Results 11 to 20 of about 45,362 (276)

Regioselective Monoborylation of Spirocyclobutenes

Organic Letters, 2021
We present a strategy for the synthesis of spirocyclic cyclobutanes with modulable exit vectors based on the regioselective monoborylation of spirocyclobutenes. Using an inexpensive copper salt and a commercially available bidentate phosphine, a broad variety of borylated spirocycles have been prepared with complete regiocontrol.
Luis Nóvoa, Laura Trulli, Israel Fernández, Alejandro Parra, Mariola Tortosa   +4 more
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Regioselective Oxyselenenylation [PDF]

Chemistry Letters, 1987
Abstract The regioselective oxyselenenylation of terminal olefins or cycloalkenes was achieved via olefin oxymercuration and subsequent radical substitution by selenenylating reagent such as S-benzoyl Se-phenyl selenosulfide, diphenyl diselenide, or phenylselenocyanide.
Takeshi Toru, Yoshio Yamada, Eturô Maekawa, Yoshio Ueno   +3 more
openaire   +1 more source

Highly Regioselective Friedländer Reaction [PDF]

Organic Letters, 2001
[reaction: see text]. A highly regioselective Friedländer reaction is described. By introduction of a phosphonate group at one of the alpha-carbons of a ketone, regioselectivity can be perfectly controlled.
Y, Hsiao, N R, Rivera, N, Yasuda, D L, Hughes, P J, Reider   +4 more
openaire   +2 more sources

Predicting Flavonoid UGT Regioselectivity [PDF]

Advances in Bioinformatics, 2011
Machine learning was applied to a challenging and biologically significant protein classification problem: the prediction of avonoid UGT acceptor regioselectivity from primary sequence. Novel indices characterizing graphical models of residues were proposed and found to be widely distributed among existing amino acid indices and to cluster residues ...
Jackson, Rhydon, Knisley, Debra, McIntosh, Cecilia, Pfeiffer, Phillip   +3 more
openaire   +3 more sources

The Nitrilimine–Alkene Cycloaddition Regioselectivity Rationalized by Density Functional Theory Reactivity Indices

Molecules, 2017
Conventional frontier molecular orbital theory is not able to satisfactorily explain the regioselectivity outcome of the nitrilimine–alkene cycloaddition.
Giorgio Molteni, Alessandro Ponti
doaj   +1 more source

Heavy atom effects in the Paternò–Büchi reaction of pyrimidine derivatives with 4,4’-disubstituted benzophenones

Beilstein Journal of Organic Chemistry, 2011
The regioselectivity and the photochemical efficiency were investigated in the Paternò–Büchi reaction of 1,3-dimethylthymine (DMT) and 1,3-dimethyluracil (DMU) with benzophenone (1b) and some 4,4’-disubstituted derivatives (dimethoxy (1a), difluoro (1c),
Feng-Feng Kong, Jian-Bo Wang, Qin-Hua Song   +2 more
doaj   +1 more source

Deprotometalation-Iodolysis and Direct Iodination of 1-Arylated 7-Azaindoles: Reactivity Studies and Molecule Properties

Molecules, 2021
Five protocols were first compared for the copper-catalyzed C-N bond formation between 7-azaindole and aryl/heteroaryl iodides/bromides. The 1-arylated 7-azaindoles thus obtained were subjected to deprotometalation-iodolysis sequences using lithium 2,2,6,
Mohamed Yacine Ameur Messaoud, Ghenia Bentabed-Ababsa, Ziad Fajloun, Monzer Hamze, Yury S. Halauko, Oleg A. Ivashkevich, Vadim E. Matulis, Thierry Roisnel, Vincent Dorcet, Florence Mongin   +9 more
doaj   +1 more source

Jumping in the Chiral Pool: Asymmetric Hydroaminations with Early Metals

Molecules, 2023
The application of early-metal-based catalysts featuring natural chiral pool motifs, such as amino acids, terpenes and alkaloids, in hydroamination reactions is discussed and compared to those beyond the chiral pool.
Sebastian Notz, Sebastian Scharf, Heinrich Lang   +2 more
doaj   +1 more source

Molecular Basis of C-30 Product Regioselectivity of Legume Oxidases Involved in High-Value Triterpenoid Biosynthesis

Frontiers in Plant Science, 2019
The triterpenes are structurally diverse group of specialized metabolites with important roles in plant defense and human health. Glycyrrhizin, with a carboxyl group at C-30 of its aglycone moiety, is a valuable triterpene glycoside, the production of ...
Much Zaenal Fanani, Ery Odette Fukushima, Ery Odette Fukushima, Satoru Sawai, Satoru Sawai, Satoru Sawai, Satoru Sawai, Jianwei Tang, Masato Ishimori, Hiroshi Sudo, Kiyoshi Ohyama, Kiyoshi Ohyama, Hikaru Seki, Hikaru Seki, Kazuki Saito, Kazuki Saito, Toshiya Muranaka, Toshiya Muranaka   +17 more
doaj   +1 more source

Improving regioselectivity of phenylalanine aminomutase from Taxus chinensis by semi-rational mutagenesis for the biocatalytic amination of cinnamates

Frontiers in Bioengineering and Biotechnology
The occupancy of the binding pocket by the substrate ultimately determines the outcome of enzyme catalysis. Previous engineering and substrate scope of phenylalanine aminomutase from Taxus chinensis (TcPAM) has generated valuable knowledge about the ...
Tao Tang, Miao Wang, Yunyun Zhang, Yijun Chen   +3 more
doaj   +1 more source