Results 11 to 20 of about 2,009,353 (358)
Journal of Investigative Dermatology, 2006 Immunologic self-tolerance is critically dependent on the induction but also on the downregulation of immune responses. Though ignored and neglected for many years, suppressor T cells, now renamed regulatory T cells (Tregs), play an important role in the negative regulation of immune responses. Several subsets of Tregs have been described.
Agatha Schwarz +2 more
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Potential Application of T-Follicular Regulatory Cell Therapy in Transplantation
Frontiers in Immunology, 2021 Regulatory T cells (Tregs) constitute a small proportion of circulating CD4+ T cells that function to maintain homeostasis and prevent autoimmunity. In light of their powerful immunosuppressive and tolerance-promoting properties, Tregs have become an ...
Caroline Dudreuilh +14 more
doaj +1 more source
Regulatory T cell ablation causes acute T cell lymphopenia. [PDF]
PLoS ONE, 2014 Regulatory T (Treg) cells enforce T cell homeostasis and maintain peripheral T cell tolerance. Here we report a previously unappreciated phenomenon of acute T cell lymphopenia in secondary lymphoid organs and non-lymphoid tissues triggered by Treg cell ...
Bruno Moltedo +2 more
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Plasticity within the αβ+CD4+ T-cell lineage: when, how and what for? [PDF]
Open Biology, 2013 Following thymic output, αβ+CD4+ T cells become activated in the periphery when they encounter peptide–major histocompatibility complex. A combination of cytokine and co-stimulatory signals instructs the differentiation of T cells into various lineages ...
Stephanie M. Coomes +2 more
doaj +1 more source
Impact of chronic alcohol exposure on conventional and regulatory murine T cell subsets
Frontiers in Immunology, 2023 IntroductionChronic alcohol use poses significant negative consequences to public health and, among its many biologic effects, is associated with significant T cell dysregulation within the adaptive immune system that has yet to be fully characterized ...
Cameron W. Paterson +7 more
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Regulatory T Cells as Immunotherapy [PDF]
Frontiers in Immunology, 2014 Regulatory T cells (Tregs) suppress exuberant immune system activation and promote immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the biomedical community has developed an intense interest in using Tregs for immunotherapy.
Franco R. D'Alessio +2 more
openaire +4 more sources
Nanodrugs Targeting T Cells in Tumor Therapy
Frontiers in Immunology, 2022 In contrast to conventional anti-tumor agents, nano-carriers allow co-delivery of distinct drugs in a cell type-specific manner. So far, many nanodrug-based immunotherapeutic approaches aim to target and kill tumor cells directly or to address antigen ...
Maximilian Haist +2 more
doaj +1 more source
Regulatory T Cell Metabolism in Atherosclerosis
Metabolites, 2020 Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a ...
Jeroen Baardman, Esther Lutgens
doaj +1 more source
Regulatory T cells in paracoccidioidomycosis [PDF]
Virulence, 2018 This review addresses the role of regulatory T cells (Tregs), which are essential for maintaining peripheral tolerance and controlling pathogen immunity, in the host response against Paracoccidioides brasiliensis, a primary fungal pathogen. A brief introduction on the general features of Treg cells summarizes their main functions, subpopulations ...
Vera L. G. Calich +2 more
openaire +4 more sources
Unexpected Regulatory Role of CCR9 in Regulatory T Cell Development. [PDF]
PLoS ONE, 2015 T cells reactive to microbiota regulate the pathogenesis of inflammatory bowel disease (IBD). As T cell trafficking to intestines is regulated through interactions between highly specific chemokine-chemokine receptors, efforts have been made to develop ...
Heather L Evans-Marin +9 more
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