Results 61 to 70 of about 5,375,401 (399)

The C-terminus of p63 contains multiple regulatory elements with different functions [PDF]

, 2010
The transcription factor p63 is expressed as at least six different isoforms, of which two have been assigned critical biological roles within ectodermal development and skin stem cell biology on the one hand and supervision of the genetic stability of ...
Candi, Eleonora, Durst, Florian, Dötsch, Volker, Melino, Gennaro, Ou, Horng Der, Rajalingam, Krishnaraj, Schäfer, Birgit, Straub, Wesley E., Weber, Tobias Alexander   +8 more
core   +2 more sources

Role of Genetic Variation in Transcriptional Regulatory Elements in Heart Rhythm

Cells, 2023
Genetic predisposition to cardiac arrhythmias has been a field of intense investigation. Research initially focused on rare hereditary arrhythmias, but over the last two decades, the role of genetic variation (single nucleotide polymorphisms) in heart ...
Timo Jonker, Phil Barnett, Gerard J. J. Boink, Vincent M. Christoffels   +3 more
doaj   +1 more source

Tissue‐specific regulatory elements in mammalian promoters

Molecular Systems Biology, 2007
Transcription factor-binding sites and the cis-regulatory modules they compose are central determinants of gene expression. We previously showed that binding site motifs and modules in proximal promoters can be used to predict a significant portion of mammalian tissue-specific transcription.
Andrew D. Smith, Pavel Sumazin, Michael Q. Zhang   +2 more
openalex   +4 more sources

ENCODE: A Sourcebook of Epigenomes and Chromatin Language [PDF]

Genomics & Informatics, 2013
Until recently, since the Human Genome Project, the general view has been that the majority of the human genome is composed of junk DNA and has little or no selective advantage to the organism.
Maryam Yavartanoo, Jung Kyoon Choi
doaj   +1 more source

Remotely acting SMCHD1 gene regulatory elements: in silico prediction and identification of potential regulatory variants in patients with FSHD [PDF]

, 2015
Background: Facioscapulohumeral dystrophy (FSHD) is commonly associated with contraction of the D4Z4 macro-satellite repeat on chromosome 4q35 (FSHD1) or mutations in the SMCHD1 gene (FSHD2).
B Mifsud, C Huichalaf, C Wijmenga, E Lieberman-Aiden, I Dunham, J Dekker, J Winston, KS Pollard, L Daxinger, LM Hartweck, M Larsen, M Richards, M Upadhyaya, MP Creyghton, N Harmston, R Andersson, RE Thurman, RJ Lemmers, RJ Lemmers, RJ Lemmers, S Bhatia, S Sacconi, SE Hamby, SS Rao, TI Jones, W Zeng, Z Yao   +26 more
core   +2 more sources

Machine-guided design of cell-type-targeting cis-regulatory elements

Nature
Cis-regulatory elements (CREs) control gene expression, orchestrating tissue identity, developmental timing and stimulus responses, which collectively define the thousands of unique cell types in the body1–3.
Sager J. Gosai, Rodrigo I. Castro, Natalia Fuentes, John C. Butts, Kousuke Mouri, M. Alasoadura, S. Kales, T. T. Nguyen, R. Noche, Arya S. Rao, Mary T Joy, P. Sabeti, Steven K. Reilly, Ryan Tewhey   +13 more
semanticscholar   +1 more source

Identifying regulatory elements in eukaryotic genomes [PDF]

Briefings in Functional Genomics and Proteomics, 2009
Proper development and functioning of an organism depends on precise spatial and temporal expression of all its genes. These coordinated expression-patterns are maintained primarily through the process of transcriptional regulation. Transcriptional regulation is mediated by proteins binding to regulatory elements on the DNA in a combinatorial manner ...
Leelavati, Narlikar, Ivan, Ovcharenko
openaire   +2 more sources

Widespread Long-range Cis-Regulatory Elements in the Maize Genome

Nature Plants, 2019
Genetic mapping studies on crops suggest that agronomic traits can be controlled by gene–distal intergenic loci. Despite the biological importance and the potential agronomic utility of these loci, they remain virtually uncharacterized in all crop ...
William A Ricci, Zefu Lu, Lexiang Ji, Alexandre P. Marand, Christina L. Ethridge, N. Murphy, Jaclyn M. Noshay, M. Galli, M. K. Mejía-Guerra, M. Colomé-Tatché, F. Johannes, M. Rowley, V. Corces, J. Zhai, M. Scanlon, E. Buckler, A. Gallavotti, Nathan M. Springer, Robert J. Schmitz, Robert J. Schmitz, Xiaoyu Zhang   +20 more
semanticscholar   +1 more source

Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer

Nature Communications, 2020
Prostate cancer is the second most commonly diagnosed malignancy among men worldwide. Recurrently mutated in primary and metastatic prostate tumors, FOXA1 encodes a pioneer transcription factor involved in disease onset and progression through both ...
Stanley Zhou, James R. Hawley, F. Soares, Giacomo Grillo, Mona Teng, S. A. Madani Tonekaboni, Junjie T Hua, Ken J. Kron, P. Mazrooei, Musaddeque Ahmed, C. Arlidge, Hwa Young Yun, J. Livingstone, Vincent Huang, Takafumi N. Yamaguchi, S. M. G. Espiritu, Yanyun Zhu, T. Severson, Alex Murison, S. Cameron, W. Zwart, T. H. van der Kwast, Trevor J Pugh, M. Fraser, P. Boutros, R. Bristow, H. He, M. Lupien   +27 more
semanticscholar   +1 more source

MicroRNAs as regulatory elements in psoriasis

Open Medicine, 2016
Abstract Psoriasis is a chronic, autoimmune, and complex genetic disorder that affects 23% of the European population. The symptoms of Psoriatic skin are inflammation, raised and scaly lesions. microRNA, which is short, nonprotein-coding, regulatory RNAs, plays critical roles in psoriasis.
Liu Yuan, Liu Quanzhong
openaire   +3 more sources