Results 91 to 100 of about 1,075,897 (355)
Redox Biology, 2022 The increasing abundance of fine particulate matter (PM2.5) in the environment has increased susceptibility to acute exacerbation of COPD (AECOPD). During PM2.5 exposure, excessive reactive oxygen species (ROS) production triggers a redox imbalance ...
Xiaoye Fan +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex
Nature Communications, 2020 Peroxiredoxin 2 (Prx2) was previously shown to transfer H2O2-derived oxidative equivalents to STAT3, generating disulfide-linked dimers and tetramers. Here the authors show that the interaction between Prx2 and STAT3 at the plasma membrane is mediated by
Deepti Talwar +2 more
doaj +1 more source
A quantitative tissue-specific landscape of protein redox regulation during aging
Cell, 2020 Summary Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species (ROS).
Hao-Peng Xiao +19 more
semanticscholar +1 more source
Oxidative eustress: On constant alert for redox homeostasis
Redox Biology, 2021 In the open metabolic system, redox-related signaling requires continuous monitoring and fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a persistent challenge, denoted as oxidative eustress, which operates within a ...
H. Sies
semanticscholar +1 more source
Redox-Switchable Binding Properties of the ATP–Aptamer
, 2019 In this study, we report on a redox-controllable and reversible complete “ON”/“OFF”-switchable aptamer binding to ATP. A series of methylene blue-modified ATP–aptamers was synthesized, revealing improved binding affinities toward ATP as compared to the ...
Guo-Feng Luo (1488661) +9 more
core +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Water deprivation-induced hypoxia and oxidative stress physiology responses in respiratory organs of the Indian stinging fish in near coastal zones [PDF]
PeerJBackground Water deprivation-induced hypoxia stress (WDIHS) has been extensively investigated in numerous fish species due to their adaptation with accessory respiratory organs to respire air but this has not been studied in Indian stinging fish ...
Samar Gourav Pati +4 more
doaj +2 more sources
Nature Communications, 2019 Adhesive hydrogels have gained popularity in biomedical applications, however, traditional adhesive hydrogels often exhibit short-term adhesiveness, poor mechanical properties and lack of antibacterial ability.
Dong-Lin Gan +8 more
semanticscholar +1 more source
Cellular Redox Compartments [PDF]
Antioxidants & Redox Signaling, 2018 Although initially considered as harmful, reactive oxygen species (ROS) are now also recognized as important signaling molecules affecting various cellular processes. For example, they contribute to the response to hormones, growth factors, or hypoxia, and defense reactions against mechanical or chemical stress. Therefore, different ROS-generating, ROS-
openaire +3 more sources