Ultra-long-range interactions between active regulatory elements
bioRxiv, 2022 Contacts between enhancers and promoters are thought to relate to their ability to activate transcription. Investigating mechanisms that drive such chromatin interactions is therefore important for understanding gene regulation.
E. Friman +3 more
semanticscholar +1 more source
Crosstalk between codon optimality and cis-regulatory elements dictates mRNA stability
Genome Biology, 2021 Background The regulation of messenger RNA (mRNA) stability has a profound impact on gene expression dynamics during embryogenesis. For example, in animals, maternally deposited mRNAs are degraded after fertilization to enable new developmental ...
Santiago Gerardo Medina-Muñoz +6 more
semanticscholar +1 more source
Conservation of mRNA and Protein Expression during Development of C. elegans
Cell Reports, 2014 Spatiotemporal control of gene expression is crucial for development and subject to evolutionary changes. Although proteins are the final product of most genes, the developmental proteome of an animal has not yet been comprehensively defined, and the ...
Dominic Grün +5 more
doaj +1 more source
Mapping open chromatin by ATAC-seq in bread wheat
Frontiers in Plant Science, 2022 Gene transcription is largely regulated by cis-regulatory elements. Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) is an emerging technology that can accurately map cis-regulatory elements in animals and plants.
Xin Wang +4 more
doaj +1 more source
Latent regulatory potential of human-specific repetitive elements [PDF]
, 2013 At least half of the human genome is derived from repetitive elements, which are often lineage specific and silenced by a variety of genetic and epigenetic mechanisms. Using a transchromosomic mouse strain that transmits an almost complete single copy of
Barbosa-Morais, Nuno L. +15 more
core +1 more source
Cell fixation and preservation for droplet-based single-cell transcriptomics
BMC Biology, 2017 Background Recent developments in droplet-based microfluidics allow the transcriptional profiling of thousands of individual cells in a quantitative, highly parallel and cost-effective way.
Jonathan Alles +12 more
doaj +1 more source
Tracing tumorigenesis in a solid tumor model at single-cell resolution
Nature Communications, 2020 Understanding tumour development at a granular level is a challenge in solid tumours. Here, the authors provide a cell atlas across tumour development in a genetic model of salivary gland squamous cell carcinoma using single-cell transcriptome and ...
Samantha D. Praktiknjo +9 more
doaj +1 more source
Azole Resistance-Associated Regulatory Motifs within the Promoter of cyp51A in Aspergillus fumigatus
Microbiology Spectrum, 2022 Aspergillus fumigatus is one of the deadliest fungal species, causing hundreds of thousands of deaths each year. Because azoles provide the preferred first-line option for treatment of aspergillosis, the increase in rates of resistance and the poor ...
Alexander Kühbacher +7 more
doaj +1 more source
Systematic discovery of structural elements governing stability of mammalian messenger RNAs. [PDF]
, 2012 Decoding post-transcriptional regulatory programs in RNA is a critical step towards the larger goal of developing predictive dynamical models of cellular behaviour.
Cristea, Ileana M +7 more
core +2 more sources
Post-transcriptional Regulation by 3′ UTRs Can Be Masked by Regulatory Elements in 5′ UTRs
Cell Reports, 2018 Summary: In mRNA sequences, 3′ UTRs are thought to contain most elements that specifically regulate localization, turnover, and translation. Although high-throughput experiments indicate that many RNA-binding proteins (RBPs) also bind 5′ UTRs, much less ...
Kathrin Theil +2 more
doaj +1 more source