Results 1 to 10 of about 29,085 (240)

Neuroprotective role of pyrroloquinoline quinone in folate deficiency-induced blood-brain barrier disruption [PDF]

Fluids and Barriers of the CNS
Healthy neurodevelopment requires adequate folates (vitamin B9), which are critical for key biosynthetic and homeostatic processes in the central nervous system (CNS).
Sara Aboulhassane, Vishal Sangha, Md. Tozammel Hoque, Reina Bendayan   +3 more
doaj   +2 more sources

Ischemia-Reperfusion Injury Reduces Kidney Folate Transporter Expression and Plasma Folate Levels

Frontiers in Immunology, 2021
Acute or chronic kidney disease can cause micronutrient deficiency. Patients with end-stage renal disease, kidney transplantation or on dialysis have reduced circulating levels of folate, an essential B vitamin.
Cheng Yang, Cheng Yang, Charith U. B. Wijerathne, Charith U. B. Wijerathne, Guo-wei Tu, Connie W. H. Woo, Yaw L. Siow, Yaw L. Siow, Yaw L. Siow, Susara Madduma Hewage, Susara Madduma Hewage, Kathy K. W. Au-Yeung, Kathy K. W. Au-Yeung, Tongyu Zhu, Tongyu Zhu, Karmin O, Karmin O, Karmin O   +17 more
doaj   +1 more source

Interaction between dolutegravir and folate transporters and receptor in human and rodent placenta

EBioMedicine, 2022
Summary: Background: Due to the critical role of folates in neurodevelopment, it is important to understand potential interactions between anti-HIV drugs used during pregnancy, and folate delivery pathways in the placenta.
Julian C. Gilmore, Md. Tozammel Hoque, Wanying Dai, Haneesha Mohan, Caroline Dunk, Lena Serghides, Reina Bendayan   +6 more
doaj   +1 more source

Reduced folate carrier protein expression in osteosarcoma [PDF]

Cancer, 2003
AbstractBACKGROUNDHigh‐dose methotrexate (MTX) is an important component of current protocols for the treatment of osteosarcoma. Although MTX uptake proceeds primarily through the reduced folate carrier (RFC) protein and efflux occurs via multidrug resistance protein 1 (MRP1), RFC protein expression in osteosarcoma remains unexamined.METHODSRFC and ...
Ilan, Ifergan, Issac, Meller, Josefin, Issakov, Yehuda G, Assaraf   +3 more
openaire   +2 more sources

Luteolin Enhances Choroid Plexus 5-MTHF Brain Transport to Promote Hippocampal Neurogenesis in LOD Rats

Frontiers in Pharmacology, 2022
Folates, provided by food, are commonly used antidepressant synergists in late-onset depression (LOD). However, increased intake of folic acid in the elderly population might lead to the accumulation of unmetabolized folic acid in the systemic ...
Hui-Zhen Li, Kai-Ge Liu, Ning-Xi Zeng, Xiao-Feng Wu, Wen-Jun Lu, Han-Fang Xu, Can Yan, Li-Li Wu   +7 more
doaj   +1 more source

Mutations in the reduced-folate carrier affect protein localization and stability [PDF]

Biochemical Journal, 2000
The reduced-folate-carrier (rfc) gene has been shown to be functionally important for reduced-folate transport in mammalian cells. In the present paper we describe the identification of alterations in both alleles of the rfc gene in a mutant Chinese-hamster ovary cell line deficient in methotrexate transport. One allele of the rfc gene contains a point
H, Sadlish, R C, Murray, F M, Williams, W F, Flintoff   +3 more
openaire   +2 more sources

Reduced folate carrier 1 is present in retinal microvessels and crucial for the inner blood retinal barrier integrity

Fluids and Barriers of the CNS, 2023
Background Reduced folate carrier 1 (RFC1; SLC19a1) is the main responsible transporter for the B9 family of vitamins named folates, which are essential for normal tissue growth and development.
Gokce Gurler, Nevin Belder, Mustafa Caglar Beker, Melike Sever-Bahcekapili, Gokhan Uruk, Ertugrul Kilic, Muge Yemisci   +6 more
doaj   +1 more source

Novel localization of folate transport systems in the murine central nervous system

Fluids and Barriers of the CNS, 2022
Background Folates are a family of B9 vitamins that serve as one-carbon donors critical to biosynthetic processes required for the development and function of the central nervous system (CNS) in mammals.
Vishal Sangha, Md. Tozammel Hoque, Jeffrey T. Henderson, Reina Bendayan   +3 more
doaj   +1 more source

Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter [PDF]

Biochemical Journal, 2004
The hRFC (human reduced folate carrier) is ubiquitously but differentially expressed in human tissues and its levels are regulated by up to seven non-coding regions (A1, A2, A, B, C, D and E) and at least four promoters. For the hRFC-B basal promoter, regulation involves binding of Sp (specificity protein) transcription factors to a critical GC-box. By
Mingjun, Liu, Johnathan R, Whetstine, Scott G, Payton, Yubin, Ge, Robin M, Flatley, Larry H, Matherly   +5 more
openaire   +2 more sources

Efficient delivery of methotrexate to MDA-MB-231 breast cancer cells by a pH-responsive ZnO nanocarrier

Scientific Reports, 2023
Methotrexate (MTX), an efficient chemotherapy medication is used in treating various malignancies. However, the breast cancer cell line MDA-MB-231 has developed resistance to it due to low levels of the MTX transport protein, and reduced folate carrier ...
Jiko Raut, Olivia Sarkar, Tanmoy Das, Santi M. Mandal, Ansuman Chattopadhyay, Prithidipa Sahoo   +5 more
doaj   +1 more source