Results 71 to 80 of about 171,869 (285)

Reduced folate carrier 1 (RFC1) is associated with cleft of the lip only

Brazilian Journal of Medical and Biological Research, 2008
In this report, we have reanalyzed genotyping data in a collection of families from South America based on maternal origin. Genotyping analysis was performed at the Craniofacial Anomalies Research Center at the University of Iowa.
A.R. Vieira, M.E. Cooper, M.L. Marazita, E.E. Castilla, I.M. Orioli   +4 more
doaj  

EFFECT OF SLC19A1 GENE POLYMORPHISM AND HAPLOTYPES ON IDIOPATHIC RECURRENT PREGNANCY LOSS AMONG WOMEN IN DUHOK CITY

Science Journal of University of Zakho
Recurrent pregnancy loss (RPL) affects 1-2% of women of reproductive age and is defined as two or more consecutive losses before 20 weeks of gestation. Idiopathic RPL, which has no known etiology, is increasingly linked to genetic factors, particularly ...
Hozheen Darweesh, Adil Abozaid Eissa
doaj   +1 more source

Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2004
Osteosarcomas are common primary malignant bone tumors that do not respond to conventional low-dose treatments of methotrexate (Mtx), suggesting an intrinsic resistance to this drug. Previous work has shown that cDNAs generated from osteosarcoma mRNA from a fraction of patients contain sequence changes in the reduced folate carrier (RFC), the membrane ...
Flintoff, Wayne F., Sadlish, Heather, Gorlick, Richard, Yang, Rui, Williams, Frederick M.R.   +4 more
openaire   +2 more sources

Metarhizium anisopliae Mitigates the Phytotoxicity of Lead and Nanoplastics on Rice by Modifying Physiological, Transcriptomic, Metabolomic Activities, and Soil Microbiome

Advanced Science, EarlyView.
Metarhizium anisopliae alleviates the phytotoxic effects of polyethylene nanoplastics (NP) and lead (Pb) in rice by decreasing Pb uptake, restoring antioxidant and hormonal equilibrium, and promoting growth. Additionally, the fungus modifies the rhizosphere microbiota, enhancing both contaminant tolerance and plant growth, thereby effectively ...
Jing Peng, Qi Yan, Muhammad Umair Hassan, Muhammad Imran, Fasih Ullah Haider, Jianfeng Liang, Xingmin Wang, Shaukat Ali   +7 more
wiley   +1 more source

Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2001
The reduced folate carrier (RFC1) is a major route for the transport of folates in mammalian cells. The localization of RFC1 in murine tissues was evaluated by immunohistochemical analysis using a polyclonal antibody to the C-terminus of the carrier.
Wang, Yanhua, Zhao, Rongbao, Russell, Robert G, Goldman, I.David   +3 more
openaire   +2 more sources

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy

Drug Delivery, 2020
The combination of chemotherapeutic drug paclitaxel (PTX) and VEGF siRNA could inhibit cancer development with synergistic efficacy. However, efficient and safe delivery systems with high encapsulation efficiency of PTX and a long-time release of drugs ...
Chuanmin Zhang, Yinan Zhao, Enxia Zhang, Meilin Jiang, Defu Zhi, Huiying Chen, Shaohui Cui, Yuhong Zhen, Jingnan Cui, Shubiao Zhang   +9 more
doaj   +1 more source

Multisectoral Convergence of Food, Nutrition and Sanitation Programs for Child Health: Evidence From Country‐Level Programs in India

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This paper underscores the critical role of multisectoral convergence in enhancing child health, particularly in addressing anemia, a micronutrient deficiency linked to both diet and sanitation. We explore how the integration of nationwide food and nutrition programs with sanitation initiatives impacts anemia in Indian children under three ...
Soumya Gupta, Payal Seth, Prabhu Pingali
wiley   +1 more source

The MTR A2756G polymorphism is associated with an increase of plasma homocysteine concentration in Brazilian individuals with Down syndrome

Brazilian Journal of Medical and Biological Research, 2008
Individuals with Down syndrome (DS) present decreased homocysteine (Hcy) concentration, reflecting a functional folate deficiency secondary to overexpression of the cystathionine ß-synthase gene.
J.M Biselli, E.M Goloni-Bertollo, R Haddad, M.N Eberlin, E.C Pavarino-Bertelli   +4 more
doaj  

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source