Results 61 to 70 of about 1,120 (114)

StabLyzeGraph: High‐throughput screening of combinatorial mutations using graph neural networks

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Engineering protein stability is a powerful strategy across biotechnology and medicine, supporting a broad range of applications such as atomic structure determination, discovery of therapeutic molecules, biomanufacturing, diagnostic reagents, industrial biocatalysis, etc.
Muhammad Waqas, Benito Natale, Michele Roggia, Prasenjit Prasad Saha, Mauro Mileni, Sandro Cosconati   +5 more
wiley   +1 more source

Whole metagenome sequencing and 16S rRNA gene amplicon analyses reveal the complex microbiome responsible for the success of enhanced in-situ reductive dechlorination (ERD) of a tetrachloroethene-contaminated Superfund site.

PLoS ONE
The North Railroad Avenue Plume (NRAP) Superfund site in New Mexico, USA exemplifies successful chlorinated solvent bioremediation. NRAP was the result of leakage from a dry-cleaning that operated for 37 years.
Rebecca A Reiss, Peter A Guerra, Oleg Makhnin, Matthew Kellom   +3 more
doaj   +1 more source

Chlorine Isotope Effects from Isotope Ratio Mass Spectrometry Suggest Intramolecular C-Cl Bond Competition in Trichloroethene (TCE) Reductive Dehalogenation

Molecules, 2014
Chlorinated ethenes are prevalent groundwater contaminants. To better constrain (bio)chemical reaction mechanisms of reductive dechlorination, the position-specificity of reductive trichloroethene (TCE) dehalogenation was investigated.
Stefan Cretnik, Anat Bernstein, Orfan Shouakar-Stash, Frank Löffler, Martin Elsner   +4 more
doaj   +1 more source

Microbiome dynamics of a polychlorobiphenyl (PCB) historically contaminated marine sediment under conditions promoting reductive dechlorination

Frontiers in Microbiology, 2016
The toxicity of polychlorinated biphenyls (PCB) can be efficiently reduced in contaminated marine sediments through the reductive dechlorination process lead by anaerobic organohalide bacteria.
Bruna Matturro, Carla Ubaldi, Simona Rossetti   +2 more
doaj   +1 more source

Bacterial diversity and reductive dehalogenase redundancy in a 1,2-dichloroethane-degrading bacterial consortium enriched from a contaminated aquifer

Microbial Cell Factories, 2010
Background Bacteria possess a reservoir of metabolic functionalities ready to be exploited for multiple purposes. The use of microorganisms to clean up xenobiotics from polluted ecosystems (e.g.
Wittebolle Lieven, Carpani Giovanna, Corallo Lorenzo, de Ferra Francesca, Balloi Annalisa, Marzorati Massimo, Verstraete Willy, Daffonchio Daniele   +7 more
doaj   +1 more source

Accurate prediction by AlphaFold2 for ligand binding in a reductive dehalogenase and implications for PFAS (per- and polyfluoroalkyl substance) biodegradation. [PDF]

Sci Rep, 2023
Guo HB, Varaljay VA, Kedziora G, Taylor K, Farajollahi S, Lombardo N, Harper E, Hung C, Gross M, Perminov A, Dennis P, Kelley-Loughnane N, Berry R.   +12 more
europepmc   +1 more source

A review in the current developments of genus Dehalococcoides, its consortia and kinetics for bioremediation options of contaminated groundwater

Sustainable Environment Research, 2018
This article reviews the current developments in genus Dehalococcoides as key dechlorinating bacteria in chlorinated ethene contaminated sites. The presence of chlorinated ethenes in environment had been a concern for more than five decades as it ...
Donamel M. Saiyari, Hui-Ping Chuang, Delia B. Senoro, Tsair-Fuh Lin, Liang-Ming Whang, Yi-Ting Chiu, Yi-Hsuan Chen   +6 more
doaj   +1 more source

Spectroscopic and Computational Investigation of the Epoxyqueuosine Reductase QueG Reveals Intriguing Similarities with the Reductive Dehalogenase PceA. [PDF]

Biochemistry, 2022
Greenhalgh ED, Kincannon W, Bandarian V, Brunold TC.   +3 more
europepmc   +1 more source

Genome Sequence, Proteome Profile, and Identification of a Multiprotein Reductive Dehalogenase Complex in <i>Dehalogenimonas alkenigignens</i> Strain BRE15M. [PDF]

J Proteome Res, 2021
Trueba-Santiso A, Wasmund K, Soder-Walz JM, Marco-Urrea E, Adrian L.   +4 more
europepmc   +1 more source

Cofactor binding interactions with reductive dehalogenase shape cobamide utilization in organohalide-respiring bacteria

Communications Biology
Selective utilization of certain cobamides, the vitamin B12-family enzyme cofactors, is a common physiological trait in organohalide respiration, an essential biogeochemical process relevant to global halogen cycling and the bioremediation of chlorinated
Huijuan Jin, Jingjing Wang, Xiuying Li, Yiru Cui, Xiaocui Li, Huan He, Ke Shi, Siqi Huang, Tongyue Zhou, Frank E. Löffler, Jun Yan   +10 more
doaj   +1 more source