Results 91 to 100 of about 706,705 (366)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Transmethylation and the redox homeostasis [PDF]

Orvosi Hetilap, 2013
Introduction: Transmethylation modifies configuration and proceeds via formaldehyde. It has a significant role for example in epigenetic regulation. The whole methyl-pool can be evaluated by the measurement of bound formaldehyde. Aim: The bound formaldehyde was measured in wheat, bean, beetroot, cabbage, broiler- and rabbit liver.
Dénes, Kleiner, András, Bersényi, Hedvig, Fébel, Viktor, Hegedűs, Eszter, Mátis, Eva, Sárdi   +5 more
openaire   +2 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Bioinformatics pre-selection of thioredoxin/glutaredoxin target proteins for the construction of cellular redox regulatory network [PDF]

, 2012
Lee H-M. Bioinformatics pre-selection of thioredoxin/glutaredoxin target proteins for the construction of cellular redox regulatory network. Bielefeld: Bielefeld University; 2012.The gradually accumulated knowledge of molecular interaction is assembled ...
Lee, Hang-Mao
core   +1 more source

Redox Regulation Of The Proteasome Via S-glutathionylation [PDF]

, 2015
The proteasome is a multimeric and multicatalytic intracellular protease responsible for the degradation of proteins involved in cell cycle control, various signaling processes, antigen presentation, and control of protein synthesis.
Demasi M., Bicev R.N., Gozzo F., Barros M.H., Leme J.M.M., Netto L.E.S., Hand A., Ohara E., Silva G.M., de Oliveira C.L.P.   +9 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Differences in the Functional Activity and Redox Homeostasis Between the Left and Right Adrenal Gland of Rats Exposed to Chronic Isolation Stress [PDF]

, 2022
Ljubica Gavrilović, Vesna Stojiljković, Snežana Pejić, Vera Spasojević Tišma, Dragan Nikolić, Snežana B. Pajović   +5 more
openalex   +1 more source

Redox-Mediated Stabilization in Zinc Molybdenum Nitrides [PDF]

, 2018
We report on the theoretical prediction and experimental realization of new ternary zinc molybdenum nitride compounds. We used theory to identify previously unknown ternary compounds in the Zn–Mo–N systems, Zn3MoN4 and ZnMoN2, and to analyze their ...
Glenn Teeter (2197876), Stephan Lany, Gerbrand Ceder (380361), Arca, Elisabetta, Wenhao Sun (3201390), John D. Perkins, Brian Gorman (1471699), Glenn Teeter, Holder, Aaron, Wenhao Sun, William Tumas, John D. Perkins (1836259), Bartel, Christopher, Teeter, Glenn, Andriy Zakutayev (1725856), Stephan Lany (1752925), Brian Gorman, Lany, Stephan, John Mangum, John Mangum (1228947), Elisabetta Arca, Sun, Wenhao, Gerbrand Ceder, Aaron Holder (3222642), Aaron Holder, Gorman, Brian, Christopher Bartel (4960819), Perkins, John D, Andriy Zakutayev, Ceder, Gerbrand, William Tumas (1752943), Zakutayev, Andriy, Tumas, William, Christopher Bartel, Elisabetta Arca (4347070), Mangum, John   +35 more
core   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source

MALDI Mass Spectrometry Imaging for Visualizing In Situ Metabolism of Endogenous Metabolites and Dietary Phytochemicals

Metabolites, 2014
Understanding the spatial distribution of bioactive small molecules is indispensable for elucidating their biological or pharmaceutical roles. Mass spectrometry imaging (MSI) enables determination of the distribution of ionizable molecules present in ...
Yoshinori Fujimura, Daisuke Miura
doaj   +1 more source