Results 101 to 110 of about 5,141,166 (402)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

A Highly Conserved Circular RNA Is Required to Keep Neural Cells in a Progenitor State in the Mammalian Brain

Cell Reports, 2020
Summary: circSLC45A4 is the main RNA splice isoform produced from its genetic locus and one of the highest expressed circRNAs in the developing human frontal cortex.
Christin Suenkel, Daniel Cavalli, Simone Massalini, Federico Calegari, Nikolaus Rajewsky   +4 more
doaj  

Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche

Cell Reports, 2016
In vertebrate embryos, anterior tissues are generated early, followed by the other axial structures that emerge sequentially from a posterior growth zone. The genetic network driving posterior axial elongation in mice, and its disturbance in mutants with
Shilu Amin, Roel Neijts, Salvatore Simmini, Carina van Rooijen, Sander C. Tan, Lennart Kester, Alexander van Oudenaarden, Menno P. Creyghton, Jacqueline Deschamps   +8 more
doaj   +1 more source

Fast and Accurate Clustering of Single Cell Epigenomes Reveals Cis-Regulatory Elements in Rare Cell Types

, 2019
Mammalian tissues are composed of highly specialized cell types defined by distinct gene expression patterns. Identification of cis-regulatory elements responsible for cell-type specific gene expression is essential for understanding the origin of the ...
Rongxin Fang, Sebastian Preissl, Y. Li, Xiaomeng Hou, J. Lucero, Xinxin Wang, Amir Motamedi, A. Shiau, Xinzhu Zhou, Fangming Xie, E. Mukamel, Kai Zhang, Yanxiao Zhang, M. Behrens, J. Ecker, B. Ren   +15 more
semanticscholar   +1 more source

CRISPR–Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

Nature Biotechnology, 2017
Large genome-mapping consortia and thousands of genome-wide association studies have identified non-protein-coding elements in the genome as having a central role in various biological processes.
Tyler S. Klann, Joshua B. Black, M. Chellappan, Alexias Safi, Lingyun Song, Isaac B. Hilton, G. Crawford, Timothy E. Reddy, C. Gersbach   +8 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Genetic Variation in Human Gene Regulatory Factors Uncovers Regulatory Roles in Local Adaptation and Disease [PDF]

, 2019
Differences in gene regulation have been suggested to play essential roles in the evolution of phenotypic changes. Although DNA changes in cis-regulatory elements affect only the regulation of its corresponding gene, variations in gene regulatory factors
Nowick, Katja, Perdomo-Sabogal, Álvaro
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Handshakes and Fights: The Regulatory Interplay of RNA-Binding Proteins

Frontiers in Molecular Biosciences, 2017
What drives the flow of signals controlling the outcome of post-transcriptional regulation of gene expression? This regulatory layer, presiding to processes ranging from splicing to mRNA stability and localization, is a key determinant of protein levels ...
Erik Dassi
doaj   +1 more source

Plant cis-acting regulatory DNA elements (PLACE) database: 1999

Nucleic Acids Res., 1999
PLACE (http://www.dna.affrc.go.jp/htdocs/PLACE/) is a database of nucleotide sequence motifs found in plant cis-acting regulatory DNA elements. Motifs were extracted from previously published reports on genes in vascular plants. In addition to the motifs
K. Higo, Y. Ugawa, M. Iwamoto, Tomoko Korenaga   +3 more
semanticscholar   +1 more source