Results 101 to 110 of about 48,499 (273)

Synthetic utility and reactivity of N-alkynylazoles [PDF]

, 2015
textThe chemistry of N-alkynylazoles is a newly emerging area of chemistry with particular interest in heterocycle synthesis. Synthetic preparations of this class of molecule have shown an increasing presence in literature, however, the synthetic ...
Gilbreath, Bradford Lynd
core  

Chemoselective or Regioselective?

ChemistryEurope
Over the past two decades, there has been a notable increase in the number of reactions that have been classified as chemoselective and/or regioselective. It is somewhat surprising that neither of these terms is clearly defined, as this often leads to conflicting and confusing designations and makes it challenging to report the results coherently. This
Andrej Kolarovič, Pavol Jakubec
openaire   +2 more sources

One‐Pot Ruthenium‐Catalyzed Synthesis of Benzyl/Allyl‐Halide Substituted (dihydro)naphthalenes via Radical Benzannulation

ChemistryEurope, EarlyView.
A one‐pot protocol to synthesize reactive benzyl‐ and allyl‐halide‐substituted (dihydro)naphthalenes from 2,3‐aryl‐1,3‐butadiene substrates and halogenated alkanes has been developed, using [Cp*RuCl(PPh3)2] as the catalyst. Mechanistic studies revealed an atom transfer radical addition and radical benzannulation sequence, followed by HCl elimination ...
Nicole S. van Leeuwen, David Vesseur, Thijmen Bonhoff, Jeffrey van Laar, Coert E. J. van Lare, Simon Mathew, Sonja Pullen, Joost N. H. Reek, Aalbert Zwijnenburg, Bas de Bruin   +9 more
wiley   +1 more source

Aerobic addition of secondary phosphine oxides to vinyl sulfides: a shortcut to 1-hydroxy-2-(organosulfanyl)ethyl(diorganyl)phosphine oxides

Beilstein Journal of Organic Chemistry, 2015
Secondary phosphine oxides react with vinyl sulfides (both alkyl- and aryl-substituted sulfides) under aerobic and solvent-free conditions (80 °C, air, 7–30 h) to afford 1-hydroxy-2-(organosulfanyl)ethyl(diorganyl)phosphine oxides in 70–93% yields.
Svetlana F. Malysheva, Alexander V. Artem’ev, Nina K. Gusarova, Nataliya A. Belogorlova, Alexander I. Albanov, C. W. Liu, Boris A. Trofimov   +6 more
doaj   +1 more source

Study on the Alkylation Reactions of N(7)-Unsubstituted 1,3-Diazaoxindoles

Molecules, 2017
The chemistry of the 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one (1,3-diazaoxindole) compound family, possessing a drug-like scaffold, is unexplored. In this study, the alkylation reactions of N(7)-unsubstituted 5-isopropyl-1,3-diazaoxindoles bearing ...
Eszter Kókai, Judit Halász, András Dancsó, József Nagy, Gyula Simig, Balázs Volk   +5 more
doaj   +1 more source

Quantitative representation of reactivity, selectivity and site activation concepts in organic chemistry [PDF]

, 2004
Indexación: ScieloReactivity, selectivity and site activation are classical concepts in chemistry which are amenable to quantitative representation, in terms of static global, local and non local density response functions.
Contreras, Renato R., Parra-Mouche, Julia, Pérez, Patricia   +2 more
core  

The Challenging P‐Alkylation of Aromatic Phosphorus Heterocycles and Follow‐Up Reactions

ChemistryEurope, EarlyView.
P‐alkylation of λ3σ2‐phosphinines is hindered by weak nucleophilicity and scarce synthetic access, previously requiring multistep routes or extreme electrophiles. A direct ambient‐condition method is reported using 3,5‐bis(trimethylsilyl)‐phosphinine/B(C6F5)3 with esters or iso(thio)cyanates to generate stable 1‐R‐phosphininium salts.
Samantha Frank, Ádám Horváth, Duy Nguyen, Moritz J. Ernst, Simon Steinhauer, Zoltán Benkő, Christian Müller   +6 more
wiley   +1 more source

Skeletal Editing from Pyridine to Aniline via C‐Insertion and N‐Isomerization

ChemistryEurope, EarlyView.
A concise protocol is presented that converts pyridines into anilines by externalizing the original pyridine nitrogen at either the "ipso" or "ortho" position, which results in para or meta‐primary aniline products. A key carbene‐insertion step precedes nitrogen migration, preserving both ring size and overall structure.
Yun Luo, Jing Dai, Yongchang Wei, Chang Min   +3 more
wiley   +1 more source

Boronate‐Type‐Controlled Regioselective Catalytic [2 + 2 + 2] Cyclotrimerization for Synthesis of Polysubstituted 2‐ and 3‐Borylated Pyridines

ChemistryEurope
Regioselective synthesis is a crucial concept in organic chemistry, enabling the selective formation of different regioisomers from the same type of starting materials.
Eva Bednářová, David Nečas, Rahamdil Usman, Anagha K. Satheeshkumar, Róbert Gyepes, Ivana Císařová, Marko Hapke, Martin Kotora   +7 more
doaj   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source