Results 101 to 110 of about 5,375,401 (399)

Genetic Variation in Human Gene Regulatory Factors Uncovers Regulatory Roles in Local Adaptation and Disease [PDF]

, 2019
Differences in gene regulation have been suggested to play essential roles in the evolution of phenotypic changes. Although DNA changes in cis-regulatory elements affect only the regulation of its corresponding gene, variations in gene regulatory factors
Nowick, Katja, Perdomo-Sabogal, Álvaro
core   +1 more source

A unified architecture of transcriptional regulatory elements [PDF]

Trends in Genetics, 2015
AbstractGene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications.
Andersson, Robin, Sandelin, Albin, Danko, Charles G   +2 more
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

ETS1 Suppresses Tumorigenesis of Human Breast Cancer via Trans-Activation of Canonical Tumor Suppressor Genes

Frontiers in Oncology, 2020
ETS1 has shown dichotomous roles as an oncogene and a tumor suppressor gene in diverse cancers, but its functionality in breast cancer tumorigenesis still remains unclear.
Gi-Cheon Kim, Gi-Cheon Kim, Choong-Gu Lee, Ravi Verma, Dipayan Rudra, Taemook Kim, Keunsoo Kang, Jong Hee Nam, Young Kim, Sin-Hyeog Im, Sin-Hyeog Im, Ho-Keun Kwon, Ho-Keun Kwon, Ho-Keun Kwon   +13 more
doaj   +1 more source

Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. [PDF]

, 2010
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes.
Alekseyenko, Artyom A, Bishop, Eric P, Canfield, Theresa K, Elgin, Sarah CR, Ernst, Jason, Gorchakov, Andrey A, Gu, Tingting, Jung, Youngsook L, Karpen, Gary H, Kellis, Manolis, Kharchenko, Peter V, Kuroda, Mitzi I, Larschan, Erica, Linder-Basso, Daniela, Luquette, Lovelace J, MacAlpine, David M, Minoda, Aki, Park, Peter J, Park, Richard W, Pirrotta, Vincenzo, Plachetka, Annette, Riddle, Nicole C, Sabo, Peter J, Sandstrom, Richard, Schwartz, Yuri B, Shanower, Gregory, Stamatoyannopoulos, John A, Thurman, Robert E, Tolstorukov, Michael Y, Xi, Ruibin   +29 more
core   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Protocol for siRNA-mediated U1 snRNA knockdown using fluorinated α-helical polypeptide in vitro and in vivo

STAR Protocols
Summary: Here, we present a protocol for small interfering RNA (siRNA)-mediated U1 small nuclear RNA (snRNA) knockdown using fluorinated α-helical polypeptide in macrophages and mouse lungs, providing a dependable approach to silence U1 snRNA in vitro ...
Fan Zhang, Chenglong Ge, Zigang Qiao, Yu Han, Lichen Yin, Feng Ma   +5 more
doaj   +1 more source

Design principles for riboswitch function [PDF]

, 2009
Scientific and technological advances that enable the tuning of integrated regulatory components to match network and system requirements are critical to reliably control the function of biological systems. RNA provides a promising building block for the
A Belle, A Levchenko, A Zaslaver, Adam P. Arkin, B Suess, B Suess, CA Voigt, Chase L. Beisel, Christina D. Smolke, CI An, CL Beisel, DH Mathews, DJ Klein, DM Crothers, DW Selinger, E Dekel, FJ Isaacs, FJ Isaacs, GJ Leclerc, GM Emilsson, GM Suel, GR Zimmermann, HM Al-Hashimi, J Tomsic, JA Bernstein, JA Collins, JE Barrick, JF Lemay, JK Wickiser, JK Wickiser, K Lang, LJ Su, LV Danilova, M Acar, M Parisien, MN Win, MN Win, MR Bennett, MT Cheah, MT Woodside, N Hao, O Kensch, P Corish, PP Zarrinkar, PT Li, R Narsai, R Rieder, RD Jenison, RR Breaker, S Topp, S Topp, SA Lynch, SE Osborne, SK Desai, T Pan, TH Lee, TS Bayer, WC Winkler, WC Winkler, WJ Greenleaf, X Zhang, X Zhuang, Y Yokobayashi   +62 more
core   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Discovery of Zharp1-163 as a dual inhibitor of ferroptosis and necroptosis for the treatment of inflammatory disorders and kidney injury

Cell Death Discovery
Dysregulation of cell death plays a critical role in the onset and progression of numerous human diseases. Distinct forms of regulated cell death, such as necroptosis and ferroptosis, have been implicated in the pathogenesis of various conditions ...
Yuting Ji, Shujing Du, Jingjing Li, Haikuo Ma, Xinhui Wang, Yongjin Hao, Zhanhui Li, Haohao Lu, Hao Liu, Chengkui Yang, Xiaohu Zhang, Sudan He   +11 more
doaj   +1 more source