Results 71 to 80 of about 5,141,166 (402)
Nature Communications, 2019 Modern genetic studies indicate that human brain evolution is driven primarily by changes in gene regulation, which requires understanding the biological function of largely non-coding gene regulatory elements, many of which act in tissue specific manner.
H. Won +4 more
semanticscholar +1 more source
An Exonic Splicing Enhancer within a Bidirectional Coding Sequence Regulates Alternative Splicing of an Antisense mRNA [PDF]
, 2010 The discovery of increasing numbers of genes with overlapping sequences highlights the problem of expression in the context of constraining regulatory elements from more than one gene.
Hastings, Michelle Laura +4 more
core +1 more source
Evidence of widespread degradation of gene control regions in hominid genomes [PDF]
, 2005 Although sequences containing regulatory elements located close to protein-coding genes are often only weakly conserved during evolution, comparisons of rodent genomes have implied that these sequences are subject to some selective constraints ...
Eyre-Walker, Adam +2 more
core +3 more sources
Population Ecology, EarlyView.We investigate the seasonal dynamics of two freshwater snails, Biomphalaria straminea and Melanoides tuberculata, in artificial reservoirs of the Brazilian semiarid region. Despite regulated hydrology, B. straminea exhibited strong seasonal fluctuations associated with dry periods, while M. tuberculata maintained stable populations throughout the year,
Lucas Henrique Sousa da Silva +6 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2016 DNA methylation is an important epigenetic modification involved in many biological processes and diseases. Many studies have mapped DNA methylation changes associated with embryogenesis, cell differentiation, and cancer at a genome-wide scale.
Junchen Gu +11 more
doaj +1 more source
A Systems Biology Approach on the Regulatory Footprint of Human Endogenous Retroviruses (HERVs)
Diseases, 2022 Human endogenous retroviruses (HERVs) are a family of endogenous retroviruses that comprise the ~8.93% of the human genome sequence, with a high proportion being human specific.
Georgios S. Markopoulos
doaj +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Super-Enhancers Dysregulations in Hematological Malignancies
Cells, 2022 Hematological malignancies affecting either the lymphoid or the myeloid lineages involve epigenetic mutations or dysregulation in the majority of cases.
Yannis Belloucif, Camille Lobry
doaj +1 more source
RNA Regulatory Elements and Polyadenylation in Plants [PDF]
Frontiers in Plant Science, 2012 Alternative poly(A) site choice (also known as alternative polyadenylation, or APA) has the potential to affect gene expression in qualitative and quantitative ways. APA may affect as many as 82% of all expressed genes in a plant. The consequences of APA include the generation of transcripts with differing 3'-UTRs (and thus differing regulatory ...
openaire +4 more sources
Cis-regulatory elements and human evolution [PDF]
Current Opinion in Genetics & Development, 2014 AbstractModification of gene regulation has long been considered an important force in human evolution, particularly through changes tocis-regulatory elements (CREs) that function in transcriptional regulation. For decades, however, the study ofcis-regulatory evolution was severely limited by the available data.
Adam Siepel, Leonardo Arbiza
openaire +5 more sources