Results 11 to 20 of about 5,141,166 (402)
Information capacity of genetic regulatory elements [PDF]
Physical Review E, 2008 17 pages, 9 ...
Gašper Tkačik +2 more
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Regulatory Elements for Gene Therapy of Epilepsy [PDF]
CellsThe problem of drug resistance in epilepsy means that in many cases, a surgical treatment may be advised. But this is only possible if there is an epileptic focus, and resective brain surgery may have adverse side effects. One of the promising alternatives is gene therapy, which allows the targeted expression of therapeutic genes in different brain ...
Ekaterina Chesnokova +3 more
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Accurate prediction of gene feedback circuit behavior from component properties [PDF]
Molecular Systems Biology, 2007 A basic assumption underlying synthetic biology is that analysis of genetic circuit elements, such as regulatory proteins and promoters, can be used to understand and predict the behavior of circuits containing those elements. To test this assumption, we
Nitzan Rosenfeld +4 more
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Regulatory transposable elements in the encyclopedia of DNA elements
Nature Communications, 2023 Transposable elements (TEs) comprise ~50% of our genome, but knowledge of how TEs affect genome evolution remains incomplete. Leveraging ENCODE4 data, we provide the most comprehensive study to date of TE contributions to the regulatory genome.
Alan Y. Du +4 more
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A Set of Proximal Regulatory Elements Contribute to the Transcriptional Activity of the Human Lipoprotein Lipase Promoter [PDF]
Current Issues in Molecular BiologyLipoprotein lipase (LPL) is a multifunctional protein that catalyzes the hydrolysis of plasma triglycerides, releasing free fatty acids, which play critical roles in the metabolism and transport of lipids.
Nasmah K. Bastaki +4 more
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Sequence determinants of human gene regulatory elements
Nature Genetics, 2021 DNA can determine where and when genes are expressed, but the full set of sequence determinants that control gene expression is unknown. Here, we measured the transcriptional activity of DNA sequences that represent an ~100 times larger sequence space ...
Biswajyoti Sahu +12 more
semanticscholar +1 more source
Regulatory elements of the erythropoietin gene [PDF]
Blood, 1991 Abstract Because the human hepatoma cell line Hep3B produces erythropoietin (Epo) in a regulated fashion, it can be used to investigate the cis- acting regulatory elements of the Epo gene. Comparison of primate and mouse sequences shows strong homology not only in the coding sequence but also within the 5′ flanking region, the first ...
H F Bunn +3 more
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Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability
Genome Biology, 2021 Background The regulation of messenger RNA (mRNA) stability has a profound impact on gene expression dynamics during embryogenesis. For example, in animals, maternally deposited mRNAs are degraded after fertilization to enable new developmental ...
Santiago Gerardo Medina-Muñoz +6 more
semanticscholar +1 more source
Cis-Regulatory Elements in Mammals
International Journal of Molecular Sciences, 2023 In cis-regulatory elements, enhancers and promoters with complex molecular interactions are used to coordinate gene transcription through physical proximity and chemical modifications. These processes subsequently influence the phenotypic characteristics of an organism.
Xingyu Liu +8 more
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Mapping open chromatin by ATAC-seq in bread wheat
Frontiers in Plant Science, 2022 Gene transcription is largely regulated by cis-regulatory elements. Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) is an emerging technology that can accurately map cis-regulatory elements in animals and plants.
Xin Wang +4 more
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