Results 51 to 60 of about 1,116 (113)

Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley   +1 more source

1,2-DCA biodegradation potential of an aquifer assessed in situ and in aerobic and anaerobic microcosms

Environmental Microbiome
Background 1,2-dichloroethane (1,2-DCA) biodegradation can occur through aerobic or anaerobic pathways that can be exploited in bioremediation strategies.
Ilenia Cruciata, Laura Scirè Calabrisotto, Giovanna Carpani, Lucia Poppa, Alfonso Modica, Andrea Pace, Valentina Catania, Paola Quatrini   +7 more
doaj   +1 more source

Metagenomes from Coastal Marine Sediments Give Insights into the Ecological Role and Cellular Features of Loki- and Thorarchaeota

mBio, 2019
The genomes of Asgard Archaea, a novel archaeal proposed superphylum, share an enriched repertoire of eukaryotic signature genes and thus promise to provide insights into early eukaryote evolution.
Lokeshwaran Manoharan, Jessica A. Kozlowski, Robert W. Murdoch, Frank E. Löffler, Filipa L. Sousa, Christa Schleper   +5 more
doaj   +1 more source

Electroenzymatic Cascades for Nitrogen Upgrading: Beyond Ammonia Towards Value‐Added Nitrogen Chemicals

ChemCatChem, Volume 18, Issue 7, 14 April 2026.
This review maps how electroenzymatic cascades that couple nitrogen‐cycle enzymes with C─N bond forming auxilary enzymes, powered by direct electron transfer (DET) or mediated electron transfer (MET), can upgrade N2 and waste nitrogen streams into value‐added amines, amides, amino acids, and other nitrogen‐based chemicals.
Rohit G. Jadhav, Vamshi Krishna Kamaja, Wassim El Housseini, Monica Brachi, Shelley D. Minteer   +4 more
wiley   +1 more source

Small Molecule‐Based Conditional Gene Regulation: Advances and Applications

Chemistry–Methods, Volume 6, Issue 4, April 2026.
The precise, temporal, and reversible control of gene expression using small molecule ligands is crucial for understanding complex cellular functions and is rapidly advancing the field of synthetic biology. Small molecule‐mediated conditional gene regulation has widespread applications, including bio‐manufacturing, cellular reprogramming, gene therapy,
Mohd Afaque Ansari, Riddhima Sharma, Priyanka Swami, Ambadas B. Rode   +3 more
wiley   +1 more source

Insights Into the Biodegradation of Lindane (γ-Hexachlorocyclohexane) Using a Microbial System

Frontiers in Microbiology, 2020
Lindane (γ-hexachlorocyclohexane) is an organochlorine pesticide that has been widely used in agriculture over the last seven decades. The increasing residues of lindane in soil and water environments are toxic to humans and other organisms.
Wenping Zhang, Wenping Zhang, Ziqiu Lin, Ziqiu Lin, Shimei Pang, Shimei Pang, Pankaj Bhatt, Pankaj Bhatt, Shaohua Chen, Shaohua Chen   +9 more
doaj   +1 more source

EnzRetro: Enzymatic Retrosynthetic Planning With Site‐Specific Reaction Edits Based on Sequence Generative Architecture

Exploration, Volume 6, Issue 2, April 2026.
EnzRetro bridges retrosynthesis planning and enzymatic engineering through site‐specific reaction edits. This end‐to‐end framework integrates pathway synthesis and enzyme identification into a unified process, achieving superior accuracy and enabling the efficient reconstruction of diverse biosynthetic pathways.
Yahui Cao, Haoshu Chen, Tao Zhang, Xin Zhao, Bingzhi Li, Xiangrui Zheng   +5 more
wiley   +1 more source

Reductive Debromination of Polybrominated Diphenyl Ethers - Microbes, Processes and Dehalogenases

Frontiers in Microbiology, 2018
Extensive utilization of polybrominated diphenyl ethers (PBDEs) as flame retardants since the 1960s in a variety of commercial products has resulted in ubiquitous environmental distribution of commercial PBDE mixtures.
Siyan Zhao, Matthew J. Rogers, Chang Ding, Jianzhong He   +3 more
doaj   +1 more source

StabLyzeGraph: High‐throughput screening of combinatorial mutations using graph neural networks

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Engineering protein stability is a powerful strategy across biotechnology and medicine, supporting a broad range of applications such as atomic structure determination, discovery of therapeutic molecules, biomanufacturing, diagnostic reagents, industrial biocatalysis, etc.
Muhammad Waqas, Benito Natale, Michele Roggia, Prasenjit Prasad Saha, Mauro Mileni, Sandro Cosconati   +5 more
wiley   +1 more source

SegDesign: A modular framework for controllable protein segment engineering

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Local protein structure engineering, such as targeted remodeling of loops or flexible regions, is critical for mechanistic studies and protein optimization but remains challenging to perform in a controllable and reproducible manner. Despite advances in protein foundation models and generative structure design, most existing methods emphasize ...
Chenjie Feng, Junbo Yin, Chao Zha, Mohammed Saif, Xiaopeng Xu, Xin Gao, Wenjia He   +6 more
wiley   +1 more source