Results 31 to 40 of about 1,600,466 (167)
Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases
Molecular Medicine, 2020 The hereditary aspect of obesity is a major focus of modern medical genetics. The genetic background is known to determine a higher-than-average prevalence of obesity in certain regions, like Oceania.
Anna E. Pravednikova +7 more
doaj +1 more source
Regulation of expression of the erythropoietin gene
Current Opinion in Hematology, 1998 Erythropoietin, a hormone produced in the adult kidney, controls erythrocyte production. In response to ischemic or hypoxic hypoxia, the level of expression of the gene increases markedly. We have a limited understanding of the factors governing the tissue specificity of erythropoietin gene expression but considerable progress has been made toward ...
Maxwell, P, Ratcliffe, P
openaire +3 more sources
BCL7A is silenced by hypermethylation to promote acute myeloid leukemia
Biomarker Research, 2023 Background Recent massive sequencing studies have revealed that SWI/SNF complexes are among the most frequently altered functional entities in solid tumors. However, the role of SWI/SNF in acute myeloid leukemia is poorly understood.
Juan Rodrigo Patiño-Mercau +8 more
doaj +1 more source
Cell Reports, 2017 Dbf4-dependent kinases (DDKs) are required for the initiation of DNA replication, their essential targets being the MCM2-7 proteins. We show that, in Xenopus laevis egg extracts and human cells, hyper-phosphorylation of DNA-bound Mcm4, but not ...
Robert C. Alver +3 more
doaj +1 more source
Clinical & Translational Immunology, 2022 Objective Pre‐existing neutralising antibodies (NAbs) to adeno‐associated viruses (AAVs) remain an impediment for systemically administered AAV‐mediated gene therapy treatment in many patients, and various strategies are under investigation to overcome ...
Irene Ros‐Gañán +11 more
doaj +1 more source
Investigation of the Basic Steps in the Chromosome Conformation Capture Procedure
Frontiers in Genetics, 2021 A constellation of chromosome conformation capture methods (С-methods) are an important tool for biochemical analysis of the spatial interactions between DNA regions that are separated in the primary sequence.
Oleg V. Bylino +5 more
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ISR8/IRF1-AS1 Is Relevant for IFNα and NF-κB Responses
Frontiers in Immunology, 2022 The study of the interferon (IFN) α-induced cell transcriptome has shown altered expression of several long non-coding RNAs (lncRNAs). ISR8/IRF1-AS1 (IFN stimulated RNA 8), located close to IFN regulatory factor 1 (IRF1) coding gene, transcribes a lncRNA
Marina Barriocanal +8 more
doaj +1 more source
CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
Nature Communications, 2018 CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor ...
Sergey Karakashev +14 more
doaj +1 more source
Consequences of early life stress on genomic landscape of H3K4me3 in prefrontal cortex of adult mice
BMC Genomics, 2018 Background Maternal separation models in rodents are widely used to establish molecular mechanisms underlying prolonged effects of early life adversity on neurobiological and behavioral outcomes in adulthood.
Nikita I. Ershov +5 more
doaj +1 more source
Long-Term Memory Formation in Drosophila Depends on the 3′UTR of CPEB Gene orb2
Cells, 2023 Activation of local translation in neurites in response to stimulation is an important step in the formation of long-term memory (LTM). CPEB proteins are a family of translation factors involved in LTM formation. The Drosophila CPEB protein Orb2 plays an
Eugene N. Kozlov +10 more
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