Results 101 to 110 of about 5,571,829 (332)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

GENCODE: The reference human genome annotation for The ENCODE Project

Genome Research, 2012
The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and experimental validation.
J. Harrow, A. Frankish, J. Gonzalez, Electra Tapanari, M. Diekhans, F. Kokocinski, Bronwen L. Aken, D. Barrell, A. Zadissa, S. Searle, If H. A. Barnes, A. Bignell, Veronika Boychenko, T. Hunt, M. Kay, Gaurab Mukherjee, J. Rajan, Gloria Despacio-Reyes, Gary I. Saunders, C. Steward, R. Harte, Michael F. Lin, C. Howald, Andrea Tanzer, T. Derrien, Jacqueline Chrast, Nathalie Walters, S. Balasubramanian, Baikang Pei, M. Tress, J. Rodríguez, Iakes Ezkurdia, Jeltje van Baren, M. Brent, D. Haussler, Manolis Kellis, A. Valencia, A. Reymond, M. Gerstein, R. Guigó, T. Hubbard   +40 more
semanticscholar   +1 more source

Comparative genomics of Australian isolates of the wheat stem rust pathogen Puccinia graminis f. sp. tritici reveals extensive polymorphism in candidate effector genes [PDF]

, 2015
The wheat stem rust fungus Puccinia graminis f. sp. tritici (Pgt) is one of the most destructive pathogens of wheat. In this study, a draft genome was built for a founder Australian Pgt isolate of pathotype (pt.) 21-0 (collected in 1954) by next ...
Cuomo, Christina A, Dodds, Peter N, Ellis, Jeffrey G, Garnica, Diana P, Karaoglu, Haydar, Mago, Rohit, Nemri, Adnane, Park, Robert F, Rathjen, John P, Sperschneider, Jana, Upadhyaya, Narayana M, Xu, Bo   +11 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular evidence of hybridization between pig and human Ascaris indicates an interbred species complex infecting humans

eLife, 2020
Human ascariasis is a major neglected tropical disease caused by the nematode Ascaris lumbricoides. We report a 296 megabase (Mb) reference-quality genome comprised of 17,902 protein-coding genes derived from a single, representative Ascaris worm.
Alice Easton, Shenghan Gao, Scott P Lawton, Sasisekhar Bennuru, Asis Khan, Eric Dahlstrom, Rita G Oliveira, Stella Kepha, Stephen F Porcella, Joanne Webster, Roy Anderson, Michael E Grigg, Richard E Davis, Jianbin Wang, Thomas B Nutman   +14 more
doaj   +1 more source

Genome-wide insights into population structure and host specificity of Campylobacter jejuni

Scientific Reports, 2021
The zoonotic pathogen Campylobacter jejuni is among the leading causes of foodborne diseases worldwide. While C. jejuni colonises many wild animals and livestock, persistence mechanisms enabling the bacterium to adapt to host species' guts are not fully ...
Lennard Epping, Birgit Walther, Rosario M. Piro, Marie-Theres Knüver, Charlotte Huber, Andrea Thürmer, Antje Flieger, Angelika Fruth, Nicol Janecko, Lothar H. Wieler, Kerstin Stingl, Torsten Semmler   +11 more
doaj   +1 more source

chroGPS, a global chromatin positioning system for the functional analysis and visualization of the epigenome [PDF]

, 2013
Development of tools to jointly visualize the genome and the epigenome remains a challenge. chroGPS is a computational approach that addresses this question.
Font-Burgada, Joan, Reina, Oscar, Rossell, David, Azorin, Fernando   +3 more
core   +1 more source

Correction: Corrigendum: An ethnically relevant consensus Korean reference genome is a step towards personal reference genomes [PDF]

Nature Communications, 2017
Nature Communications 7: Article number: 13637 (2016): Published 24 November 2016; Updated 9 October 2017. The original version of this Article contained an error in the email address of the corresponding author George Church. The correct email is gchurch@genetics.med.harvard.edu. The error has beencorrected in the HTML and PDF versions of the Article.
Cho, Yun Sung, Kim, Hyunho, Kim, Hak-Min, Jho, Sungwoong, Jun, JeHoon, Lee, Yong Joo, Chae, Kyun Shik, Kim, Chang Geun, Kim, Sangsoo, Eriksson, Anders, Edwards, Jeremy S, Lee, Semin, Kim, Byung Chul, Manica, Andrea, Oh, Tae-Kwang, Church, George M, Bhak, Jong   +16 more
openaire   +3 more sources

The reference genome and organelle genomes of wasabi (Eutrema japoniacum)

Frontiers in Genetics, 2022
Wasabi (Eutrema japonicum) is one of the most famous vegetable crops in the family Brassicaceae. However, a limited genomic resource is available, which hinders genomic breeding and understanding of the genetic basis of vital traits. Here, we generated the genome assembly of wasabi using the hybrid genome assembly strategy, which combined the Nanopore ...
Hexia Liu, Qinghua Qiao, Xiaoxia Ye, Yipeng Guo, Baojian Ye, Qiuyuan Xu, Xingwen Zhou, Xingwen Zhou, Bo Li   +8 more
openaire   +3 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source