the thiol redox proteome in space and time in biological systems.
Jones, Dean P., Sies, Helmut
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Redox Biochemistry and Chemistry, 2023 Cysteine residues are the most favored targets for oxidation by hypochlorous acid and other reactive halogen species. The end-products of cysteine oxidation are usually considered to be reversibly formed disulfides and the more highly oxidized sulfinic ...
Nicholas J. Magon +3 more
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Redox regulation of the insulin signalling pathway [PDF]
, 2021 The peptide hormone insulin is a key regulator of energy metabolism, proliferation and survival. Binding of insulin to its receptor activates the PI3K/AKT signalling pathway, which mediates fundamental cellular responses.
Lennicke, Claudia, Cocheme, Helena
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BMC Biology, 2020 Background The mitochondrial intermembrane space (IMS) is home to proteins fulfilling numerous essential cellular processes, particularly in metabolism and mitochondrial function.
Lena Maria Murschall +7 more
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Understanding Cysteine Chemistry Using Conventional and Serial X-ray Protein Crystallography
Crystals, 2022 Proteins that use cysteine residues for catalysis or regulation are widely distributed and intensively studied, with many biomedically important examples.
Nathan Smith, Mark A. Wilson
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