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REGULATORY T-LYMPHOCYTES IN LYMPHOMAGENESIS
2020B-cell lymphomas are a heterogenous group of tumours that account for 85% of all non-Hodgkin lymphomas (NHL), tumours derived from cells of lymphoid lineage. B-lymphomas originate from various developmental stages of B lymphocytes. Classical Hodgkin’s lymphoma (cHL) also originates from B lymphocytes.
Gršković, Paula +5 more
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Regulatory function of human CD4+ cytolytic T lymphocytes
Transplant Immunology, 1999Allograft rejection is mediated by both CD4+ and CD8+ T cells. The lytic function of the classic CD8+ cytolytic T lymphocytes (CTL) occurs through recognition of allogeneic major histocompatibility complex (MHC) class I on the surface of the graft. CD4+ CTL recognize MHC class II through a direct recognition pathway or an indirect pathway where MHC ...
N J, Poindexter +3 more
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Role of α-fetoprotein in differentiation of regulatory T lymphocytes
Doklady Biological Sciences, 2017The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4+ lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-proliferating activated CD4+ cells.
V A, Chereshnev +6 more
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Mechanisms of Surveillance of Dendritic Cells by Regulatory T Lymphocytes
2015Regulatory T cells (Tregs) are critical to maintain the homeostasis of the organism, i.e., to prevent (excessive) inflammatory reactions against self and nonself. Data in the literature suggest that a variety of suppressive mechanisms exist that may act selectively depending on the tissue environment. An interesting question is whether dendritic cells (
Maxime, Dhainaut, Muriel, Moser
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The Effects of Tacrolimus Ointment on Regulatory T Lymphocytes in Atopic Dermatitis
Journal of Clinical Immunology, 2006Only very recently studies were conducted in order to evaluate the impact of regulatory T (Treg) cells in the pathophysiology of atopic dermatitis (AD). Nine adult patients with moderate-to-severe AD in riacutization period of a chronic disease were given tacrolimus ointment, while seven hydrocortisone butyrate ointment, that served as controls.
Caproni, Marzia +5 more
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Role of Regulatory T Lymphocytes in Health and Disease
2020T cells are conventionally categorized into two basic types, viz., CD4+ helper and CD8+ cytotoxic T cells. CD4+ T cells were known to “help” in the activation and differentiation of various immune cells such as NK cells, macrophages, and dendritic cells, whereas CD8+ T cells were known to kill foreign antigens.
Niti Shokeen +6 more
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Contingent Genetic Regulatory Events in T Lymphocyte Activation
Science, 1989Interaction of antigen in the proper histocompatibility context with the T lymphocyte antigen receptor leads to an orderly series of events resulting in morphologic change, proliferation, and the acquisition of immunologic function. In most T lymphocytes two signals are required to initiate this process, one supplied by the antigen receptor and the ...
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Regulatory factors for initial T lymphocyte lineage specification
Current Opinion in Hematology, 2007Initiation of T lymphocyte development depends on balanced regulatory inputs from multiple essential transcription factors. This review highlights contributions of E2A, hematopoietic transcription factor PU.1, growth factor independence (Gfi)-1, T cell factor (TCF)-1, and Runx factors and their interactions with the Notch pathway to promote T cell ...
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CD4+CD25+ Regulatory T Lymphocytes in Malignant Pleural Effusion
American Journal of Respiratory and Critical Care Medicine, 2005Abstract Background Active suppression by CD4+CD25+ regulatory T lymphocytes plays an important role in the downregulation of T-cell responses to foreign and self-antigens. Objective To analyze whether the CD4+CD25 ...
Yi-Qiang, Chen +7 more
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[Regulatory T lymphocytes CD4(+): current issues].
Medecine sciences : M/S, 2012Regulatory T cells (Treg) are involved in the maintenance of peripheral tolerance and in the prevention of autoimmune diseases. They are also essential to the regulation of immune responses observed in allergy, transplantation, cancers and infectious diseases. Most of Treg, called natural, differentiate in the thymus and are defined by their expression
Aurélie, Siri +2 more
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