Results 11 to 20 of about 4,210,615 (294)
Wellcome Open Research, 2018 Background: Viral oncogenes and mutated proto-oncogenes are potent drivers of cancer malignancy. Downstream of the oncogenic trigger are alterations in protein properties that give rise to cellular transformation and the acquisition of malignant cellular
Tony Ly +6 more
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Cells, 2023 Intracellular trafficking plays a critical role in the functioning of highly polarized cells, such as neurons. Transport of mRNAs, proteins, and other molecules to synaptic terminals maintains contact between neurons and ensures the transmission of nerve
Eugene N. Kozlov +9 more
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Functional Characteristics of Gene Expression Motifs with Single and Dual Strategies of Regulation [PDF]
Biomed. Phys. Eng. Express, 2 , 025009(2016), 2016 Transcriptional regulation by transcription factors and post-transcriptional regulation by microRNAs constitute two major modes of regulation of gene expression. While gene expression motifs incorporating solely transcriptional regulation are well investigated, the dynamics of motifs with dual strategies of regulation, i.e., both transcriptional and ...
arxiv +1 more source
MicroRNAs preferentially target the genes with high transcriptional regulation complexity [PDF]
Biochem Biophys Res Commun., 352:733-738, 2007, 2006 Over the past few years, microRNAs (miRNAs) have emerged as a new prominent class of gene regulatory factors that negatively regulate expression of approximately one-third of the genes in animal genomes at post-transcriptional level. However, it is still unclear why some genes are regulated by miRNAs but others are not, i.e.
arxiv +1 more source
SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
Nature Communications, 2018 The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ...
Shuai Wu +11 more
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Open Biology, 2021 Treslin/Ticrr is required for the initiation of DNA replication and binds to MTBP (Mdm2 Binding Protein). Here, we show that in Xenopus egg extract, MTBP forms an elongated tetramer with Treslin containing two molecules of each protein.
Ilaria Volpi +3 more
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The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element
Genome Biology, 2017 Background It is now obvious that the majority of cellular transcripts do not code for proteins, and a significant subset of them are long non-coding RNAs (lncRNAs).
Oskar Marín-Béjar +12 more
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A lncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions
Nature Communications, 2020 SWI/SNF complexes regulate chromatin architecture and gene expression. Here the authors report the RNA interactome of SMARCB1-containing SWI/SNF complexes, showing the function of SMARCB1-interacting long noncoding RNA SWINGN in transcriptional ...
Elena Grossi +8 more
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Cells, 2020 Chromosomes are organized into 3D structures that are important for the regulation of gene expression and differentiation. Important role in formation of inter-chromosome contacts play rDNA clusters that make up nucleoli. In the course of differentiation,
Nickolai A. Tchurikov +7 more
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Regulation-incorporated Gene Expression Network-based Heterogeneity Analysis [PDF]
arXiv, 2023 Gene expression-based heterogeneity analysis has been extensively conducted. In recent studies, it has been shown that network-based analysis, which takes a system perspective and accommodates the interconnections among genes, can be more informative than that based on simpler statistics. Gene expressions are highly regulated. Incorporating regulations
arxiv