Results 1 to 10 of about 5,375,401 (399)

Massively parallel characterization of transcriptional regulatory elements. [PDF]

Nature
The human genome contains millions of candidate cis-regulatory elements (cCREs) with cell-type-specific activities that shape both health and many disease states1.
Agarwal V, Inoue F, Schubach M, Penzar D, Martin BK, Dash PM, Keukeleire P, Zhang Z, Sohota A, Zhao J, Georgakopoulos-Soares I, Noble WS, Yardımcı GG, Kulakovskiy IV, Kircher M, Shendure J, Ahituv N.   +16 more
europepmc   +2 more sources

Accurate prediction of gene feedback circuit behavior from component properties [PDF]

Molecular Systems Biology, 2007
A basic assumption underlying synthetic biology is that analysis of genetic circuit elements, such as regulatory proteins and promoters, can be used to understand and predict the behavior of circuits containing those elements. To test this assumption, we
Nitzan Rosenfeld, Jonathan W Young, Uri Alon, Peter S Swain, Michael B Elowitz   +4 more
doaj   +4 more sources

Determination of the transcription unit landscape and associated regulatory elements in Methylosinus sporium 5 [PDF]

Microbiology Spectrum
Methanotrophic bacteria show significant promise for methane bioconversion. Despite their ecological and biotechnological importance, the understanding of their transcriptional regulation and genetic regulatory elements remains limited.
Jiyun Bae, Dong-Uk Song, Hyewon Lee, Seung-Goo Lee, Byung-Kwan Cho   +4 more
doaj   +2 more sources

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances. [PDF]

Nat Genet
Phan MHQ, Zehnder T, Puntieri F, Magg A, Majchrzycka B, Antonović M, Wieler H, Lo BW, Baranasic D, Lenhard B, Müller F, Vingron M, Ibrahim DM.   +12 more
europepmc   +3 more sources

Investigation of regulatory elements related to superoxide dismutase enzyme genes in wheat [PDF]

بیوتکنولوژی و بیوشیمی غلات, 2023
Introduction: Wheat, like other plants, uses antioxidant enzymes to deal with the high production of free oxygen radicals. Antioxidant enzymes are proteins or polypeptides that are activated in cooperation with cellular substances or mineral elements and
Armin Saed-Moucheshi, Hooshmand Safari
doaj   +1 more source

Function and Regulation of Nuclear DNA Sensors During Viral Infection and Tumorigenesis

Frontiers in Immunology, 2021
IFI16, hnRNPA2B1, and nuclear cGAS are nuclear-located DNA sensors that play important roles in initiating host antiviral immunity and modulating tumorigenesis.
Fan Zhang, Fan Zhang, Yi Yuan, Yi Yuan, Yi Yuan, Feng Ma, Feng Ma   +6 more
doaj   +1 more source

Identification of Genes and inducible regulatory elements in response to heat and cold stresses in barley (Hordeum vulgare L.) [PDF]

بیوتکنولوژی و بیوشیمی غلات, 2022
Introduction: Barley (Hordeum vulgare), a member of the Poaceae family, is an important cereal grown in temperate climates worldwide. It was one of the first cultivated grains, especially in Eurasia 10,000 years ago. Globally, 70% of barley production is
Danial Kahrizi
doaj   +1 more source

An atlas of regulatory elements in chicken: A resource for chicken genetics and genomics

Science Advances, 2023
A comprehensive characterization of regulatory elements in the chicken genome across tissues will have substantial impacts on both fundamental and applied research.
Z. Pan, Ying Wang, Mingshan Wang, Yuzhe Wang, Xiaoning Zhu, Shenwen V. Gu, Conghao Zhong, Liqi An, Mingzhu Shan, Joana Damas, M. Halstead, D. Guan, N. Trakooljul, K. Wimmers, Y. Bi, Shang Wu, M. Delany, Xuechen Bai, Hans H. Cheng, Congjiao Sun, Ning Yang, Xiaoxiang Hu, H. Lewin, L. Fang, Huaijun Zhou   +24 more
semanticscholar   +1 more source

Parallel genetics of regulatory sequences using scalable genome editing in vivo

Cell Reports, 2021
Summary: How regulatory sequences control gene expression is fundamental for explaining phenotypes in health and disease. Regulatory elements must ultimately be understood within their genomic environment and development- or tissue-specific contexts ...
Jonathan J. Froehlich, Bora Uyar, Margareta Herzog, Kathrin Theil, Petar Glažar, Altuna Akalin, Nikolaus Rajewsky   +6 more
doaj   +1 more source

Rapid nuclear deadenylation of mammalian messenger RNA

iScience, 2023
Summary: Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm.
Jonathan Alles, Ivano Legnini, Maddalena Pacelli, Nikolaus Rajewsky   +3 more
doaj   +1 more source