Identification of abiotic and biotic reductive dechlorination in a chlorinated ethene plume after thermal source remediation by means of isotopic and molecular biology tools [PDF]
Thermal tetrachloroethene (PCE) remediation by steam injection in a sandy aquifer led to the release of dissolved organic carbon (DOC) from aquifer sediments resulting in more reduced redox conditions, accelerated PCE biodegradation, and changes in ...
Badin, Alice +5 more
core +2 more sources
Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology
Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley +1 more source
This review maps how electroenzymatic cascades that couple nitrogen‐cycle enzymes with C─N bond forming auxilary enzymes, powered by direct electron transfer (DET) or mediated electron transfer (MET), can upgrade N2 and waste nitrogen streams into value‐added amines, amides, amino acids, and other nitrogen‐based chemicals.
Rohit G. Jadhav +4 more
wiley +1 more source
Discovered by genomics: putative reductive dehalogenases with N-terminus transmembrane helixes [PDF]
ABSTRACTAttempts for bioremediation of toxic organohalogens resulted in the identification of organohalide-respiring bacteria harbouring reductive dehalogenases (RDases) enzymes. RDases consist of the catalytic subunit (RdhA, encoded by rdhA) that does not have membrane-integral domains, and a small putative membrane anchor (RdhB, encoded by rdhB) that
openaire +4 more sources
Small Molecule‐Based Conditional Gene Regulation: Advances and Applications
The precise, temporal, and reversible control of gene expression using small molecule ligands is crucial for understanding complex cellular functions and is rapidly advancing the field of synthetic biology. Small molecule‐mediated conditional gene regulation has widespread applications, including bio‐manufacturing, cellular reprogramming, gene therapy,
Mohd Afaque Ansari +3 more
wiley +1 more source
Impact of Ammonium on Syntrophic Organohalide-Respiring and Fermenting Microbial Communities [PDF]
Citation: Delgado, A. G., Fajardo-Williams, D., Kegerreis, K. L., Parameswaran, P., & Krajmalnik-Brown, R. (2016). Impact of Ammonium on Syntrophic Organohalide-Respiring and Fermenting Microbial Communities. Msphere, 1(2), 10.
Anca G. Delgado +5 more
core +2 more sources
Novel reductive dehalogenases from the marine sponge associated bacterium Desulfoluna spongiiphila
Summary Desulfoluna spongiiphila strain AA1 is an organohalide respiring bacterium, isolated from the marine sponge Aplysina aerophoba , that can use brominated and iodinated phenols, in addition to sulfate and thiosulfate as terminal electron acceptors ...
Ahn, Youngbeom +6 more
openaire +3 more sources
Experimental validation of in silico model-predicted isocitrate dehydrogenase and phosphomannose isomerase from Dehalococcoides mccartyi [PDF]
Gene sequences annotated as proteins of unknown or non-specific function and hypothetical proteins account for a large fraction of most genomes. In the strictly anaerobic and organohalide respiring Dehalococcoides mccartyi, this lack of annotation ...
Edwards, Elizabeth A. +6 more
core +2 more sources
EnzRetro bridges retrosynthesis planning and enzymatic engineering through site‐specific reaction edits. This end‐to‐end framework integrates pathway synthesis and enzyme identification into a unified process, achieving superior accuracy and enabling the efficient reconstruction of diverse biosynthetic pathways.
Yahui Cao +5 more
wiley +1 more source
Proteogenomics Reveals Novel Reductive Dehalogenases and Methyltransferases Expressed during Anaerobic Dichloromethane Metabolism [PDF]
Naturally produced and anthropogenically released DCM can reside in anoxic environments, yet little is known about the diversity of organisms, enzymes, and mechanisms involved in carbon-chlorine bond cleavage in the absence of oxygen. A proteogenomic approach identified two RDases and four corrinoid-dependent methyltransferases expressed ...
Sara Kleindienst +10 more
openaire +2 more sources

