Results 11 to 20 of about 2,996,073 (354)
Impact of chronic alcohol exposure on conventional and regulatory murine T cell subsets
Frontiers in Immunology, 2023 IntroductionChronic alcohol use poses significant negative consequences to public health and, among its many biologic effects, is associated with significant T cell dysregulation within the adaptive immune system that has yet to be fully characterized ...
Cameron W. Paterson +7 more
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CD8+ Regulatory T Cell – A Mystery to Be Revealed
Frontiers in Immunology, 2021 Regulatory T cells (Treg) are essential to maintain immune homeostasis and prevent autoimmune disorders. While the function and molecular regulation of Foxp3+CD4+ Tregs are well established, much of CD8+ Treg biology remains to be revealed. Here, we will
Shruti Mishra +3 more
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Nanodrugs Targeting T Cells in Tumor Therapy
Frontiers in Immunology, 2022 In contrast to conventional anti-tumor agents, nano-carriers allow co-delivery of distinct drugs in a cell type-specific manner. So far, many nanodrug-based immunotherapeutic approaches aim to target and kill tumor cells directly or to address antigen ...
Maximilian Haist +2 more
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Regulating regulatory T cells [PDF]
Bone Marrow Transplantation, 2006 Regulatory T cells (Tregs) are a specialized subpopulation of T cells that act to suppress activation of other immune cells and thereby maintain immune system homeostasis, self-tolerance as well as control excessive response to foreign antigens. The mere concept of Tregs was the subject of significant controversy among immunologists for many years ...
N T, Le, N, Chao
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Frontiers in Cell and Developmental Biology, 2022 B cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions.
Diaoyi Tan +17 more
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Regulatory T Cell Metabolism in Atherosclerosis
Metabolites, 2020 Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a ...
Jeroen Baardman, Esther Lutgens
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Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development. [PDF]
PLoS ONE, 2015 T cells reactive to microbiota regulate the pathogenesis of inflammatory bowel disease (IBD). As T cell trafficking to intestines is regulated through interactions between highly specific chemokine-chemokine receptors, efforts have been made to develop ...
Heather L Evans-Marin +9 more
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Frontiers in Immunology, 2018 Regulatory T cells (Tregs) are an attractive therapeutic tool for several different immune pathologies. Therapeutic Treg application often requires prolonged in vitro culture to generate sufficient Treg numbers or to optimize their functionality, e.g ...
Anna Nowak +12 more
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Regulatory T cell function in autoimmune disease
Journal of Translational Autoimmunity, 2021 Autoimmune diseases are characterized by a failure of tolerance to own body components resulting in tissue damage. Regulatory T cells are gatekeepers of tolerance.
Anandi Rajendeeran, Klaus Tenbrock
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Metabolites produced by commensal bacteria promote peripheral regulatory T cell generation
Nature, 2013 Intestinal microbes provide multicellular hosts with nutrients and confer resistance to infection. The delicate balance between pro- and anti-inflammatory mechanisms, essential for gut immune homeostasis, is affected by the composition of the commensal ...
Nicholas Arpaia +10 more
semanticscholar +1 more source