Results 91 to 100 of about 677,026 (312)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source

Redox-Active vs Redox-Innocent: A Comparison of Uranium Complexes Containing Diamine Ligands

, 2018
Uranium complexes (MesDAE)2U­(THF) (1-DAE) and Cp2U­(MesDAE) (2-DAE) (MesDAE = [ArN-CH2CH2-NAr]; Ar = 2,4,6-trimethylphenyl (Mes)), bearing redox-innocent diamide ligands, have been synthesized and characterized for a full comparison with previously ...
Sharon E. Bone (1334667), Stosh A. Kozimor (1615057), Benjamin W. Stein (1334265), Scott A. Pattenaude (1573963), Eric J. Schelter (1317186), Maryline G. Ferrier (2606989), Matthias Zeller (526374), Kimberly C. Mullane (1782907), Phillip E. Fanwick (1360344), Suzanne C. Bart (1360347), Juan S. Lezama Pacheco (1296087)   +10 more
core   +1 more source

Machine Learning‐Supported Analysis for Predicting and Visualizing Nonlinear Relationships Between Material Properties in Electroplated Chromium Layers

Advanced Engineering Materials, EarlyView.
This study applies machine learning regression to predict chromium layer thickness in decorative trivalent chromium electroplating, using 441 experiments from laboratory‐scale (1L) and pilot‐scale (14L) setups. Tree‐based models, particularly CatBoost, outperformed linear regression by capturing nonlinear parameter interactions (R2$R^2$ up to 0.77 ...
Christoph Baumer, Christopher Mai, Luca Eisentraut, Andreas Bund, Ricardo Buettner   +4 more
wiley   +1 more source

Bioinformatics pre-selection of thioredoxin/glutaredoxin target proteins for the construction of cellular redox regulatory network [PDF]

, 2012
Lee H-M. Bioinformatics pre-selection of thioredoxin/glutaredoxin target proteins for the construction of cellular redox regulatory network. Bielefeld: Bielefeld University; 2012.The gradually accumulated knowledge of molecular interaction is assembled ...
Lee, Hang-Mao
core  

MALDI Mass Spectrometry Imaging for Visualizing In Situ Metabolism of Endogenous Metabolites and Dietary Phytochemicals

Metabolites, 2014
Understanding the spatial distribution of bioactive small molecules is indispensable for elucidating their biological or pharmaceutical roles. Mass spectrometry imaging (MSI) enables determination of the distribution of ionizable molecules present in ...
Yoshinori Fujimura, Daisuke Miura
doaj   +1 more source

High‐Resolution Corrosion Fingerprinting of Alloy Libraries via Microdroplet Spectroelectrochemistry

Advanced Engineering Materials, EarlyView.
Ionic‐liquid microdroplet spectroelectrochemistry enables stable, localized electrochemical measurements over extended timescales. By coupling impedance spectroscopy, wetting analysis, finite‐element simulations, and operando Raman spectroscopy, it disentangles geometrical and electrochemical effects, opening new opportunities for rapid corrosion ...
Ekaterina Kurchavova, Oumaïma Gharbi, Mireille Turmine, Vincent Vivier   +3 more
wiley   +1 more source

Redox Control of 20S Proteasome Gating

, 2012
The proteasome is the primary contributor in intracellular proteolysis. Oxidized or unstructured proteins can be degraded via a ubiquitin-and ATP-independent process by the free 20S proteasome (20SPT).
Netto, Luis E. S., Gozzo, Fabio C., Sogayar, Mari C., Santos, Luiz F. A., Demasi, Marcos A. A., Oliveira, Cristiano Luis Pinto de, Silva, Gustavo M., Klitzke, Clecio F., Simoes, Vanessa, Bicev, Renata Naporano, Demasi, Marilene   +10 more
core   +1 more source

Modelling and simulation of all-vanadium redox flow batteries

, 2011
Properties and applications of all-vanadium redox flow batteries are discussed and a two-dimensional model is developed. The model, which is based on a comprehensive description of mass, charge, energy and momentum transport and conservation, is combined
Al-Fetlawi, Hassan Abdul-Zehra Abdul-Yima
core   +1 more source

DPP8/9 processing of human AK2 unmasks an IAP binding motif

EMBO Reports
Adenylate kinase 2 (AK2) is localized in the intermembrane space of mitochondria, where it ensures efficient adenine nucleotide exchange between cytosol and mitochondria. For mitochondrial import, AK2 relies on the MIA40 disulphide relay system.
Kim J Lapacz, Konstantin Weiss, Franziska Mueller, Yuxing Xue, Simon Poepsel, Matthias Weith, Tanja Bange, Jan Riemer   +7 more
doaj   +1 more source