Results 211 to 220 of about 29,085 (240)

Multifunctional gold nanoparticles: bridging detection, diagnosis, and targeted therapy in cancer. [PDF]

Mol Cancer
Zhuang L, Lian Y, Zhu T.
europepmc   +1 more source

Mesoporous silica nanoparticles--based functional platforms for breast cancer therapy: technological advancements. [PDF]

Front Chem
Du Y, Yang J, Chen S, Fu D.
europepmc   +1 more source

1,3,4-Oxadiazole derivatives: targeting multiple bacterial pathways. [PDF]

RSC Med Chem
Gupta P, Verma S, Narang R, Sharma B, Singh V, Lal S.   +5 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

The Reduced Folate Carrier Gene Is a Novel Selectable Marker for Recombinant Protein Overexpression

Molecular Pharmacology, 2005
Folate cofactors are one-carbon donors essential for the biosynthesis of purines and thymidylate. Mammalian cells are devoid of folate biosynthesis and are therefore folate auxotrophs that take up folate vitamins primarily via the reduced folate carrier (RFC).
Rothem, Lilah, Berman, Bluma, Stark, Michal, Jansen, Gerrit, Assaraf, Yehuda G   +4 more
openaire   +3 more sources

The Reduced Folate/Methotrexate Carrier and a Membrane-Associated Folate Binding Protein as Transport Routes for Novel Antifolates: Structure-Activity Relationships

1993
The role of membrane transport is an important parameter in the biological evaluation of novel antifolates.1–3 In this respect the reduced folate/methotrexate carrier (RFC) is considered to be the major transport route for these compounds in neoplastic cells.4 However, there is accumulating evidence that other transport routes for (anti)folates may be ...
Jansen, G, Westerhof, G R, Schornagel, J H, Jackman, A L, Boyle, F T   +4 more
openaire   +4 more sources

Functional Characterization of Reduced Folate Carrier and Protein-Coupled Folate Transporter for Antifolates Accumulation in Non–Small Cell Lung Cancer Cells

Drug Metabolism and Disposition
Antifolates are important for chemotherapy in non-small cell lung cancer (NSCLC). They mainly rely on reduced folate carrier (RFC) and proton-coupled folate transporter (PCFT) to enter cells. PCFT is supposed to be the dominant transporter of the two in tumors, as it operates optimally at acidic pH and has limited transport activity at physiological pH,
Yuqing Wang, Jun Luo, Mengru Bai, Zhiyuan Ma, Ying Xu, Dan Liu, Huidi Jiang, Shenglin Ma, Shirong Zhang   +8 more
openaire   +2 more sources

Localization of a human reduced folate carrier protein in the mitochondrial as well as the cell membrane of leukemia cells.

Cancer research, 2001
IgG polyclonal antiserum was generated in New Zealand White rabbits immunized with a 16-mer peptide consisting of a specific amino acid sequence at residues corresponding to the sixth to seventh predicted transmembrane domain of the human reduced folate carrier (RFC).
T M, Trippett, S, Garcia, K, Manova, R, Mody, L, Cohen-Gould, W, Flintoff, J R, Bertino   +6 more
openaire   +1 more source