Results 21 to 30 of about 4,210,615 (294)
Scientific Reports, 2017 Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C.
Sarah-Lena Offenburger +4 more
doaj +1 more source
Intrinsic noise of microRNA-regulated genes and the ceRNA hypothesis [PDF]
PLoS ONE 8(8): e72676 (2013), 2012 MicroRNAs are small noncoding RNAs that regulate genes post-transciptionally by binding and degrading target eukaryotic mRNAs. We use a quantitative model to study gene regulation by inhibitory microRNAs and compare it to gene regulation by prokaryotic small non-coding RNAs (sRNAs).
arxiv +1 more source
Bio-Protocol, 2021 Polysome profile analysis is a popular method for separating polysomes and ribosomal subunits and is typically achieved using a sucrose density gradient (SDG).
Harunori Yoshikawa +4 more
doaj +1 more source
ARID1A promotes genomic stability through protecting telomere cohesion
Nature Communications, 2019 Cells with ARID1A mutations exhibit mitotic defects, yet show surprisingly low levels of copy number defects. Here, Zhao et al. resolve this issue by showing that ARID1A loss causes defects in telomere cohesion, which selects against gross alterations in
Bo Zhao +16 more
doaj +1 more source
Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
Molecular Medicine, 2020 The hereditary aspect of obesity is a major focus of modern medical genetics. The genetic background is known to determine a higher-than-average prevalence of obesity in certain regions, like Oceania.
Anna E. Pravednikova +7 more
doaj +1 more source
BCL7A is silenced by hypermethylation to promote acute myeloid leukemia
Biomarker Research, 2023 Background Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorly understood.
Juan Rodrigo Patiño-Mercau +8 more
doaj +1 more source
Master regulators as order parameters of gene expression states [PDF]
Phys. Rev. E 103, 012409 (2021), 2020 Cell type-specific gene expression patterns are represented as memory states of a Hopfield neural network model. It is shown that order parameters of this model can be interpreted as concentrations of master transcription regulators that form concurrent positive feedback loops with a large number of downstream regulated genes.
arxiv +1 more source
Cell Reports, 2017 Dbf4-dependent kinases (DDKs) are required for the initiation of DNA replication, their essential targets being the MCM2-7 proteins. We show that, in Xenopus laevis egg extracts and human cells, hyper-phosphorylation of DNA-bound Mcm4, but not ...
Robert C. Alver +3 more
doaj +1 more source
Investigation of the Basic Steps in the Chromosome Conformation Capture Procedure
Frontiers in Genetics, 2021 A constellation of chromosome conformation capture methods (С-methods) are an important tool for biochemical analysis of the spatial interactions between DNA regions that are separated in the primary sequence.
Oleg V. Bylino +5 more
doaj +1 more source
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source