Results 11 to 20 of about 2,975,952 (304)

Genome-wide co-expression analysis in multiple tissues [PDF]

, 2008
Expression quantitative trait loci (eQTLs) represent genetic control points of gene expression, and can be categorized as cis- and trans-acting, reflecting local and distant regulation of gene expression respectively.
Aitman, T.J., Cook, S.A., Dickens, N.J., Grieve, I.C., Hubner, N., Kren, V., Mangion, J., Petretto, E., Pravenec, M.   +8 more
core   +9 more sources

Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

Nature Communications, 2020
ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of ...
Wenqing Ren, Nicole Medeiros, Robert Warneford-Thomson, Phillip Wulfridge, Qingqing Yan, Joyce Bian, Simone Sidoli, Benjamin A. Garcia, Emmanuel Skordalakes, Eric Joyce, Roberto Bonasio, Kavitha Sarma   +11 more
doaj   +1 more source

Brassinosteroid-Regulated Gene Expression [PDF]

Plant Physiology, 2002
Abstract Major brassinosteroid (BR) effects such as BR-induced growth are mediated through genomic pathways because RNA synthesis inhibitors and protein synthesis inhibitors interfere with these processes. A limited number of BR-regulated genes have been identified hitherto. The majority of genes (such as BRU1, CycD3,Lin6, OPR3, and TRIP-
Altmann, Thomas, Müssig, Carsten, Fischer, Sabine   +2 more
openaire   +3 more sources

Opposing Roles of Wild-type and Mutant p53 in the Process of Epithelial to Mesenchymal Transition

Frontiers in Molecular Biosciences, 2022
The central role of an aberrantly activated EMT program in defining the critical features of aggressive carcinomas is well documented and includes cell plasticity, metastatic dissemination, drug resistance, and cancer stem cell-like phenotypes.
Oleg Semenov, Alexandra Daks, Olga Fedorova, Oleg Shuvalov, Nickolai A. Barlev, Nickolai A. Barlev, Nickolai A. Barlev   +6 more
doaj   +1 more source

Proteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells [version 1; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: Viral oncogenes and mutated proto-oncogenes are potent drivers of cancer malignancy. Downstream of the oncogenic trigger are alterations in protein properties that give rise to cellular transformation and the acquisition of malignant cellular
Tony Ly, Aki Endo, Alejandro Brenes, Marek Gierlinski, Vackar Afzal, Andrea Pawellek, Angus I. Lamond   +6 more
doaj   +1 more source

Regulation of gene expression by insulin [PDF]

Biochemical Journal, 1991
While insulin has long been known to modulate intracellular metabolism by altering the activity or intracellular location of various enzymes, it is only in the past 10 years that the regulation of gene expression by insulin has been recognized as a major action of this hormone. This review principally focuses on the regulation of gene transcription by
Daryl K. Granner, Richard M. O'Brien
openaire   +5 more sources

Metabolic regulation of gene expression by histone lactylation

Nature, 2019
The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells.
Di Zhang, Zhanyun Tang, He Huang, He Huang, Guolin Zhou, Chang Cui, Yejing Weng, Wenchao Liu, Sunjoo Kim, Sangkyu Lee, Mathew Perez-Neut, Jun Ding, Daniel M. Czyż, Rong Hu, Z. Ye, Maomao He, Y. G. Zheng, H. Shuman, Lunzhi Dai, Lunzhi Dai, B. Ren, R. Roeder, L. Becker, Yingming Zhao   +23 more
semanticscholar   +1 more source

TNF-alpha inhibition ameliorates HDV-induced liver damage in a mouse model of acute severe infection

JHEP Reports, 2020
Background & Aims: HDV infection induces the most severe form of human viral hepatitis. However, the specific reasons for the severity of the disease remain unknown.
Carla Usai, Sheila Maestro, Gracian Camps, Cristina Olague, Lester Suárez-Amaran, Africa Vales, Tomas Aragon, Mirja Hommel, Rafael Aldabe, Gloria Gonzalez-Aseguinolaza   +9 more
doaj   +1 more source

The context of gene expression regulation [PDF]

F1000 Biology Reports, 2012
Recent advances in sequencing technologies have uncovered a world of RNAs that do not code for proteins, known as non-protein coding RNAs, that play important roles in gene regulation. Along with histone modifications and transcription factors, non-coding RNA is part of a layer of transcriptional control on top of the DNA code. This layer of components
Gibcus, Johan H, Dekker, Job
openaire   +4 more sources

3′UTR of mRNA Encoding CPEB Protein Orb2 Plays an Essential Role in Intracellular Transport in Neurons

Cells, 2023
Intracellular trafficking plays a critical role in the functioning of highly polarized cells, such as neurons. Transport of mRNAs, proteins, and other molecules to synaptic terminals maintains contact between neurons and ensures the transmission of nerve
Eugene N. Kozlov, Roman V. Deev, Elena V. Tokmatcheva, Anna Tvorogova, Zaur M. Kachaev, Rudolf A. Gilmutdinov, Mariya Zhukova, Elena V. Savvateeva-Popova, Paul Schedl, Yulii V. Shidlovskii   +9 more
doaj   +1 more source