Results 81 to 90 of about 1,001,790 (306)

Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: proof of concept

npj Microgravity
Skeletal muscles overcome terrestrial, gravitational loading by producing tensile forces that produce movement through joint rotation. Conversely, the microgravity of spaceflight reduces tensile loads in working skeletal muscles, causing an adaptive ...
Khaled Y. Kamal, Mariam Atef Othman, Joo-Hyun Kim, John M. Lawler   +3 more
doaj   +1 more source

Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice

BMC Genomics, 2017
Background Nuclear Factor Erythroid-derived 2-like 2 (Nrf2) senses oxidative environments and/or stress and initiates a cytoprotective response through transcriptional activation of antioxidant and detoxification genes.
Justin M. Quiles, Madhusudhanan Narasimhan, Gobinath Shanmugam, Brett Milash, John R. Hoidal, Namakkal S. Rajasekaran   +5 more
doaj   +1 more source

Spectroelectrochemical Elucidation of the Kinetics of Two Closely Spaced Electron Transfers [PDF]

, 2012
The use of spectroelectrochemistry to facilitate the analysis of an EE mechanism was reported in this work. Using a set of spectra as a function of potential, the spectra of all three oxidation states were determined using evolving window factor analysis.
Keesey, Robert L., Ryan, Michael D.
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Redox proteomics of the inflammatory secretome identifies a common set of redoxins and other glutathionylated proteins released in inflammation, influenza virus infection and oxidative stress [PDF]

, 2015
Protein cysteines can form transient disulfides with glutathione (GSH), resulting in the production of glutathionylated proteins, and this process is regarded as a mechanism by which the redox state of the cell can regulate protein function. Most studies
A Erroi, A Kawakami, A Shevchenko, Anna Teresa Palamara, AT Palamara, B Beutler, B Sahaf, BA Beutler, BJ Zheng, C Lind, Christopher Horst Lillig, D Tang, DA Davis, DC Lee, DM Sullivan, E El Eter, Eva-Maria Hanschmann, F Cuello, F Martinon, F Montrichard, FJ Schweigert, FJ Staal, H Huang, H Kono, H Nakamura, H Thor, H Wang, J Cai, JE Meza, JF Andersen, JM McCord, JM Thornton, JP Brennan, JR Godoy, JR Riddell, Juan Sastre, JW Chang, K Tilleman, KR Atkuri, L Coppo, L Mullen, L Nencioni, L Nencioni, L Rossi, LA Herzenberg, Lisa Mullen, Lucas Bowler, Lucia Nencioni, M Bianchi, M Fratelli, M Fratelli, M Valko, Manuela Mengozzi, MC Lee, N Mor-Vaknin, O Takeuchi, P Checconi, P Ghezzi, P Scaffidi, Paola Checconi, Pietro Ghezzi, PJ Kersey, R Bertini, R Geiben-Lynn, R Medzhitov, R Schreck, R Sgarbanti, RC Fahey, Rossella Sgarbanti, S Klein-Scory, S Salzano, Simona Panella, Sonia Salzano, T Akaike, T Hennet, T Laragione, T Laragione, T Oda, T Shichita, TT Phung, Y Tagaya, Y Xie, YM Go   +82 more
core   +4 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Design Principles for High-Capacity Mn-Based Cation-Disordered Rocksalt Cathodes [PDF]

, 2020
Mn-based Li-excess cation-disordered rocksalt (DRX) oxyfluorides are promising candidates for next-generation rechargeable battery cathodes owing to their large energy densities, the earth abundance, and low cost of Mn.
Balasubramanian, M, Cai, Z, Ceder, G, Clément, RJ, Huang, J, Ji, H, Kim, H, Kitchaev, DA, Kwon, DH, Lun, Z, McCloskey, BD, Ouyang, B, Papp, JK, Tian, Y   +13 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

High Reversibility of Lattice Oxygen Redox in Na-ion and Li-ion Batteries Quantified by Direct Bulk Probes of both Anionic and Cationic Redox Reactions [PDF]

, 2018
The reversibility and cyclability of anionic redox in battery electrodes hold the key to its practical employments. Here, through mapping of resonant inelastic X-ray scattering (mRIXS), we have independently quantified the evolving redox states of both ...
Ai, Guo, Chuang, Yi-de, Chueh, William C., Dai, Kehua, Gent, William E., Hussain, Zahid, Li, Qinghao, Li, Zaiyuan, Liu, Gao, Mao, Jing, Pan, Feng, Piper, Louis F. J., Sallis, Shawn, Shen, Zhi-xun, Sun, Chihang, Wu, Jinpeng, Yan, Shishen, Yang, Wanli, Zeng, Rong, Zhuo, Zengqing   +19 more
core   +2 more sources

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source